Alabama is currently home to 1289 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)
Recruiting
The ProActive registry is a longitudinal, multi-center study with a prospective arm observing clinical care for patients receiving physician ordered Prospera, an allograft rejection test, and a historical control arm collecting data on cases at the same sites whose kidney allograft rejection status was managed with Serum Creatinine SCr/estimated Glomerular Filtration Rate eGFR. This registry will compare patient management and outcomes in patients who receive Prospera (Prospera arm) to the outco... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/08/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Kidney Transplant Rejection
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Recruiting
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
Gender:
All
Ages:
18 years and above
Trial Updated:
06/08/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Septic Shock, Endotoxemia
B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults
Recruiting
This study will examine how various FDA-approved seasonal influenza vaccine types, used in a manner consistent with their approved use, impact the characteristics of influenza specific antibodies in humans, and how these responses differ based on age and prior immunization history.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
06/07/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Influenza
Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis
Recruiting
The purpose of the study is to describe Hemophagocytic lymphohistiocytosis (HLH) in patients with lymphoma to identify possible therapeutic strategies to improve overall survival of the patients with lymphoma associated hemophagocytic lymphohistiocytosis.
Gender:
All
Ages:
All
Trial Updated:
06/01/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Lymphoma, Hemophagocytic Lymphohistiocytoses
The Impact of Insomnia on Pain in HIV
Recruiting
The overall objective of this application is to investigate the impact of insomnia on pain, physical functioning, and inflammation in people living with HIV. The two aims of this study to determine 1) whether insomnia promotes increased sensitivity and inflammatory reactivity to pain stimuli, and 2) if weekly fluctuations in insomnia burden drive changes in inflammation, pain severity, and physical functioning in people living with HIV. This research could help confirm insomnia as a therapeutic... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/01/2023
Locations: UAB, Birmingham, Alabama
Conditions: HIV, Insomnia
Oxalate-Driven Host Responses in Kidney Stone Disease
Recruiting
This study is looking to understand the role of oxalate on kidney stone development and immunity. This study will enroll healthy participants and participants with calcium oxalate kidney stones (CaOx KS). Participants will be in this study for about 3 weeks, consume controlled diets, and provide blood and urine specimens.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/31/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Kidney Stones
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
Recruiting
People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) the relationship between healthcare providers' attitudes towards working with PLWH who use drugs and providers' acceptance and practice of structural and relational harm reduction; (b) the degree to which... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/31/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Human Immunodeficiency Virus, Substance Use, Stigma, Social
MYLUNG Consortium Part 3: Observational Study
Recruiting
This longitudinal study looks to quantify the testing timeline, operational barriers, and outcomes of biomarker-guided therapy in a large, community-based, and largely unselected patient population with early stage and advanced stage, treatment-naive non-small cell lung cancer, whether squamous or non-squamous.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: Southern Cancer Center, PC, Daphne, Alabama
Conditions: Carcinoma, Non-Small-Cell Lung
Ketone Ester and Acute Salt (KEAS) in Young Adults
Recruiting
Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs the ability of systemic blood vessels and the kidneys to control blood pressure, which contributes to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. There is a critical need for strategies to counteract the effects of... Read More
Gender:
All
Ages:
Between 18 years and 39 years
Trial Updated:
05/30/2023
Locations: Auburn University, Auburn, Alabama
Conditions: Salt; Excess, Hypertension
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents
Recruiting
This will be a 6-month randomized clinical trial with two arms: moderately carbohydrate-restricted diet and a fat-restricted control diet. This 6-month study will have 2 phases: a 12-week controlled feeding phase and a 12-week "free living" phase. During the controlled feeding phase, all food will be provided to the families of the participants for the entirety of the 12 weeks. Participants (n=80) will have been diagnosed with NAFLD based on the presence of current evidence of active disease, wh... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
05/26/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Non-Alcoholic Fatty Liver Disease, Obesity
Renal Metabolism of Glycolate to Oxalate
Recruiting
This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/26/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Healthy
International CIPN Assessment and Validation Study
Recruiting
This is an observational study of chemotherapy-induced peripheral neurotoxicity (CIPN) patients to be investigated prospectively in order to assess responsiveness of a set of outcome measures in an international multi-center study.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Birmingham School of Nursing, University of Alabama, Birmingham, Alabama
Conditions: Chemotherapy-induced Peripheral Neuropathy, Quality of Life