PENG vs FICB for Hip Fracture in ED Patients
Recruiting
Regional anesthesia for hip fractures has been shown to decrease rates of delirium in elderly patients with hip fractures as well as improve pain compared to systemic opioids. The Pericapsular Nerve Group (PENG) block has recently received attention as an alternative approach to femoral nerve block and Fascia Iliaca Compartment Block (FICB). The investigators seek to evaluate if there is a difference between the PENG and FICB in terms of efficacy of pain control in ED patients presenting with hi... Read More
Gender:
All
Ages:
18 years and above
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Femoral Neck Fractures, Intertrochanteric Fractures
Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease
Recruiting
The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Participants will be randomly assigned to a 12-week course of the study drug, dapagliflozin 10mg, or placebo. Blood flow in the heart will be assessed using stress cardiac magnetic resonance imaging at basel... Read More
Gender:
Female
Ages:
Between 18 years and 99 years
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Myocardial Ischemia
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
Recruiting
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
Gender:
All
Ages:
Between 18 years and 55 years
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Obesity, Insulin Resistance, Cardiovascular Risk Factor
Artificial Pancreas - Adolescent Physiology & Psychology Longitudinal Evaluation
Recruiting
This study designed to assess changes in control of Type 1 Diabetes in pubertal adolescents over a two year period. There are two arms/substudies, the first being a longitudinal randomized controlled trial and the second an observational study.
Gender:
All
Ages:
Between 11 years and 12 years
Locations: University of Virginia Center for Diabetes Technology, Charlottesville, Virginia
Conditions: Type 1 Diabetes
PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction
Recruiting
This study is trying to find out whether performing a hybrid aerobic-resistance exercise training program (titled PRIME: Peripheral Remodeling via Intermittent Muscular Exercise) results in better health outcomes than the traditional exercise training program (called COMBO) that is used in individuals with heart failure with reduced ejection fraction (HFrEF). Participants will be randomized (like the flip of a coin) to either PRIME (investigational) or the traditional exercise program (standard... Read More
Gender:
All
Ages:
65 years and above
Locations: University of Virginia, Department of Kinesiology, Charlottesville, Virginia
Conditions: Heart Failure With Reduced Ejection Fraction
Feasibility Trial of a Multi-level Media Production and Social Marketing Campaign to Reduce HPV Vaccine Hesitancy
Recruiting
Since 2019, the HPV working group of the University of Virginia Cancer Center's Southwest Virginia Community Advisory Board has developed and executed strategies to increase regional HPV vaccination rates. Members collaboratively developed Appalachian Voices for Health, a multi-level media production and social marketing intervention. This novel intervention builds on the past efforts of the working group and the engaged organizations; takes into account the impact of vaccine hesitancy on HPV va... Read More
Gender:
All
Ages:
18 years and above
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Human Papillomavirus Infection, Vaccination Hesitancy
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
Recruiting
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/... Read More
Gender:
All
Ages:
18 years and above
Locations: UVA Center for Leading Edge Addiction Research, Charlottesville, Virginia
Conditions: Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Lived Experiences of Black Girls in Richmond
Recruiting
This study is to understand the quality of life of Black Girls in Richmond, Virginia, which includes generating a report about the status of Black girls in Richmond. Research or reports about the state of the girls are growing more common across the country in cities like Los Angeles, Chicago, and Philadelphia. Most of these studies generate deficit narratives focusing on these groups' problems, needs, and deficiencies. Fewer studies focus solely on the experience of Black girls specifically. Th... Read More
Gender:
All
Ages:
12 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Black or African American
Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes
Recruiting
This study is evaluate the superior efficacy of a Continuous Glucose Monitor (CGM)-based advisory system in Type 1 Diabetes Mellitus (T1DM), as compared to Sensor Augmented Mode (SAM) therapy, and with characterizing the impact of psycho-behavioral factors on system performance, which will enable system individualization and lead to automated adaptation of advice delivery to optimize glycemic control and reduce the system's psychological impact.
Gender:
All
Ages:
18 years and above
Locations: University of Virginia Center for Diabetes Technology, Charlottesville, Virginia
Conditions: Diabetes Mellitus, Type 1
Insula Neuromodulation for Chronic Neuropathic Pain
Recruiting
This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.
Gender:
All
Ages:
Between 18 years and 75 years
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Neuropathic Pain, Chronic Pain
Focused Ultrasound (FUS) Mesencephalotomy for Head & Neck Cancer Pain
Recruiting
This proposed pilot study will investigate the safety and initial effectiveness of focused ultrasound lesioning of the contralateral mesencephalon for severe, opioid-resistant pain associated with head and neck cancer
Gender:
All
Ages:
Between 18 years and 75 years
Locations: University of Virginia UVA Health, University Hospital, Charlottesville, Virginia
Conditions: Cancer of Head and Neck, Pain, Face, Pain, Neck
A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
Recruiting
The purpose of this study is to estimate and compare the incidence of overall malignancy, serious infection, and opportunistic infections between new users of ustekinumab and new users of other biologic therapies among adult participants with Crohn's disease (CD) or ulcerative colitis (UC).
Gender:
All
Ages:
18 years and above
Locations: NMCP, Portsmouth, Virginia
Conditions: Crohn Disease, Colitis, Ulcerative