Phase I/II Study of SLAMF7 FPBMC/CS-1 FPBMC in Relapsed/Refractory Multiple Myeloma
Recruiting
The purpose of this study is to understand the safety and estimate the efficacy of combining anti-CD3 x anti-SLAMF7 bispecific antibody fresh peripheral blood mononuclear cells (SLAMF7 FPBMC/CS1 FPBMC) for patients with relapsed and/or refractory multiple myeloma. Patients receive 8 weekly doses and then 8 more doses every 2 weeks of SLAMF7 FPBMC by intravenous infusion.
Gender:
All
Ages:
18 years and above
Locations: Ashley Donihee, Charlottesville, Virginia
Conditions: Multiple Myeloma
Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2
Recruiting
REDHART2 is a randomized, double-blinded, placebo-controlled trial to determine the effects of Anakinra on peak aerobic exercise capacity measured with a cardiopulmonary test after 24 weeks in patients with recently decompensated systolic heart failure and increased systemic inflammation.
Gender:
All
Ages:
21 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Failure, Systolic, Inflammation
Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
Recruiting
Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.
Gender:
All
Ages:
21 years and above
Locations: University of Virginia, Charlottesville, Virginia +1 locations
Conditions: Heart Failure
Impact of Early ADL Participation on Outcomes Post DRF
Recruiting
This study is a randomized controlled trial (RCT). This RCT which will study the effect of performing daily activities early after a distal radius fracture being treated conservatively in a cast. This study will have two groups. The experimental group will watch a video and be given a handout on how to perform daily activities with the hand of the injured wrist while in a cast and cast care. The control group will watch a video on cast care and be given a handout on cast care. Outcome measures w... Read More
Gender:
All
Ages:
18 years and above
Locations: Medical Facilities Associates, Washington, Virginia
Conditions: Distal Radius Fracture
Pediatric POTS: Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
Recruiting
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.
Gender:
Female
Ages:
Between 12 years and 18 years
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Postural Tachycardia Syndrome
Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above
Recruiting
This is a multi-center, open-label phase II study to assess the efficacy of a novel fitness-adapted regimen in previously untreated older patients with classical Hodgkin lymphoma. All participants will receive up to a total of 8 cycles of pembrolizumab (Q6 week dosing). The first cycle of pembrolizumab will be administered in combination with brentuximab vedotin (BV) ("lead-in treatment"). Following lead-in treatment, all participants will undergo interim PET/CT (iPET) as well as fitness testin... Read More
Gender:
All
Ages:
60 years and above
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Classical Hodgkin Lymphoma
Early Detection of Breast Cancer in Women With Suspicious Mammograms
Recruiting
This is a non-treatment study. It will not involve the use of any investigational drug or device. Potential participants will be enrolled through direct contact with collaborating clinical sites when the patient's annual 3D mammogram report yields a BIRADS rating of 4-5. The clinical Investigators or a member of their staff will conduct consent discussion once a suspicious mammogram report is identified or if a patient is referred for imaging of a suspicious area in the breast. After consenting... Read More
Gender:
Female
Ages:
18 years and above
Locations: Dorothy G Hoefer Comprehensive Breast Center, Newport News, Virginia +1 locations
Conditions: Breast Cancer
Comprehensive Tobacco Cessation for Cancer Patients and Survivors
Recruiting
The purpose of this research study is to learn how best to incorporate tobacco cessation treatment into clinical care for cancer patients, survivors, and caregivers.
Gender:
All
Ages:
18 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Tobacco Use Cessation, Cancer
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
Recruiting
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on CV outcomes and safety in subjects with end stage kidney disease (ESKD) undergoing maintenance dialysis with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes.
Gender:
All
Ages:
18 years and above
Locations: Peninsula Kidney Associates, Hampton, Virginia
Conditions: Atherosclerotic Cardiovascular Disease, End Stage Kidney Disease
The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment
Recruiting
The purpose of this research study is to find out about ethanol-containing e-cigarettes impact ethanol breath tests, field sobriety tests, or other tests of sobriety. Ethanol is a common part of e-cigarette liquids.
Gender:
All
Ages:
Between 21 years and 55 years
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Electronic Cigarette Use
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
Recruiting
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education condition on sleep and cognition. Internet-based recr... Read More
Gender:
All
Ages:
65 years and above
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders, Sleep Disorders, Intrinsic, Dyssomnias, Sleep Wake Disorders, Nervous System Diseases, Alzheimer Disease
Mobile Stress Management Program for African American Women
Recruiting
The unjust social, economic, and environmental conditions that African Americans face throughout their lives lead to pervasive health disparities. These disparities are driven by healthcare differences. They are driven by economic differences. Those with less financial wealth have poorer health as compared to those with higher socioeconomic status. And yet, even when controlling for these two important social determinants of health, race still predicts morbidity and mortality. What can account... Read More
Gender:
Female
Ages:
18 years and above
Locations: ISA Associates, Alexandria, Virginia
Conditions: Psychological Stress