A Guide to Esophageal Cancer Clinical Trials

Esophageal cancer is a type of cancer that occurs healthy cells start to grow and divide uncontrollably creating growths (known as tumors) along the surface of the esophagus. Doctors diagnose esophageal cancer using a camera-guided scope (endoscopy) to explore the esophagus and look for any abnormalities such as nodules or areas of irritation. If the doctor found any signs of cancer during an endoscopy they may order a biopsy to collect a sample of the abnormal growth. These tissues are analyzed for any potential cancer cells.

There are two main types of esophageal cancer: squamous cell carcinoma and adenocarcinoma.

Squamous cell carcinomas develop from normal squamous cells that run along the surface of the esophagus. On the other hand, adenocarcinomas are formed from gland cells present in the lower third of the esophagus, and it is believed to be caused mainly by the continuous exposure to stomach acid.

Early stage esophageal cancer usually doesn’t have any symptoms, however, as the cancer progresses it starts to cause the following problems and discomforts:

The causes of esophageal cancer are still not fully understood. However, doctors believe that there are a few risk factors that appear to increase a person’s risk for developing this kind of cancer.

Unfortunately, because esophageal cancer is rarely diagnosed early it has one the lowest survival rates. For that reason, doctors and researchers are constantly looking for better screening and diagnostic methods as well as more effective treatments. In order to test new approaches, researchers design clinical trials that involve esophageal cancer patients.

The main goal of a clinical trial is to assess if a new drug or intervention is safe, effective, and altogether a better alternative than available options. Clinical trials are very carefully evaluated by internal and external agencies to ensure that the health and safety of volunteers are never compromised.

To participate in a clinical trial, participants are asked to sign an informed consent document. This document outlines all the potential benefits and risks that may arise from the trial, as well as an explanation of the experimental treatment, and what will be expected from the volunteer (i.e., number of visits to the clinic or hospital, any in-patient stays, etc.) Most clinical trials also have inclusion and exclusion criteria that outline who can and cannot participate in the study and why.

If you are interested in participating in an esophageal cancer clinical trial your doctor will be able to tell you if you are a good candidate for one and may help you find a trial in your local area. Clinical trials are conducted by research centers, hospitals, and universities all across the country and many of them are always recruiting new volunteers.