Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.
Recruiting
In an effort to elucidate whether the Harmonic Scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the Harmonic Scalpel will be compared to a control group which uses electrocautery. This study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.
Gender:
All
Ages:
Between 20 years and 75 years
Trial Updated:
11/20/2023
Locations: Sentara Norfolk General Hospital/Sentara Heart Hospital, Norfolk, Virginia
Conditions: Lung Cancer
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
Recruiting
The overall goal of this project is to collect initial human data on the effects of novel compounds on safety (interactions with an opioid drug, e.g., buprenorphine) and early efficacy signals (subjective effects on negative affect, craving, and opioid withdrawal) in OUD subjects currently in MOUD treatment with buprenorphine.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/20/2023
Locations: CARI Research Clinic- VCU Institute for Drug and Alcohol Studies, Richmond, Virginia
Conditions: Addiction, Opioid Use, Substance Use Disorders, Opioid Use Disorder
Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Panel
Recruiting
The study is designed as a prospective, multicentric, clinical study to investigate the positive percent agreement (PPA) and negative percent agreement (NPA) of the Panbio™ COVID-19/Flu A&B Panel using anterior nasal swab specimens tested directly, relative to the comparator methods, Roche cobas® SARS-CoV-2 (K231306) and Quidel Lyra® Influenza A+B Assay(K230236) (RT-PCR) in symptomatic patients suspected of respiratory viral infection by a healthcare provider.
Gender:
All
Ages:
2 years and above
Trial Updated:
11/17/2023
Locations: Advanced Pediatrics, Vienna, Virginia
Conditions: COVID-19, Influenza A, Influenza B
A Pilot Study to Examine the Impact of a Therapy Dog Intervention on Loneliness and Related Health Outcomes in Vulnerable Populations
Recruiting
The purpose of this research study is to test whether an animal-assisted interaction (AAI) intervention is better than conversation with another person or treatment as usual for improving mood, anxiety, loneliness, quality of life, and indicators of health care services such as number of hospitalizations, length of hospital stay, and cost of services. Participants will be patients admitted for an inpatient stay at Virginia Commonwealth University Health who meet the study entry requirements.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Loneliness, Depression, Anxiety, Quality of Life
Head and Intraocular Trauma Tool for the Identification of Mild Traumatic Brain Injury
Recruiting
Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or "HITT"), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the R... Read More
Gender:
All
Ages:
Between 13 years and 45 years
Trial Updated:
11/16/2023
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Brain Injuries, Traumatic
Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
Recruiting
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuropathic Pain
Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer
Recruiting
To determine the recommended phase 2 dose (RP2D) of niraparib and neratinib in combination in patients with advanced solid tumors during Phase 1. To evaluate clinical benefit (≥4-month progression-free survival [PFS]) of niraparib and neratinib in patients with platinum-resistant ovarian cancer in Phase 1b.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Advanced Solid Tumor, Ovarian Cancer
PrEP Intervention Among Black Sexual Minority Men
Recruiting
The goal of the proposed research is to design a peer-based community intervention focused on addressing internalized homophobia, internalized racism, HIV stigma, and peer BSMM support to increase PrEP initiation among BSMM in Prince George's County, MD. Participants will attend intervention events focused on stigma reduction and building community among Black queer men. Researchers will compare intervention and control group participants to see if there in a difference in PrEP initiation and ad... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: George Mason University, Fairfax, Virginia
Conditions: Hiv, Mental Health Issue, Support, Family
Water Intake and Weight Control in Older Adults
Recruiting
This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, ur... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
11/15/2023
Locations: Virginia Tech, Blacksburg, Virginia
Conditions: Overweight and Obesity
Cryospray Therapy for Benign Airway Stenosis
Recruiting
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: Virgnia Commonwealth University, Richmond, Virginia
Conditions: Stenosis Trachea
The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50
Recruiting
The purpose of this study is to determine the frequency of colorectal cancer in male and female endurance athletes between the ages of 35 and 50.
Gender:
All
Ages:
Between 35 years and 50 years
Trial Updated:
11/09/2023
Locations: Inova Schar Cancer Institute, Fairfax, Virginia
Conditions: Colorectal Cancer
Dermacyte® Amniotic Wound Care Liquid for the Treatment of Non-Healing Venous Stasis Ulcers
Recruiting
DL-VSU-201 is a randomized, double-blind, placebo controlled study in subjects with a non-infected venous stasis ulcer (VSU) that has failed to demonstrate improvement after receiving at least 4 weeks of standard, conventional wound therapy to evaluate the efficacy and safety of Dermacyte® Amniotic Wound Care Liquid (Dermacyte® Liquid).
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2023
Locations: Salem Vamc, Salem, Virginia
Conditions: Venous Stasis Ulcer, Venous Leg Ulcer