All Clinical Trials

A listing of all clinical trials actively recruiting patient volunteers.

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73194 trials found

Effectiveness of WhatsApp Education and Support Messages for Urolithiasis Prevention

NCT05627622

Kidney and ureteral stones are a common problem in primary care practice with increasing prevalence over the last few decades. Prevention of recurrent stones (which are usually composed primarily of calcium oxalate) is aimed at decreasing the concentrations of the lithogenic factors. There are several metabolic and dietary treatable components. In all patients with urolithiasis, adequate fluid intake and lower body mass index are key components to reducing the risk of recurrent stones. For most ...

Conditions: Urinary Tract Stone
Phase: Not Applicable

Sunlight-mediated Inter-organ Leukocyte Exchange

NCT05627609

Ultraviolet B (UVB) irradiation induces regulatory immune cell types that may transmigrate from the skin to the blood and to the central nervous system and exert regulatory effects. Vitamin D deficiency-associated gene variants should reduce this effect if this is mediated by vitamin D. For this study, participants will be irradiated with UVB for 4 weeks. Single cell RNA Sequencing will be performed on isolated immune cells from skin, blood and Cerebrospinal fluid (CSF), before and after irradia ...

Conditions: Multiple Sclerosis
Phase: Not Applicable

Nutritional Rehabilitation and Markers of Severity in Anorexia Nervosa

NCT05627583

The design of this project is a longitudinal trial in patients with Anorexia Nervosa (AN) during in-hospital rehabilitation. Τhe structure of the study, the questionnaires and data protection policy prepared exclusively for our study, have been reviewed and standardised at Institutional Review Boards (Ethics Committees, IRBs,) in Harokopio University of Athens (HUA), Eginition Hospital (EH), Attiko Hospital (AH) and Sismanoglio Hospital (SG). AN is a psychiatric disorder followed by a psychopat ...

Conditions: Anorexia Nervosa

Meaning Making While Your Child is in Intensive Care

NCT05627531

A quarter of a million children and teenagers are hospitalized annually in Pediatric Intensive Care Units (PICUs) in North America. Having a child hospitalized in a PICU is stressful and affects the mood and coping of their parents. The investigators' prior work has shown how narrative medicine may help. Narrative medicine includes at least one session reading and then having a guided discussion of a poem or short story. The readings are individually selected by the Narrative Medicine Coordinato ...

Conditions: Narrative Medicine
Phase: Not Applicable

Relative Bioavailability of Linaprazan for the Test Formulation vs. Reference Formulation

NCT05627518

This is a single-center, open-label, randomized, single dose, 3-way crossover study in healthy volunteers designed to evaluate the relative bioavailability of a new oral tablet formulation of linaprazan glurate in comparison to a previously studied oral tablet formulation under fasting conditions, and to assess the effect of a high fat, high calorie meal on the pharmacokinetics (PK) of linaprazan glurate and the active substance linaprazan after the administration of the new oral tablet formulat ...

Conditions: Safety, Bioavailability, Pharmacokinetics

Pragmatic Patient-oriented 12-Month Extension Study of Dialectical Behavior Therapy Booster Sessions for Youth With Bipolar Disorder

NCT05627492

The study intervention is DBT adapted for youth with bipolar disorder. Participants will have completed one full year of DBT in a previous study. This study is examining use of booster sessions. It is delivered in the form of individual sessions and skills sessions, based on the preference of the study participant. The study participant may also receive skills coaching via phone. There is no standard reference therapy/comparator against which the study intervention is being compared.

Conditions: Bipolar Disorder
Phase: Not Applicable

Multi-cohort Study of Surufatinib Plus Sintilimab in Metastatic NEN and Pancreatic Carcinoma Who Failed Standard Chemotherapy

NCT05627427

Neuroendocrine neoplams (NENs) are uncommon, but with a significant increasing incidence and prevalence with advances in diagnostic techniques. NENs can originate from various parts of the body and are highly heterogeneous. Neuroendocrine tumors (NET), dividing into G1, G2, G3, are well-differentiated types with slow growth and neuroendocrine carcinoma (NEC) are poorly-differentiated with high malignancy. Pancreatic carcinoma is one of the malignant neoplasms with a very high mortality rate. Fo ...

Conditions: Neuroendocrine Tumor Grade 3, Neuroendocrine Carcinoma, Pancreatic Carcinoma

Customized Multiple Orbital Wall Decompression for Sight-threatening Graves's Ophthalmopathy

NCT05627401

Graves' orbitopathy (GO) is an disfiguring and disabling autoimmune condition. Sight-threatening GO is an most severe form and occurs in about 5% of patients with Graves' disease. It can cause blurred vision, color vision and vision function damage, and affects the quality of life. The goal of this retrospective cohort study is to propose a customized orbital decompression algorithm for patients with sight-threatening Graves'ophthalmopathy and to explore the therapeutic effect of customized orbi ...

Conditions: Thyroid Eye Disease

Development and Validation of a Deep Learning System for Nasopharyngeal Carcinoma Using Endoscopic Images

NCT05627310

Develop a deep learning algorithm via nasal endoscopic images from eight NPC treatment centerto detect and screen nasopharyngeal carcinoma(NPC).

Conditions: Nasopharyngeal Carcinoma

Applying Artificial Intelligence to Optimize Early-stage Hepatocellular Carcinoma Treatment Based on Multi-modal Image

NCT05627297

This study intends to establish two prognostic models based on contrast-enhanced ultrasound (CEUS) and dynamic enhanced magnetic resonance (DE-MRI) multimodal images: prognostic model of liver cancer patients after hepatectomy and prognostic model of liver cancer patients after radiofrequency ablation. Combined with artificial intelligence imaging omics, traditional imaging omics and clinical information, to predict and compare the prognosis of two different treatment methods for early liver can ...

Conditions: Hepatocellular Carcinoma

A Prospective Clinical Trial of Colostomy-replacement Combined With Bio-mesh Placement in the Prevention of SSIH

NCT05627284

The goal of this clinical trial is to explore the safety and effectiveness of stoma reversal combining bio-mesh placement in patients with high risk of stoma site incisional hernia (SSIH). The main questions it aims to answer are: Whether bio-mesh placement is safe for patients with a high risk of SSIH. Whether stoma reversal combining bio-mesh placement is a preventive strategy for patients with high risk of SSIH. Whether stoma reversal combining bio-mesh placement will trigger other complicat ...

Conditions: Stoma Site Incisional Hernia
Phase: Not Applicable

A Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRCHIVMAB0115-00-AB (VRC01.23LS), Administered Intravenously or Subcutaneously to Healthy Adults

NCT05627258

Background: HIV causes AIDS, a serious disease that can lead to fatal infections. HIV infection can be controlled but not cured, nor is there a vaccine to prevent it. Antibodies may offer a promising new way to prevent HIV infection. Antibodies are proteins that are naturally made by the body to fight germs. One antibody (VRC01.23LS) has been tested in the lab and was found to block HIV-like viruses. Researchers want to find out if it is safe to inject VRC01.23LS into people. Objective: To te ...

Conditions: HIV