The Healthy Elderly Longevity Cohort
Recruiting
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be discovered that affect "common" diseases that have multi-gene architecture with variable penetrance such as breast cancer, diabetes mellitus, and coronary artery disease. This change took place because investigators now have the tools to illuminate the whole genome at on... Read More
Gender:
All
Ages:
80 years and above
Trial Updated:
03/16/2020
Locations: Scripps Translational Science Institute, La Jolla, California
Conditions: Healthy
TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory
Recruiting
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD). This study will use repetitive Transcranial Magnetic Stimulation (rTMS) to stimulate nodes of the Default Mode Network (DMN)- which is thought to support episodic memory and to be affected by Alzheimer's pathology. We will use functional connectivity MRI (fcMRI) to assess c... Read More
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
03/11/2020
Locations: Massachuetts General Hospital, Charlestown, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Aging
Metformin in Heart Failure Without Diabetes
Recruiting
Columbia University Medical Center is conducting a pilot clinical research study that will assess the use of the medication metformin for heart failure in patients who are not diabetic and have no evidence of insulin resistance. Patients will received either the study drug metformin or placebo for 4 months. During the study, the patients will undergo extensive testing that will include symptom assesment, exercise capacity, echocardiography, cardiac PET imaging and blood tests.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/06/2020
Locations: New York Hospital - Columbia University Irving Medical Center, New York, New York
Conditions: Heart Failure
The Genetics of Polycystic Ovarian Syndrome
Recruiting
The goal of this study is to determine the genetic basis of polycystic ovary syndrome (PCOS). We will first look for genes in the Icelandic population, where large family trees are known and it is easier to search for genes. We will then determine whether these same genes are important in U.S. PCOS patients.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/01/2020
Locations: University of Utah, Salt Lake City, Utah
Conditions: Polycystic Ovary Syndrome
DeBakey Cardiovascular Magnetic Resonance Study
Recruiting
While advancements in cardiac magnetic resonance (CMR) have improved image quality, it is unclear how these improvements are connected to the clinical evaluation of individuals with cardiovascular disease. The aim of this large prospective registry revolves around 4 key principles: 1) utilize CMR to gain additional pathophysiologic insights into cardiovascular disease, 2) understand how CMR compares to alternative cardiovascular diagnostic modalities, 3) determine how CMR affects clinical manage... Read More
Gender:
All
Ages:
All
Trial Updated:
02/19/2020
Locations: Houston Methodist Hospital, Houston, Texas
Conditions: Cardiovascular Diseases
Complementary and Alternative Care in Multiple Sclerosis
Recruiting
This is a prospective, observational study designed to describe disease progression, symptom change, quality of life, diet and lifestyle habits, and frequency of adverse events among patients with multiple sclerosis (MS) who use complementary and alternative medicine (CAM). In addition to describing the patterns of CAM use, this study will also identify and describe the positive deviants, those individuals with the highest quality of life and least amount of disease activity. Positive deviants w... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
02/07/2020
Locations: Bastyr University Clinical Research Center, Kenmore, Washington
Conditions: Multiple Sclerosis
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Recruiting
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/04/2020
Locations: University of Washington Eye Institute at Harborview, Seattle, Washington
Conditions: Chalazion
Establishment of a Parathyroid Tissue Bank
Recruiting
To develop a tissue bank library for patients with parathyroid disease who have undergone surgery and/or biopsy, and/or who may undergo surgical intervention at M. D. Anderson Cancer Center or outside centers, and/or all patients seen through the Parathyroid Center at participating sites, whether or not the patients undergo treatment for their disease. The tissue bank will contain both normal parathyroid tissue and diseased tissue, and will provide a resource for the ongoing study of parathyroid... Read More
Gender:
All
Ages:
All
Trial Updated:
01/24/2020
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Parathyroid Disease
Caris Biorepository Research Protocol
Recruiting
The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients. The Caris Biorepository is a repository of prospectively collected biological specimens and associated clinical and demographic data gathered from multiple sources to be stored, used and shared for research. Caris Life Sciences will maintain the data and specimens... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/21/2020
Locations: Phoebe Putney Memorial Hospital, Albany, Georgia +6 locations
Conditions: Cancer
A Trial Evaluating Patient Preference of Dropless vs Drops Post Cataract Surgery
Recruiting
To evaluate the safety and ocular efficacy of Dextenza in combination with an intracameral antibiotic and NSAID in controlling post-operative ocular pain and inflammation compared to standard of care topical therapy in patients undergoing bilateral cataract surgery.
Gender:
All
Ages:
Between 22 years and 100 years
Trial Updated:
12/17/2019
Locations: Ophthalmic Consultants of Long Island, Garden City, New York
Conditions: Patient Preference
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Sutter Health/Alta Bates Summitt Medical Center, Oakland, California +17 locations
Conditions: Mitral Valve Insufficiency
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Recruiting
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized. The percutaneous approach will be offered to participants with a posterior placenta. The laparotomy/uterine exteriorization approach will be offered to participants regardless of placental location.
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/11/2019
Locations: University of Southern California / Huntington Memorial Hospital, Los Angeles, California +1 locations
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation