The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer
Recruiting
The purpose of this research is to see if combining gemcitabine, cisplatin and Durvalumab chemotherapy treatments with a direct tumor therapy called Yittrium-90, will work better together to shrink the tumor and control cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: Keary Janet, Fairfax, Virginia
Conditions: Intrahepatic Cholangiocarcinoma
A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
Recruiting
The purpose of this study is to estimate and compare the incidence of overall malignancy, serious infection, and opportunistic infections between new users of ustekinumab and new users of other biologic therapies among adult participants with Crohn's disease (CD) or ulcerative colitis (UC).
Gender:
All
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: NMCP, Portsmouth, Virginia
Conditions: Crohn Disease, Colitis, Ulcerative
Young Adult Eating Habits
Recruiting
Most individuals with obesity become so before age 35 and adolescent's unhealthy dietary patterns, specifically high intake of ultra-processed foods and poor overall diet quality, may contribute to energy overconsumption and weight gain. The overall objective of this research is to establish proof-of-concept for altered reward processing measured by brain response to ultra-processed foods, an increase in ad libitum energy intake, and adverse effects on executive function in response to an ultra-... Read More
Gender:
All
Ages:
Between 18 years and 25 years
Trial Updated:
06/18/2024
Locations: Virginia Polytechnic Institute and State University, Blacksburg, Virginia +1 locations
Conditions: Eating Behavior, Eating Habit
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
Recruiting
Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham. Infants will be followed for three years to examine health outcomes including microbiome development, immune development, metabolic outcomes, and any adverse events.
Gender:
All
Ages:
Between 0 days and 50 years
Trial Updated:
06/17/2024
Locations: Inova Health System, Falls Church, Virginia
Conditions: Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome, Microbiota, Host Microbial Interactions, Gastrointestinal Microbiome
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
Recruiting
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability among African American menthol smokers.
Gender:
All
Ages:
21 years and above
Trial Updated:
06/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Electronic Nicotine Delivery System Flavors
Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)
Recruiting
Posttraumatic Stress Disorder (PTSD) and Substance Use Disorder (SUD) are highly comorbid, and comorbidity increases risk for poor functional outcomes. Risks for poor quality of life and suicide increase further for those with co-occurring PTSD and SUD diagnoses as compared to either condition alone, with suicide attempt rates three times higher for Veterans with alcohol use disorder and PTSD (Norman, Haller, Hamblen, Southwick & Pietrzak, 2018). For patients with PTSD-SUD, there is evidence of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: Salem VA Medical Center, Salem, VA, Salem, Virginia
Conditions: PTSD, Substance Use Disorders
Microbiome Modulation With Prebiotics in PTSD and Cirrhosis
Recruiting
Despite medical advancements, PTSD remains a major issue in Veterans1. Current treatment strategies have relatively poor adherence. In patients with PTSD and cirrhosis, there is greater cognitive impairment as well as changes in gut microbiome structure and function2,3. In addition, when there is concomitant cirrhosis, medication-related treatment options become even narrower from a safety and tolerability perspective and cognitive issues pertaining to cirrhosis could impact participation3. Chan... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, Virginia
Conditions: Cirrhosis, PTSD
eTMS for Veterans and First Responders With PTSD
Recruiting
A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
06/13/2024
Locations: Fralin Biomedical Research Institute, Roanoke, Virginia
Conditions: Post Traumatic Stress Disorder
Effects of Foot Rehabilitation And Minimalist Shoes on Pain, Strength, and Function in Adults With Plantar Fasciopathy
Recruiting
The goal of this clinical trial is to compare the effects of 8 weeks of foot rehabilitation exercises in conjunction with wearing minimalist shoes in individuals with plantar fasciopathy, compared to only performing foot rehabilitation exercises. The main questions it aims to answer are: Will individuals with plantar fasciopathy be able to reduce their pain and improve their self-reported function by performing rehabilitation exercises and wearing minimalist shoes, compared to those only perfor... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
06/12/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Plantar Fascitis, Plantar Fasciopathy, Plantar Fasciitis of Both Feet, Plantar Fasciitis of Right Foot, Plantar Fasciitis of Left Foot, Plantar Fasciitis, Chronic
Self-Management Program for AIS D SCI
Recruiting
About 25-51% of adults with acquired spinal cord injury (SCI) have "AIS D" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and employment. However, counterintuitively, they are also at higher risk of poor subjective well-being (SWB) and related psychosocial outcomes. Preliminary evidence suggests that poorer SWB in this group is associated with distinctive, modifiable factors such as less intensity of... Read More
Gender:
All
Ages:
All
Trial Updated:
06/12/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond, Virginia
Conditions: Psychological Well-Being, Spinal Cord Injuries
PENG vs FICB for Hip Fracture in ED Patients
Recruiting
Regional anesthesia for hip fractures has been shown to decrease rates of delirium in elderly patients with hip fractures as well as improve pain compared to systemic opioids. The Pericapsular Nerve Group (PENG) block has recently received attention as an alternative approach to femoral nerve block and Fascia Iliaca Compartment Block (FICB). The investigators seek to evaluate if there is a difference between the PENG and FICB in terms of efficacy of pain control in ED patients presenting with hi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/12/2024
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Femoral Neck Fractures, Intertrochanteric Fractures
A Clinical Trial Comparing FS With ZOE and Non-eugenol Based Materials in Primary Teeth Pulpotomies
Recruiting
Internal resorption in the most common cause of failure in FS pulpotomies in primary molars. This has been attributed to the release of free eugenol from the zinc and eugenol mixture of the base material over the pulp tissue. Zinc oxide-eugenol (ZOE) paste is the most common base material placed over the infected pulp tissues during pulpotomies of primary molars, however the evidence suggests that the eugenol component has been associated with the failure of the vital pulp treatment in primary m... Read More
Gender:
All
Ages:
Between 3 years and 7 years
Trial Updated:
06/10/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Pulpitis