IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer
Recruiting
A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte environment during oocyte retrieval, use of oral medications and very low doses of FSH, and delayed embryo transfer during subsequent warmed cryo-preserved embryo transfer. Eligible patient have a PCO pattern in their ovaries during transvaginal ultrasound.
Gender:
Female
Ages:
Between 18 years and 38 years
Trial Updated:
10/31/2019
Locations: Brown Fertility, Jacksonville, Florida
Conditions: Polycystic Ovary Syndrome
DC Longitudinal Study on Aging and Specimen Bank
Recruiting
The Georgetown University Memory Disorders Program, part of the Department of Neurology, is conducting pilot studies of the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. Further, this study is assessing longitudinal changes in biological, lifestyle, and cognitive assessment collection. The primary goal of this study is to examine the feasibility of biochemical assays, genetic testing, and cognitive and lifestyle... Read More
Gender:
All
Ages:
45 years and above
Trial Updated:
10/23/2019
Locations: Georgetown University Memory Disorders Program, Washington, District of Columbia
Conditions: Alzheimer Disease, Dementia, Mild Cognitive Impairment, Aging, Aging Disorder
Risk Factors for Thrombosis in Children With Central Venous Lines
Recruiting
This project addresses the role of lab markers around the time of central line placement in predicting risk of thrombosis in pediatric patients with central venous lines being placed. The project proposes an innovative way to predict higher risk of thrombosis in the pediatric population to give clinicians a valid tool to guide clinical practice for these patients.
Gender:
All
Ages:
Between 6 months and 17 years
Trial Updated:
10/04/2019
Locations: University of Arizona, Tucson, Arizona
Conditions: Pediatric Venous Thromboembolism
Optimizing Pain Control in Transurethral Resection of the Prostate
Recruiting
The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard of care which includes opioids as the primary agent. The investigators believe this is an important step in reducing the opioid epidemic in surgical patients.
Gender:
Male
Ages:
18 years and above
Trial Updated:
09/25/2019
Locations: Virginia Mason Medical Center, Seattle, Washington
Conditions: Pain, BPH With Urinary Obstruction, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
TearCare System to Treat Dry Eye Disease
Recruiting
In this study, the TearCare System will be compared with the LipiFlow Thermal Pulsation System in patients with dry eye disease. The objective is to demonstrate that the TearCare System is safe and effective in relieving the signs and symptoms of dry eye disease. NOTE: All sites have been selected for this study. We are not seeking additional sites at this time.
Gender:
All
Ages:
22 years and above
Trial Updated:
09/17/2019
Locations: Center for Excellence in Eye Care, Miami, Florida
Conditions: Dry Eye, Meibomian Gland Dysfunction
Comprehensive Data Collection and Follow-Up for Patients With Thyroid, Parathyroid and Adrenal Disease
Recruiting
The goal of this data review study is to collect data to learn more about thyroid, parathyroid, and adrenal disease.
Gender:
All
Ages:
All
Trial Updated:
09/13/2019
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Endocrine Disease
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
Recruiting
A number of drugs used in the perioperative period may cause prolongation of the QT interval on the electrocardiogram (EKG). These drugs include inhalational agents, antiemetic agents, pain medications, and drugs used to reverse the effects of muscle relaxants. Approximately 80% of patients undergoing a general anesthetic will demonstrate significant prolongation of the QT interval on the EKG in the postanesthesia care unit (PACU) following surgery. The concern with QT interval prolongation is t... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/11/2019
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: EKG-QT Prolongation
Efficacy of 300mg Ibuprofen Prolonged-Release Tablets for the Treatment of Pain After Surgical Removal of Impacted Third Molars
Recruiting
This is a single centre, randomised, double-blind, double-dummy, parallel group, multiple-dose, active and placebo-controlled efficacy study to evaluate the efficacy and safety of 2×300mg ibuprofen Prolonged Release (PR) tablets in subjects with postoperative dental pain.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2019
Locations: JBR Clinical Research, Salt Lake City, Utah
Conditions: Pain
Alveolar Macrophage Programming Following Endotoxin Exposure
Recruiting
The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players i... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/19/2019
Locations: National Jewish Health, Denver, Colorado
Conditions: ARDS, Human
The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity
Recruiting
Current American College of Cardiology/American Heart Association guidelines recommend that patients with severe degenerative mitral regurgitation be considered for mitral valve surgery. There remains a debate within the cardiology community regarding the appropriate management of patients who remain asymptomatic. In this study the investigators will perform longitudinal follow-up data with cardiac MRI to inform the prophylactic surgery vs. close follow-up debate and to better define the natural... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/19/2019
Locations: Morristown Medical Center, Morristown, New Jersey
Conditions: Mitral Regurgitation
Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study
Recruiting
The goal of this pilot study is to explore the efficacy of chloroquine in terminating persistent AF and assess its potential role as a pharmacological cardioversion agent for the management of AF.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/15/2019
Locations: University of South Florida, Tampa, Florida
Conditions: Atrial Fibrillation
tSCI Contrast Enhanced Ultrasound Study
Recruiting
Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypo-perfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/12/2019
Locations: Harborview Medical Center, Seattle, Washington
Conditions: Acute Spinal Cord Injury