IRIS Registry: Intelligent Research in Sight Registry
NCT02485847
Recruiting
The IRIS™ Registry (Intelligent Research in Sight) is the nation's first comprehensive eye disease clinical registry. The American Academy of Ophthalmology is developing it as part of the profession's shared goal of continual improvement in the delivery of eye care.The IRIS Registry will be a centralized system for ophthalmology practices to promote practice innovations and achieve clinical excellence.
Gender:
All
Ages:
6 months and above
Locations: American Academy of Opthalmology, San Francisco, California
Conditions: Eye Diseases
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Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
NCT00673842
Recruiting
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior 5 years, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.
Gender:
All
Ages:
Between 18 years and 80 years
Locations: Heart Center Research LLC, Huntsville, Alabama +93 locations
Conditions: Myocardial Infarction, Sudden Death
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HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
NCT01913106
Recruiting
The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for recurrent prostate cancer. This will provide a novel therapeutic approach to prostate cancer and hopefully impact on the development of metastatic disease and the control of preexisting metastasis.
Gender:
Male
Ages:
All
Locations: Houston Methodist, Houston, Texas
Conditions: Prostatic Neoplasms
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Colony-Stimulating Factor-1 (CSF-1) and Other Cytokines in Human Endometrial Carcinogenesis
NCT00250770
Recruiting
The purposes of this study are the following: To further characterize and quantify both CSF-1 and colony-stimulating factor-1 receptor (CSF-1R) expression from additional tumor specimens, specifically, tumors of high grade and from metastatic sites. To assay using Enzyme-Linked ImmunoSorbent Assay (ELISA) sandwich monoclonal antibody methodology, CSF-1 expression in the peritoneal fluid and blood from patients with endometrial adenocarcinomas. Using immunohistochemistry, to evaluate the presenc... Read More
Gender:
Female
Ages:
All
Locations: University of New Mexico, Albuquerque, New Mexico
Conditions: Uterine Neoplasms, Endometrial Neoplasms
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Transcatheter Aortic Valve Replacement System Pivotal Trial
NCT02163850
Recruiting
Prospective, randomized, unblinded, multi-center investigational study with enrollment at up to 45 investigational sites. The study is designed to compare the study device (Direct Flow Medical Transcatheter Aortic Valve System) composite event rate to a blended commercial comparator (using approved Medtronic self-expanding bioprosthesis or Edwards balloon-expandable bioprosthesis) in high and extreme risk Subjects with severe symptomatic aortic stenosis. Subjects will be followed through the ind... Read More
Gender:
All
Ages:
All
Locations: NewYork-Presbyterian / Columbia Univ., New York, New York +2 locations
Conditions: Aortic Valve Stenosis
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Evaluation of Truebeam for Low-Intermediate Risk Prostate Cancer
NCT01581749
Recruiting
The primary safety purpose of this study is to estimate the rates of immediate and long-term high grade (grade 3-5) gastrointestinal and genitourinary side effects during the five years after TrueBeam stereotactic body radiotherapy in low-risk and intermediate-risk prostate cancer patients. The primary efficacy purpose is to compare 5 year biochemical disease free survival rates with TrueBeam to 5 year biochemical diseases free survival rates with dose-escalated external beam radiation therapy.
Gender:
Male
Ages:
21 years and above
Locations: Lankenau Medical Center, Radiation Oncology, Wynnewood, Pennsylvania
Conditions: Prostate Neoplasms
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ACTHar in the Treatment of Lupus Nephritis
NCT02226341
Recruiting
Systemic Lupus Erythematosus (SLE) is a disease in which the immune system attacks the healthy cells and tissues, causing inflammation that can damage organs in the body. About 50% of SLE patients experience inflammation in the kidneys. The purpose of this study is to determine the effectiveness and safety of two dosing arms of ACTHar gel in treating proliferative Lupus Nephritis (LN). This study hypothesizes that both dosing arms of ACTHar are safe and effective in treating proliferative LN (Cl... Read More
Gender:
All
Ages:
16 years and above
Locations: Columbia University - Herbert Irving Pavilion, New York, New York
Conditions: Lupus Nephritis
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A Multicenter Study of Active Specific Immunotherapy With OncoVax® in Patients With Stage II Colon Cancer
NCT02448173
Recruiting
OncoVAX® is the first cancer vaccine that both prevents cancer recurrence and addresses the diversity of cancer cells. In this pivotal randomized, multicenter Phase IIIb study in patients with Stage II colon cancer, OncoVAX is designed to use a patient's own cancer cells to mobilize the body's immune system to prevent the return of colon cancer following surgery.
Gender:
All
Ages:
18 years and above
Locations: Halifax Health Medical Center, Port Orange, Florida
Conditions: Stage II Colon Cancer
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Anesthesia Quality Institute National Anesthesia Clinical Outcomes Registry
NCT02504970
Recruiting
The Anesthesia Quality Institute (AQI) is home to the National Anesthesia Clinical Outcomes Registry (NACOR), a data warehouse that has been designated as a Qualified Clinical Data Registry (QCDR) by the Centers for Medicare and Medicaid Services (CMS) for Physician Quality Reporting System (PQRS) reporting. With 20 million cases and growing, Anesthesia Quality Institute's clinical data provides an evidence-based rational that informs treatment choices and helps control treatment costs. Nationa... Read More
Gender:
All
Ages:
All
Locations: Anesthesia Quality Institute, Schaumburg, Illinois
Conditions: Anesthesia
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Alzheimer's Disease Core Center
NCT01421420
Recruiting
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patient... Read More
Gender:
All
Ages:
50 years and above
Locations: University of Arizona, University Medical Center, Tucson, Arizona
Conditions: Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders
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Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence
NCT02446431
Recruiting
Most pediatric patients with solid tumors respond to initial high-dose, intensive therapy and complete treatment in remission. High-risk patients however, frequently have recurrent disease which is then treated with ad hoc regimens or early phase therapies with little benefit to the patient. Metronomic therapy (MC), defined as lower dose continuous drug exposure, has been successfully tested in pediatric leukemias with excellent results in terms of improved outcome, toxicity profiles, and cost.... Read More
Gender:
All
Ages:
Between 12 months and 31 years
Locations: Miller Children's and Women's Hospital Long Beach, Long Beach, California +1 locations
Conditions: Solid Tumor
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Basal Joint Arthritis Prospective
NCT01376024
Recruiting
The study hypothesizes that there exist effective non-operative and operative treatments for certain patient populations with basal joint arthritis of the thumb. There also exists a functionally superior, cost effective, and low risk non-operative or minimally invasive operative treatment regime to alleviate pain and slow the progression of disease in those with less advanced disease. Likewise, there is significant functional, health utility, and economic advantage to surgically treating advance... Read More
Gender:
All
Ages:
18 years and above
Locations: Columbia University/NY Presbyterian Hospital, New York, New York
Conditions: Osteoarthrosis of the Carpometacarpal Joint of the Thumb
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