California is currently home to 5958 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Radicle GI Health 24: A Study of Health and Wellness Products on GI Health and Related Health Outcomes
Recruiting
A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on GI health and related health outcomes
Gender:
All
Ages:
Between 21 years and 105 years
Trial Updated:
04/18/2024
Locations: Radicle Science, Inc, Del Mar, California
Conditions: Abdominal Pain, GI Disorders, Digestion
Effects of Using a Storybook, to Explain Leukemia to Children Versus the Standard Child Life Intervention, on Parental Stress.
Recruiting
The goal of this clinical trial is to measure the effects of using a storybook versus standard child life intervention with parents of children newly diagnosed with leukemia on parental stress. The main questions it aims to answer are: What effect will the storybook have on parent/legal guardian stress at three timepoints: baseline, discharge, and follow up? Will this storybook impact parent/legal guardian comfort levels and improve their child's understanding? Participants will be asked to c... Read More
Gender:
All
Ages:
3 years and above
Trial Updated:
04/18/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Leukemia
A Study to Evaluate Safety and Efficacy of a New Formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution in Patients With Dry Eye Disease
Recruiting
The purpose of this study is to evaluate the safety and efficacy of two different concentrations of the new formulation of rhNGF ophthalmic solution versus vehicle, in order to demonstrate superiority of at least one of the two concentrations over vehicle in the improvement of ocular symptoms of dry eye in participants with dry eye disease (DED). The rhNGF ophthalmic solution, or vehicle, will be administered as one drop in each eye, three times a day, for 4 weeks. Participants will attend a tot... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: East West Eye Institute, Torrance, California
Conditions: Dry Eye Disease
A Study to Evaluate the Efficacy, and Safety Study of Ruxolitinib Cream in Adults With Moderate Atopic Dermatitis
Recruiting
This study is being conducted to establish the efficacy of ruxolitinib cream in participants with moderate AD who had an inadequate response to, or are intolerant to, or contraindicated to topical corticosteroid (TCS)s and topical calcineurin inhibitor (TCI)s.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: First Oc Dermatology, Fountain Valley, California
Conditions: Atopic Dermatitis
A Study to Evaluate the Safety and Tolerability of Maximal Use Ruxolitinib Cream
Recruiting
This study is being conducted to determine the safety and tolerability of ruxolitinib 1.5% cream under maximal use conditions in participants with Prurigo Nodularis (PN).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/18/2024
Locations: First Oc Dermatology, Fountain Valley, California
Conditions: Prurigo Nodularis
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Recruiting
The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 [NCT05620823] or INCB 54707-302 [NCT05620836]).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Investigative Site US315, Laguna Niguel, California
Conditions: Hidradenitis Suppurativa (HS)
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Recruiting
This study is conducted to determine the safety and tolerability of INCB161734 as a single agent or in combination with other anticancer therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: UCLA Healthcare Hematology-Oncology, Santa Monica, California
Conditions: Solid Tumors
A Clinical Study of the V116 Vaccine for Children and Teenagers (V116-013)
Recruiting
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of V116 compared to PPSV23 in children 2 through 17 years of age. Researchers want to learn if V116 is as good as, or is better than the PPSV23 vaccine in terms of the antibody immune response. V116 and PPSV23 will be studied in children and teenagers who have a higher risk of getting invasive pneumococcal disease (IPD).
Gender:
All
Ages:
Between 2 years and 17 years
Trial Updated:
04/18/2024
Locations: Madera Family Medical Group ( Site 0120), Madera, California
Conditions: Pneumococcal Infection
Efficacy And Safety Of MK-6194 In Adult Participants With Systemic Lupus Erythematosus (MK-6194-006)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of MK-6194 in adult participants with Systemic Lupus Erythematosus. The primary hypothesis is that at least 1 of the MK-6194 arms is superior to placebo in the primary endpoint of percentage of participants with systemic lupus erythematosus responder index (SRI-4) response at Week 28.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/18/2024
Locations: Arthritis & Osteoporosis Medical Center - La Palma ( Site 0108), La Palma, California
Conditions: Systemic Lupus Erythematosus
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
Recruiting
This is a first-in-human, Phase 1, non-randomized, multicenter, open-label clinical study designed to investigate the safety, tolerability, dosimetry, biodistribution, and pharmacokinetics (PK) of [225Ac]-FPI-2068, [111In]-FPI-2107, and FPI-2053 in metastatic and/or recurrent solid tumors (HNSCC, NSCLC, mCRC, PDAC).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Hoag Hospital, Irvine, California
Conditions: Advanced Solid Tumor, Metastatic Colorectal Carcinoma, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma
A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Recruiting
The main purpose of this study is to assess the safety and tolerability of a single dose of LY3938577 in healthy participants and participants with Type 2 Diabetes Mellitus (T2DM) (Part A) and multiple doses of LY3938577 in participants with T2DM (Part B). The study will last approximately 6 weeks for Part A and approximately 10 weeks for Part B respectively.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/18/2024
Locations: CenExel ACT, Anaheim, California
Conditions: Healthy, Type 2 Diabetes Mellitus
A Study of LY3872386 in Healthy Participants and Participants With Atopic Dermatitis
Recruiting
The main purpose of this study is to evaluate the safety and tolerability of LY3872386 in healthy participants and participants with atopic dermatitis. The safety of prednisone is also evaluated in healthy participants. Blood tests will be performed to investigate how the body processes the LY3872386 following single and multiple dosing in healthy participants and participants with atopic dermatitis. Blood tests will also be performed to investigate how the body processes the prednisone in healt... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/18/2024
Locations: CenExel ACT, Anaheim, California
Conditions: Healthy, Atopic Dermatitis