Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
Recruiting
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education condition on sleep and cognition. Internet-based recr... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/06/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders, Sleep Disorders, Intrinsic, Dyssomnias, Sleep Wake Disorders, Nervous System Diseases, Alzheimer Disease
Assessing Physical Function in Sickle Cell Patients Taking Voxelotor
Recruiting
Voxelotor is a novel hemoglobin polymerization inhibitor which has been demonstrated to reduce hemolysis and improve hemoglobin levels. There have been numerous studies examining the clinical impact of voxelotor in sickle cell disease (SCD) patients, but there are few published reports on the effects of treatment on physical function in patients with SCD. The hypothesis to be tested is that anemic SCD patients will have improvements in performance after 6 months of voxelotor treatment.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/06/2024
Locations: Inova Schar Cancer Institute, Falls Church, Virginia
Conditions: Sickle Cell Disease
Trans-Abdominal Fetal Pulse Oximetry - EFS-IDE
Recruiting
The Lumerah System, developed and manufactured by Raydiant Oximetry, Inc., is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy. The Lumerah System is intended as an adjunct to cardiotocography. In this study, women in labor will also be simultaneously monitored with a re-engineered version of the previously approved transvaginal oximeter sensor connected to a Nellcor N-400 fetal oximetry monitor... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Sentara Norfolk General - Eastern Virginia Medical School, Norfolk, Virginia
Conditions: Fetal Hypoxia, Fetal Distress, Fetal Conditions, Fetal Complications, Labor Fetal Anoxia, Labor (Obstetrics)--Complications, Oxygen Deficiency
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
Recruiting
The purpose of this study is to evaluate the efficacy and safety of lutetium (177Lu) vipivotide tetraxetan (AAA617) in participants with oligometastatic prostate cancer (OMPC) progressing after definitive therapy to their primary tumor. The data generated from this study will provide evidence for the treatment of AAA617 in early-stage prostate cancer patients to control recurrent tumor from progressing to fatal metastatic disease while preserving quality of life by delaying treatment with androg... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/02/2024
Locations: Virginia Oncology Associates ., Norfolk, Virginia +12 locations
Conditions: Oligometastatic Prostate Cancer (OMPC)
Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
Recruiting
Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.
Gender:
All
Ages:
21 years and above
Trial Updated:
05/01/2024
Locations: University of Virginia, Charlottesville, Virginia +1 locations
Conditions: Heart Failure
Preventing Retaliatory Gun Violence in Violently Injured Adults
Recruiting
The purpose of this research study is to find out if a hospital-based violence intervention (Bridging the Gap) is effective for reducing violence. The researchers think that adults who receive Bridging the Gap will see greater improvements than those who do not receive the intervention. This study will allow them to learn more about the intervention's effectiveness. The study will also help them understand if the violence intervention affects other behaviors, such as firearm use, drug use, aggre... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Violence
The Effects of Passive Heat Therapy in Patients With Chronic Kidney Disease
Recruiting
The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Renal Insufficiency, Chronic
Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases
Recruiting
This is a single arm phase 2 trial is to evaluate the efficacy of SRS plus adagrasib for the treatment of brain metastases for patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC). A total of 30 patients will be enrolled on this study.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: University of Virginia Health System, Charlottesville, Virginia
Conditions: Non Small Cell Lung Cancer, NSCLC, KRAS G12C
Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
Recruiting
The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels. After a patient has this kind of stroke, they are often given a combination of two blood thinners to prevent it from happening again. One of these blood thinners, called clopidogrel, is less effective in some people due to differences in their DNA. Clopidogrel needs to be activated by a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Ischemic Stroke, CYP2C19 Polymorphism
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Recruiting
TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairment (cognitive and behavioral foremost, along with motor, sensory, and balance), that limits their functional independence and participation, and increases their risk for secondary medical conditions,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Traumatic Brain Injury
Optical Measurements of the Skin Surface to Infer Distinctions in Myofascial Tissue Stiffness
Recruiting
This study involves imaging the skin movements of surface tissue on the back. A clinician will perform assessment and intervention procedures manually, using manual and light movements of stretch and compression.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/26/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Tissue Pain
Oral Health In Cirrhosis of the Liver (ORACLE)
Recruiting
The goal of this observational study is to learn about dental evaluation and periodontal cleaning along with scheduled follow -up on the dental health and overall health of patients with cirrhosis and also to determine what barrier(s) if any exist to improve oral health in this population.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/26/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, Virginia +1 locations
Conditions: Cirrhosis, Periodontal Diseases