Tennessee Clinical Trials

A listing of Tennessee clinical trials actively recruiting patient volunteers.

Tennessee is a lively and lovely state known as the birthplace of bluegrass and the site of Graceland and Dollywood. It's also the place to go to see one of America's most iconic national parks, The Great Smoky Mountain National Park. Nashville is where you can immerse yourself in the history of the music business, while Memphis, Knoxville, and Gatlinburg each offer their own perks and sights. In any of these cities and beyond, sound healthcare is easy to find. Vanderbilt University Medical Center has been ranked #1 in the state, with more than 1,000 acute care beds in service.

Search by Name
Search
Filter by Condition
2204 trials found

Safety and Tolerability Study of Adhansia XR® Extended-Release Capsules in Children

NCT04987762

The purpose of this study is to assess the long-term safety of Adhansia XR in children and to characterize the pharmacokinetics (PK) in 4 to 5 year-olds.

Conditions: Attention Deficit/Hyperactivity Disorder

A Study of ART4215 for the Treatment of Advanced or Metastatic Solid Tumors

NCT04991480

This clinical trial is evaluating a drug called ART4215 in participants with advanced or metastatic solid tumors. The main goals of this study are to: Find the recommended dose of ART4215 that can be given safely to participants alone and in combination with talazoparib Learn more about the side effects of ART4215 alone and in combination with talazoparib Learn more about the effectiveness of ART4215 alone and in combination with talazoparib

Conditions: Advanced Cancer, Metastatic Cancer, Breast Cancer
Phase: Phase 1/2

Study of MTB-9655, an Inhibitor of ACSS2, in Patients With Advanced Solid Tumors

NCT04990739

MetaboMed is developing MTB-9655, an orally bioavailable, first-in-class small molecule inhibitor of the human Acetyl coenzyme A (Acyl-CoA) synthetase short chain family member 2 (ACSS2) enzyme, as a potential treatment for patients with cancer. This study is a Phase 1,First-in-Human (FIH), open-label dose-escalation study of MTB-9655 given daily as a single oral (PO) agent. Up to 30 patients with locally advanced, unresectable and/or metastatic solid tumor(s) are expected to be enrolled in the ...

Conditions: Advanced Solid Tumor

Stroke Thrombectomy and Aneurysm Registry

NCT04994756

This international multi-center registry will be used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information will be used to help predict outcomes that undergo operation for treatment of the above list ...

Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain

A Study to Learn How Safe the Study Drug BAY 2416964 (AhR Inhibitor) in Combination With the Treatment Pembrolizumab is, How This Combination Affects the Body, the Maximum Amount That Can be Given, How it Moves Into, Through and Out of the Body and Its Action Against Advanced Solid Cancers in Adults

NCT04999202

Researchers are looking for a better way to treat advanced solid cancers including head and neck cancer, lung cancer and bladder cancer. In some people with cancer a protein called Aryl Hydrocarbon Receptor (AhR) can prevent immune cells from fighting tumor cells. The study drug, BAY 2416964, is a small molecule which blocks the AhR allowing the body to use its immune response against the cancer cells. Researchers think that BAY 2416964 given together with a cancer treatment called pembrolizuma ...

Conditions: Advanced Solid Tumors

Gut Microbiota in Metabolic Surgery

NCT05000996

Metabolic surgery is an emerging option to treat obesity-related metabolic diseases (e.g., type 2 diabetes) and prevent cardiovascular disease (CVD). Metabolic surgery can profoundly alter the gut microbiota; meanwhile, gut microbiota may affect surgical outcomes. Longitudinal studies that examined pre- to post-surgery changes in gut microbiota and its relation to cardiometabolic health after surgery are limited. Furthermore, few studies have included African Americans, a population with high ra ...

Conditions: Bariatric Surgery Candidate, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidemias, Hypertension, Morbid Obesity

Trial on the Safety and Efficacy of MLS-101 in Patients With Uncontrolled Hypertension

NCT05001945

A randomized, double-blind, placebo-controlled, dose-ranging, Phase II study to evaluate the safety, efficacy, and tolerability of MLS-101 in Subjects With Uncontrolled Hypertension

Conditions: Hypertension, Renal

Clinical Performance of Two Commercial, Daily Disposable Contact Lenses

NCT05010512

The purpose of this study is to compare the clinical performance of DAILIES TOTAL1 ( DT1) contact lenses with Infuse contact lenses.

Conditions: Refractive Errors
Phase: Not Applicable

Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)

NCT05016882

This study is being done to see if a combination of 2 medicines (called NNC0194-0499 and semaglutide) can reduce liver damage in patients with non alcoholic steatohepatitis (NASH). NNC0194-0499 is a new medicine which works in the liver. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. It also helps with weight loss and may reduce liver damage, and so prevent future liver complications. It works in a different way to NNC0194 0499 ...

Conditions: Non-alcoholic Steatohepatitis

A Retrospective Study of Subjects With Thymidine Kinase 2 Deficiency

NCT05017818

This is a descriptive, retrospective, chart-review study where the study's primary goal is to use the vital statics data and other related information to support a comprehensive assessment of survival for all Thymidine Kinase 2 deficiency (TK2d) subjects who have been treated with pyrimidine nucleos(t)ides (chemical-grade dCMP/dTMP, deoxycytidine/deoxythymidine (dC/dT), and/or MT1621), worldwide, compared to an untreated control group by combining this study's data with the treated and untreated ...

Conditions: Thymidine Kinase 2 Deficiency

ESP Block vs Control for Pain Control Following Percutaneous Nephrolithotomy

NCT05024344

The purpose of this study is to investigate the use of the erector spinae (ESP) block in reducing the morphine milligram equivalent (MME) consumption post percutaneous nephrolithotomy. Objectives: - Determine if there is a significant effect on post percutaneous nephrolithotomy MME consumption with the usage of an ESP block vs. saline control. - Determine if there is a significant effect on reported pain levels with the use of an ESP block vs. saline control in post percutaneous nephrolithotomi ...

Conditions: Nephrolithotomy, Percutaneous
Phase: Not Applicable

A Donanemab (LY3002813) Prevention Study in Participants With Alzheimer's Disease (TRAILBLAZER-ALZ 3)

NCT05026866

The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD).

Conditions: Alzheimer Disease