Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
Recruiting
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. The newly formed HAEC Collaborative Research Group (HCRG) will utilize the 4 participating centers in the current consortia and recruit additional centers to enroll children diagnosed with Hirschsprung disease. 1a: To recruit 200 patients with Hirschsprung disease... Read More
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
08/10/2016
Locations: Cedars-Sinai Medical Center 8723 Alden Drive, Suite 240, Los Angeles, California
Conditions: Hirschsprung Disease, Enterocolitis
IRIS Registry: Intelligent Research in Sight Registry
Recruiting
The IRIS™ Registry (Intelligent Research in Sight) is the nation's first comprehensive eye disease clinical registry. The American Academy of Ophthalmology is developing it as part of the profession's shared goal of continual improvement in the delivery of eye care.The IRIS Registry will be a centralized system for ophthalmology practices to promote practice innovations and achieve clinical excellence.
Gender:
All
Ages:
6 months and above
Trial Updated:
07/11/2016
Locations: American Academy of Opthalmology, San Francisco, California
Conditions: Eye Diseases
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
Recruiting
The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for recurrent prostate cancer. This will provide a novel therapeutic approach to prostate cancer and hopefully impact on the development of metastatic disease and the control of preexisting metastasis.
Gender:
Male
Ages:
All
Trial Updated:
06/29/2016
Locations: Houston Methodist, Houston, Texas
Conditions: Prostatic Neoplasms
ACTHar in the Treatment of Lupus Nephritis
Recruiting
Systemic Lupus Erythematosus (SLE) is a disease in which the immune system attacks the healthy cells and tissues, causing inflammation that can damage organs in the body. About 50% of SLE patients experience inflammation in the kidneys. The purpose of this study is to determine the effectiveness and safety of two dosing arms of ACTHar gel in treating proliferative Lupus Nephritis (LN). This study hypothesizes that both dosing arms of ACTHar are safe and effective in treating proliferative LN (Cl... Read More
Gender:
All
Ages:
16 years and above
Trial Updated:
03/17/2016
Locations: Columbia University - Herbert Irving Pavilion, New York, New York
Conditions: Lupus Nephritis
Alzheimer's Disease Core Center
Recruiting
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patient... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
06/10/2015
Locations: University of Arizona, University Medical Center, Tucson, Arizona
Conditions: Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders
Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence
Recruiting
Most pediatric patients with solid tumors respond to initial high-dose, intensive therapy and complete treatment in remission. High-risk patients however, frequently have recurrent disease which is then treated with ad hoc regimens or early phase therapies with little benefit to the patient. Metronomic therapy (MC), defined as lower dose continuous drug exposure, has been successfully tested in pediatric leukemias with excellent results in terms of improved outcome, toxicity profiles, and cost.... Read More
Gender:
All
Ages:
Between 12 months and 31 years
Trial Updated:
05/13/2015
Locations: Miller Children's and Women's Hospital Long Beach, Long Beach, California +1 locations
Conditions: Solid Tumor
Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy
Recruiting
In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to the commonly-used standard 3D-conformal external beam radiotherapy, spares more normal breast and lung tissue, and may lead to improved clinical outcomes.
Gender:
All
Ages:
40 years and above
Trial Updated:
06/24/2014
Locations: Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado +4 locations
Conditions: Breast Cancer
Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis
Recruiting
RATIONALE: Congenital toxoplasmosis is an infection caused by the parasitic organism Toxoplasma gondii, and it may be passed from an infected mother to her unborn child. The mother may have mild symptoms or no symptoms; the fetus, however, may experience damage to the eyes, nervous system, skin, and ears. The newborn may have a low birth weight, enlarged liver and spleen, jaundice, anemia, petechiae, and eye damage. Giving the antiparasitic drugs pyrimethamine and sulfadiazine is standard treatm... Read More
Gender:
All
Ages:
All
Trial Updated:
05/13/2009
Locations: University of Chicago, Chicago, Illinois
Conditions: Toxoplasmosis