Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical Trials
Recruiting
This is a global, prospective, multi-center study that is designed to assess the long-term safety and efficacy of OAV101 in patients who participated in an OAV101 clinical trial. The assessments of safety and efficacy in Study COAV101A12308 will continue for 15 years from the date of OAV101 administration in the previous clinical trial.
Gender:
All
Ages:
All
Trial Updated:
05/22/2024
Locations: Child Hosp of the Kings Daughters, Norfolk, Virginia +19 locations
Conditions: Spinal Muscular Atrophy (SMA)
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
Recruiting
To determine the recommended phase 2 dose (RP2D) of the combination of neratinib and sodium valproate when given to patients with advanced solid tumors. Then to explore the antitumor effects of the neratinib and sodium valproate combination in advanced solid tumors with attention to RAS-mutated tumors, EGFR-altered GBM, and ocular melanoma, as part of the phase 2 expansion cohort.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia
Conditions: Solid Tumor, Adult
Preventing Firearm Violence in Youth: A Hospital-based Prevention Strategy
Recruiting
The goal of the study is to understand if hospital-based violence interventions are effective for reducing youth violence among violently injured youth. This study will allow researchers to learn more about the intervention's effectiveness. The researchers also want to understand if the violence intervention impacts other behaviors, such as firearm use, drug use, aggression, risky behaviors, and rates of violent re-injury.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
05/20/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Violence in Adolescence
Examining Lateralized Aspects of Motor Control Using Non-invasive Neural Stimulation
Recruiting
Motor adaptation and generalization are believed to occur via the integration of various forms of sensory feedback for a congruent representation of the body's position in space along with estimation of inertial properties of the limb segments for accurate specification of movement. Thus, motor adaptation is often studied within curated environments incorporating a "mis-match" between different sensory systems (i.e. a visual field shift via prism googles or a visuomotor rotation via virtual real... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
05/20/2024
Locations: Virginia Commonwealth University Medical Center, Richmond, Virginia
Conditions: Motor Adaptation and Generalization, Posterior Parietal Cortex, Cerebellum
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
Recruiting
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes. AP technology is a system of devices that closely mimics the glucose-regulating function of a healthy human pancreas. It includes an insulin pump and a continuous glucose monitor (CGM). In this study, the investigators will research whether improvements in blood glucose levels and blood glucose variability will in turn decrease biomarkers of inflammation and end... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
05/20/2024
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Type 1 Diabetes
Decreasing Long-term Opioid Use in Cancer Survivors
Recruiting
This is a feasibility pilot trial assessing a behavioral intervention for chronic pain among disease-free cancer survivors to decrease long-term opioid dependence.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Pain, Chronic Pain, Cancer Pain, Survivorship
Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
Recruiting
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuropathic Pain
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease
Recruiting
This is an open-label multi-center study to evaluate safety and biomarkers of efficacy of a single dose of intravenously-administered AMT-191. The study will also include exploratory functional efficacy assessments. The plan is to investigate 2 sequential dose cohorts in 3-6 Participants per cohort. Participants will be monitored for 24 hours following AMT-191 administration then follow-up study visits will continue for 24 months, during which safety, pharmacokinetics/pharmacodynamics, biomarker... Read More
Gender:
Male
Ages:
Between 18 years and 50 years
Trial Updated:
05/16/2024
Locations: Lysosomal & Rare Disorders Research and Treatment Center, Inc, Fairfax, Virginia
Conditions: Fabry Disease
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
Recruiting
The term "Overlap Syndrome" (OS) is used to describe the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single patient. Due to premature aging, patients with OS are prone to developing functional decline up to 20 years earlier than the general population. The International Classification of Functioning, Disability and Health (ICF) evaluates functional status in chronic pulmonary disease globally in 5 domains. The investigators propose to stud... Read More
Gender:
All
Ages:
All
Trial Updated:
05/15/2024
Locations: Salem VA Medical Center, Salem, VA, Salem, Virginia
Conditions: COPD, OSA
MDTRP Neuromuscular Research Biobank
Recruiting
The purpose of this research repository is to collect, store, and share with other researchers any tissues that subjects with all types of neuromuscular disease are willing to donate. These samples will be stored at Virginia Commonwealth University (VCU) and will be used for future research with this population.
Gender:
All
Ages:
75 years and below
Trial Updated:
05/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuromuscular Diseases, Neuromuscular Disorder, Neuromuscular Diseases in Children
Long-Term Development of Muscular Dystrophy Outcome Assessments
Recruiting
This is a 24-month, observational study of up to 1000 participants with Limb Girdle Muscular Dystrophy (LGMD), Myotonic Dystrophy Type 2 (DM2), and late onset Pompe disease (LOPD).
Gender:
All
Ages:
Between 6 years and 50 years
Trial Updated:
05/13/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: LGMD1B, LGMD1C, LGMD1D, LGMD1E, LGMD1F, LGMD1G, LGMD1H, LGMD2A, LGMD2B, LGMD2C, LGMD2D, LGMD2E, LGMD2F, LGMD2G, LGMD2I, LGMD2J, LGMD2K, LGMD2L, LGMD2M, LGMD2N, LGMD2O, LGMD2P, LGMD2Q, LGMD2S, LGMD2T, LGMD2U, LGMD2W, LGMD2X, LGMD2Y
Insula Neuromodulation for Chronic Neuropathic Pain
Recruiting
This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/10/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Neuropathic Pain, Chronic Pain