Kentucky Clinical Trials

A listing of Kentucky clinical trials actively recruiting patient volunteers.

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1034 trials found

A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)


This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).

Conditions: Macular Edema, Retinal Vein Occlusion

Five Factor Model Treatment for Borderline Personality Disorder


The primary purpose of this study is to explore acceptability, feasibility, and preliminary efficacy of a novel cognitive-behavioral treatment for borderline personality disorder (BPD). Extant treatments for this condition are intensive, long-term (usually at least one year), and have, understandably, focused on targeting the life-threatening and therapy-interrupting behaviors that often characterize this disorder. BPD, however, is a heterogeneous disorder with diagnostic criteria that can be co ...

Conditions: Borderline Personality Disorder
Phase: Not Applicable

Healthy Recovery After Trauma Study


Mental contamination-an internal experience of dirtiness evoked in the absence of physical contact with an external source-has been linked to the development and maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et al., 2014; Badour et al., 2013; Brake et al., 2017). Mental contamination has been associated with greater PTSD severity (Rachman et al., 2015) and higher elevations in specific PTSD symptom clusters (particularly those of intrusi ...

Conditions: Stress Disorders, Post-Traumatic, Shame, Guilt, Sexual Assault and Rape
Phase: Not Applicable

Modulating Neuropathic Pain With Transcranial Direct Current Stimulation


This study will examine whether a form of non-invasive brain stimulation can help reduce pain in people with persistent neuropathic pain.

Conditions: Pain, Neuropathic, Complex Regional Pain Syndromes, Phantom Limb Pain, Spinal Cord Injuries
Phase: Not Applicable

A Study of Cytisinicline for Smoking Cessation in Adult Smokers


This placebo-controlled Phase 3 study is being conducted at sites within the United States to evaluate 3 mg cytisinicline TID for treatment duration of 42 days/6 weeks as well as repeating that duration for a total of 84 days/12 weeks treatment.

Conditions: Smoking Cessation

Peripheral Nerve Stimulation to Improve Upper Extremity Function After Severe Stroke


Subjects will receive non-invasive stimulation of nerves on their arm and intensive motor training of their arm. The timing of the stimulation in relation to the training will vary by group.

Conditions: Stroke
Phase: Not Applicable

Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Severe Post-stroke Hemiparesis


Individuals who experienced a stroke over one year ago will be randomly assigned to receive 1 of 4 different conditions of brain stimulation. All individuals will receive therapy of the hand and arm following the stimulation. This study will try to determine which brain stimulation condition leads to the greatest improvement in hand and arm function.

Conditions: Stroke, Hemiparesis
Phase: Not Applicable

A Registry Study of Serologic and Virologic Testing to Accelerate Recovery and Transition


The co-primary objectives of this study are to: Determine and compare the COVID-19 antibody positivity rate in health care workers and patients without a known COVID-19 infection Determine if PCR negativity for COVID-19 early in quarantine predicts negativity at Day 14 in quarantining individuals

Conditions: Covid19, SARS-CoV Infection

Testing an Online Insomnia Intervention


The objective of this trial is to determine the effectiveness of an electronic cognitive behavioral therapy for insomnia (e-CBT-I) module in improving sleep and reducing alcohol use among heavy drinkers with insomnia. Specifically, it will test the effectiveness of Sleep Healthy Using the Internet (SHUTi), a well-validated version of e-CBT-I comprised of 6 weekly educational modules and daily sleep diaries. The rationale for this mixed methods proposal is that effective, nonpharmacologic treatme ...

Conditions: Alcohol Use Disorder, Insomnia
Phase: Not Applicable

The Maintenance Effect of Enstilar Foam in Combination With Otezla


This is a single-center, open-label study. Approximately 30 qualified subjects will be enrolled in a study lasting 20 weeks which investigates the effect of Enstilar used in combination with Otezla to treat psoriasis.

Conditions: Psoriasis

The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery


The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.

Conditions: Endometriosis, Endometriosis-related Pain

Blood Flow Restriction Training, Aspiration, and Intraarticular Normal Saline


This research study is designed to allow health care professionals and researchers to answer many questions about whether either an injection of saline (salt water) in the knee or a new type of physical therapy called blood flow restriction training (called BFRT) will improve recovery after patellar dislocation.

Conditions: Patellar Dislocation, Knee Injuries, Leg Injury, Wounds and Injuries