Istradefylline Effect Protocol on Parkinson's Disease Tremor
Recruiting
This is an investigator-initiated trial. In this 6-month open label, single arm, exploratory pilot study, the investigator intends to enroll a pilot sample of 25 patients with Parkinson's disease who are being started on the novel FDA approved medication "Istradefylline'' as an add on therapy for management of their motor symptoms (based on the judgment of the movement disorders specialist, if patients are in sub-optimal management of their symptoms on maximum tolerable dose of their dopaminergi... Read More
Gender:
All
Ages:
18 years and above
Locations: Georgetown University Hospital, McLean, Virginia
Conditions: Parkinson Disease, Tremor
Simplified Post Op Rehabilitation for Ankle and Pilon Fractures
Recruiting
The aim of this study is to compare standard post operative rehabilitation with a simplified wooden block stretching protocol that will yield similar results.
Gender:
All
Ages:
Between 18 years and 65 years
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Ankle Fractures, Pilon Fracture
A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
Recruiting
The purpose of this study is to test the safety and tolerability of HFB200603 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participants will receive increasing doses of HFB200603 as a monotherapy or in combination with tislelizumab until a safe and tolerable dose of HFB200603 as a single agent or combination therapy is determined. During the expansion part, participants will take... Read More
Gender:
All
Ages:
18 years and above
Locations: New Experimental Therapeutics of Virginia - NEXT Oncology, Fairfax, Virginia
Conditions: Renal Cell Carcinoma, Melanoma, Non Small Cell Lung Cancer, Gastric Cancer, Colorectal Cancer
Preventing Firearm Violence in Youth: A Hospital-based Prevention Strategy
Recruiting
The goal of the study is to understand if hospital-based violence interventions are effective for reducing youth violence among violently injured youth. This study will allow researchers to learn more about the intervention's effectiveness. The researchers also want to understand if the violence intervention impacts other behaviors, such as firearm use, drug use, aggression, risky behaviors, and rates of violent re-injury.
Gender:
All
Ages:
Between 10 years and 17 years
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Violence in Adolescence
Impact of Reading on Endogenous Oxytocin System of Preterm Infants
Recruiting
The purpose of this study is to learn how early language exposure may be related to changes in DNA in parents and their premature infants. While a person's genetic code is determined at the time of conception, the way that some genes are expressed in the body can be changed even after an individual is born. These changes are called epigenetic changes. In this study, the investigators want to learn about the epigenetic changes that happen after a premature baby is born and whether a parent's inte... Read More
Gender:
All
Ages:
33 weeks and below
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Premature Infant Disease, Development, Infant
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
Recruiting
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
Gender:
All
Ages:
Between 25 years and 50 years
Locations: University of Virginia, Division of Nephrology; Center for Immunity, Inflammation & Regenerative Medicine, Charlottesville, Virginia
Conditions: Healthy Subjects
Predicting Outcomes in Nonalcoholic Steatohepatitis With Advanced Fibrosis
Recruiting
Nonalcoholic Steatohepatitis (NASH) is a condition with increased amount of fat, inflammation and scarring in the liver. In compensated cirrhosis, the liver is coping with this damage and maintaining its important functions. Decompensation occurs when the liver becomes unable to perform all of its functions adequately. Variceal hemorrhage (bleeding from abnormal vessels in the liver called varices), Ascites (abnormal build-up of fluid in the abdomen), and Encephalopathy (brain confusion as a res... Read More
Gender:
All
Ages:
18 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Nonalcoholic Steatohepatitis
Vaccination With 6MHP, With or Without Systemic CDX-1127, in Patients With Stage II-IV Melanoma
Recruiting
This study evaluates whether it is safe to administer a peptide vaccine (6MHP) with adjuvants and the CDX-1127 monoclonal antibody, and whether the adjuvants and the CDX-1127 monoclonal antibody boost immune responses to the vaccine. In this study, the adjuvants are Montanide ISA-51 and polyICLC. The investigators will monitor these effects by performing tests in the laboratory on participants' blood and tissue from a vaccine site.
Gender:
All
Ages:
18 years and above
Locations: University of Virginia, Charlottesville, Virginia +1 locations
Conditions: Melanoma
Fasting Versus Non-fasting on Outcomes and Satisfaction Prior to Cardiac Catheterization
Recruiting
Moderate sedation is used in the catheterization laboratory relieve the anxiety and discomfort associated with access and other aspects of the procedure. Whether being in a fasting state (nothing per os, NPO) at the time of the procedure is beneficial or harmful is not well known, but patients are typically required to be fasting at the time of elective procedures, guidance derived from procedures that require general anesthesia. Whereas the typical thinking was that fasting prior to procedures... Read More
Gender:
All
Ages:
18 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Diseases
Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)
Recruiting
The PRIMER (Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy) trial is a pilot designed to estimate the feasibility of integrating a home-based pre-operative exercise and mindfulness program (pre-habilitation program) for patients scheduled to undergo radical cystectomy for bladder cancer in an attempt to improve both physical and psychological conditioning pre-operatively.
Gender:
All
Ages:
Between 18 years and 90 years
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Bladder Cancer, Non-muscle-invasive Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS
Recruiting
The purpose of this study is to estimate the potential benefit of early and continued palliative care (PC) consultation on end of life issues.
Gender:
All
Ages:
18 years and above
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Leukemia, Acute, AML, Adult, ALL, Adult, Myelodysplastic Syndromes
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Recruiting
To determine feasibility of recruitment and tolerability of treatment with sacubitril-valsartan among adult age survivors of cancer diagnosed at or before age 39 who have stage B heart failure.
Gender:
All
Ages:
Between 18 years and 120 years
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Failure, Heart Dysfunction