Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes
Recruiting
Phase I clinical trial to determine the Phase II dose of autologous TIL 1383I TCR gene modified T Cells using a retrovirus. This is a novel National Cancer Institute (NCI) funded investigator initiated therapy for patients with advanced melanoma.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
03/08/2018
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Melanoma
Treatment of Leishmaniasis With Impavido® (Miltefosine): Pregnancy Registry
Recruiting
The purpose of this observational study is to fulfill FDA Post Marketing Requirement (PMR) 2127-1 for miltefosine (NDA204684): implement a pregnancy registry for the time period Mar 2015-Mar 2024. This study is a prospective observational study in which female patients undergoing Impavido who become pregnant during treatment or within 5 months after completing treatment can volunteer to provide information about their pregnancy and the outcome of the pregnancy.
Gender:
Female
Ages:
All
Trial Updated:
03/06/2018
Locations: Fast Track, North Potomac, Maryland
Conditions: Leishmaniasis or Other Uses of Miltefosine
HealthEast Community Hip and Knee Replacement Registry
Recruiting
HealthEast Care System began the first community-based joint replacement registry (HJRR) in the U.S. in 1991, and now has more than 30,000 total joints registered. The purpose of the HJRR is to maintain and improve the care of individuals undergoing joint replacement surgery by providing timely information to their surgeons and the broader orthopaedic community. As it moves into the third decade, the HJRR is proud of its role in the development of the national American Joint Replacement Registr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2018
Locations: HealthEast Care System, Saint Paul, Minnesota
Conditions: Bone Fracture
SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
Recruiting
Locomotor, transport and information functions in human body systems are carried out by active media in autowave regimes! Any living organism is a (micro-macro-mega) hierarchy of autowave subsystems-an ensemble of loosely coupled subsystems of a simpler structure. From the highest levels of the hierarchy, Autowave Codes-Signals arrive, which determine the transitions of subsystems from one autowave regime to another Autowave interaction (of Complex Coherent Action). Autowave interaction is a pro... Read More
Gender:
All
Ages:
Between 1 month and 21 years
Trial Updated:
11/24/2017
Locations: World Autism Center, American Federation of Medical Synergetics, Department of Neurology; Cognitive Neurology/Neuropsychology WOMS, Louisville, Kentucky +1 locations
Conditions: Autistic Disorder, Autism Spectrum Disorder, Child Development Disorders, Pervasive, Neurodevelopmental Disorders, Mental Disorders, Asperger's Syndrome, Neurobehavioral Manifestations, Nervous System Diseases
Pembrolizumab + Idelalisib for Lung Cancer Study
Recruiting
This is a phase 1b/2 study to determine the safety and effectiveness of the combination of pembrolizumab and idelalisib in NSCLC patients whose disease has stopped responding to immune therapy. This study is being done to see if adding another immune modulator (idelalisib) to standard pembrolizumab will increase response rates, compared to the response seen with pembrolizumab alone.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2017
Locations: Georgia Cancer Center at Augusta University, Augusta, Georgia
Conditions: Non Small Cell Lung Cancer, Metastasis, Recurrence
The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry
Recruiting
The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry is a global, non-interventional, voluntary database that captures demographic and disease data directly from FOP patients and their caregivers via a secure, web-based patient portal. A physician portal (in development) will allow physicians to enter clinical data about their patients. The objectives are to organize the international FOP community for participation in clinical trials; to enable FOP patients worldwide to report da... Read More
Gender:
All
Ages:
All
Trial Updated:
08/15/2017
Locations: The International FOP Association, Casselberry, Florida
Conditions: Fibrodysplasia Ossificans Progressiva (FOP)
Development of Clinical Database of Individuals With Smith-Magenis Syndrome and Sleep Disturbances
Recruiting
This database will be used to better understand the sleep problems of people with SMS. This clinical database will be a part of a larger Smith-Magenis Patient Registry used to create an awareness campaign around SMS and the sleep disturbances that are characteristic of the disorder.
Gender:
All
Ages:
Between 3 years and 65 years
Trial Updated:
05/12/2017
Locations: Vanda Pharmaceuticals, Washington, D.C., District of Columbia
Conditions: Sleep Disturbances in Smith-Magenis Syndrome
Study of Tumor Tissue Samples From Patients Who Have Undergone Surgery for Advanced Stage III or Stage IV Ovarian Epithelial Cancer
Recruiting
This research study is looking at tumor tissue samples from patients who have undergone surgery for advanced stage III or stage IV ovarian epithelial cancer. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn how tumor infiltrating T cells can predict how patients will respond to treatment.
Gender:
Female
Ages:
All
Trial Updated:
05/02/2017
Locations: Gynecologic Oncology Group, Philadelphia, Pennsylvania
Conditions: Stage IIIA Ovarian Cancer, Stage IIIB Ovarian Cancer, Stage IIIC Ovarian Cancer, Stage IV Ovarian Cancer
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Recruiting
The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC), and if so, by what mechanism. Secondly, to characterize human intestinal microbial communities and their interactions with the host.
Gender:
All
Ages:
Between 2 weeks and 40 years
Trial Updated:
11/10/2016
Locations: Sacramento Pediatric Gastroenterology, Sacramento, California
Conditions: Primary Sclerosing Cholangitis, Biliary Atresia
Exercise and Brain Health
Recruiting
The risk of stroke and vascular dementia is high in individuals who have had a prior stroke or TIA, and in those who have vascular disease risk factors, such as high blood pressure, abnormal cholesterol, diabetes or pre-diabetes. These vascular risk factors can improve with exercise. This study will examine the impact of a 6 month, low intensity group exercise class on fitness, walking, balance, and brain health. This study will also collect fitness, walking, balance, and brain health outcome m... Read More
Gender:
All
Ages:
Between 18 years and 95 years
Trial Updated:
10/28/2016
Locations: Baltimore VA Medical Center, Baltimore, Maryland
Conditions: Stroke, Cardiovascular Risk Factors, Transient Ischemic Attack (TIA)
Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
Recruiting
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral... Read More
Gender:
All
Ages:
Between 4 years and 18 years
Trial Updated:
10/05/2016
Locations: Stanford University, Palo Alto, California
Conditions: Pediatric Acute-Onset Neuropsychiatric Syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections, PANS, PANDAS
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
Recruiting
This trial intends to gather very basic clinical information about keloid, its patterns of presentation, family history, ethnic background and correlation with the type of keloid, as well as prior treatment results that patients have had received.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/03/2016
Locations: Michael H. Tirgan, MD, New York, New York
Conditions: Keloid