The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART)
Recruiting
End-stage heart failure (HF) is a progressive illness with a mortality rate similar to most advanced cancers.Roughly 5% of patients with HF have end-stage disease that is refractory to medical therapy (stage D heart failure). When patients reach this point in their disease, the only treatments known to prolong life are cardiac transplantation or left ventricular assist devices. In patients who do not qualify for these options, or elect a palliative approach, inotropes are frequently used to impr... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
02/19/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Failure
Impact of Early ADL Participation on Outcomes Post DRF
Recruiting
This study is a randomized controlled trial (RCT). This RCT which will study the effect of performing daily activities early after a distal radius fracture being treated conservatively in a cast. This study will have two groups. The experimental group will watch a video and be given a handout on how to perform daily activities with the hand of the injured wrist while in a cast and cast care. The control group will watch a video on cast care and be given a handout on cast care. Outcome measures w... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2024
Locations: Medical Facilities Associates, Washington, Virginia
Conditions: Distal Radius Fracture
Comparison of Bronchodilator Response From Three Different Aerosol Delivery Methods in Patients With COPD Using Hyperpolarized Xe 129 MRI Ventilation Imaging
Recruiting
The goal of this clinical trial is to compare responses to bronchodilator treatment delivered by three different aerosol delivery methods in patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is whether there are differences in lung ventilation following treatment with each of the three methods as measured using hyperpolarized Xe 129 with MRI. Participants will: Receive a standard dose of albuterol delivered using each of 3 aerosol delivery devices.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: University of Virginia Sheridan Snyder Translational Fontaine Research Unit, Charlottesville, Virginia
Conditions: Chronic Obstructive Pulmonary Disease
Chronobiology of Meal Timing: Effects on Vascular and Renal Function
Recruiting
The purpose of this study us to investigate the effects of mistimed eating on blood pressure, kidney function and vascular function.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
02/14/2024
Locations: Virginia Commonwealth Univesity, Richmond, Virginia
Conditions: Hypertension
Antiretroviral Improvement Among Medicaid Enrollees
Recruiting
This study will evaluate whether a new program will affect how often human immunodeficiency virus (HIV) antiretroviral therapy (ART) prescriptions are filled and whether the program improves the health of people living with HIV.
Gender:
All
Ages:
Between 19 years and 64 years
Trial Updated:
02/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Human Immunodeficiency Virus
Using Grassroots Wellness Coaching to Enhance Reach and Sustainability of Behavioral Weight Management
Recruiting
African American adults that live in economically disadvantaged areas are at an increased risk for obesity and cardiometabolic disease. The treatment program being tested in this research study aims to address these factors and increase outcomes for the study population. The purpose of this research study is to find out about the feasibility and acceptability of using house chats (HC) as a model for a weight loss program in a real-world, community-based setting.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Obesity
WE Project: 2.0 Grassroots Wellness Coaching (Phase 2)
Recruiting
African American adults that live in economically disadvantaged areas are at an increased risk for obesity and cardiometabolic disease. The treatment program being tested in this research study aims to address these factors and increase outcomes for the study population. The purpose of this research study is to find out about the feasibility and acceptability of using house chats (HC) as a model for a weight loss program in a real-world, community-based setting.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Obesity
Trial Readiness and Endpoint Assessment in Congenital Myotonic Dystrophy
Recruiting
Congenital Myotonic Dystrophy (CDM) is a multi-systemic, dominantly inherited disorder caused by a trinucleotide repeat expansion (CTGn) in the DMPK gene. CDM occurs when the CTGn increases between the adult myotonic dystrophy type-1 (DM1) parent and the child. Children with CDM present at birth with respiratory insufficiency, talipes equinovarus, feeding difficulties and hypotonia. There is a 30% mortality rate in the first year of life. As children grow, they are at risk for intellectual impai... Read More
Gender:
All
Ages:
Between 0 years and 15 years
Trial Updated:
02/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia +2 locations
Conditions: Congenital Myotonic Dystrophy
A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors
Recruiting
This phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and efficacy of CUSP06 in patients with platinum-refractory/resistant ovarian cancer and other advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: NEXT Oncology, Fairfax, Virginia
Conditions: Ovarian Cancer, Solid Tumor
Hemodynamic Monitoring to Prevent Adverse Events foLlowing cardiOgenic Shock Trial
Recruiting
Pilot Prospective Randomized Unblinded Pragmatic Trial of Pulmonary Artery Hemodynamic Monitoring Following Hospitalization for Cardiogenic Shock
Gender:
All
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Inova Fairfax Medical Campus, Falls Church, Virginia
Conditions: Cardiogenic Shock, Heart Failure, Ambulatory Hemodynamic Monitoring
Parent Involvement in Adolescent Obesity Treatment
Recruiting
A randomized control trial to compare the efficacy of two distinct parent treatments on weight loss maintenance for adolescents with obesity participating in a lifestyle intervention including nutrition education, exercise and behavioral support. Funding support from NIH via 1R01HD095910
Gender:
All
Ages:
Between 12 years and 16 years
Trial Updated:
02/08/2024
Locations: Children's Hospital of Richmond at VCU Healthy Lifestyles Center, Henrico, Virginia
Conditions: Pediatric Obesity
CALM: Managing Distress in Malignant Brain Cancer
Recruiting
The purpose of this study is to test an empirically supported psychotherapeutic intervention, Managing Cancer and Living Meaningfully (CALM), compared to treatment as usual (TAU) in those with malignant brain cancer diagnoses.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Brain Tumor, Brain Metastases, Brain Cancer, Metastatic Lung Cancer, Metastatic Breast Cancer, Metastatic Melanoma, Metastatic Colon Cancer, Metastatic Kidney Cancer