Michigan Clinical Trials

A listing of Michigan clinical trials actively recruiting patient volunteers.

Making the decision to participate in a clinical trial is a very personal one. Some individuals do it because they have run out of options and want to try a new experimental treatment in the hope it might help their condition, while others do it because they want to do their part helping the clinical community move forward and potentially help cure many people down the line. For individuals looking to participate, there are a wide array of clinical trials in Michigan looking for participants who can commit to seeing the trials through. The biggest city of Michigan is Detroit, “The Motor City” that was central to America’s auto industry for decades. Lansing is the capital, while Ann Arbor and Grand Rapids round out the list with some of the most beautiful views of any urban area in America. Michigan boasts the longest freshwater coastline of any U.S. state, adding to its reputation for outdoor recreation. Today’s Michigan is increasingly building businesses in professional services, health, and education. Medical care has kept up with the times, with the University of Michigan Hospitals and Health Centers blazing the trail toward world class community health.

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2155 trials found

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

NCT04706533

To better understand the role of inflammation in COVID-19, we established the Michigan Medicine COVID-19 Cohort (M2C2). M2C2 is a funded and ongoing cohort which has currently enrolled over 1500 adult patients (≥18 years) with severe COVID-19 admitted at the University of Michigan. The purpose of M2C2 is to define the in-hospital course of these patients and understand the role of inflammation as a determinant of organ injury and outcomes in COVID-19.

Conditions: Covid19, Kidney Diseases, Inflammation, SARS-CoV Infection

Novel Decision Aid for Carpal Tunnel Patients

NCT04693273

A questionnaire will be given to patients who are considering undergoing hand surgery as a treatment for Carpal Tunnel Syndrome to help participants decide between two surgical options- Wide-Awake-Local-Anesthesia-no-Tourniquet (WALANT) and traditional open hand surgery. These patients will be asked to complete a pre-questionnaire knowledge test and a post-questionnaire knowledge test. the primary objective is to validate this questionnaire to be used by other orthopedic surgeons. This study wil ...

Conditions: Carpal Tunnel Syndrome

A Study of PY314 in Subjects With Advanced Solid Tumors

NCT04691375

A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY314 as a Single Agent and In Combination with Pembrolizumab in Subjects with Advanced Solid Tumors

Conditions: Advanced Solid Tumor

FastThread Interference Screws

NCT04689061

Surgery using the Arthrex PEEK or Biocomposite FastThread Interference Screw for ACL or PCL (PCL at US sites only, Biocomposite screw PCL only) repair or reconstruction.

Conditions: ACL Injury
Phase: Not Applicable

Eptinezumab in Patients With Episodic Cluster Headache

NCT04688775

The purpose of this study is to evaluate the efficacy of eptinezumab in patients with episodic Cluster Headache (eCH)

Conditions: Cluster Headache, Episodic

Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities

NCT04683250

Phase 1 and 2 trial to study the safety, pharmacokinetics, and efficacy of TAS0953/HM06 in patients with advanced solid tumors with RET gene abnormalities. Phase 1 aims to determine the Maximum Tolerated Dose (MTD) and identify the Recommended Phase 2 Dose (RP2D) to be used in phase 2.

Conditions: RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors
Phase: Phase 1/2

Using Cannabidiol to Treat Diabetic Peripheral Neuropathy of the Feet

NCT04679545

The purpose of the study is to evaluate whether PG-DN-20WS is a better pain reliever in patients with diabetic neuropathic pain of the feet than a placebo.

Conditions: Diabetic Peripheral Neuropathic Pain

BRITEPath- Phase 2

NCT04672798

BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation. BRITEPath utilizes BRITE, a safety planning and emotion regulation app that is loaded on the patient's smart phone and has previously been shown to be well accepted and to reduce suicide attempts compared to usual care in psychiatric inpatients (HR = 0.49). To support me ...

Conditions: Depression, Suicidal Ideation
Phase: Not Applicable

Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies

NCT04672434

The primary purpose of this study is to see if Sym024 is safe and tolerable as monotherapy and in combination with Sym021 in patients with solid tumor malignancies.

Conditions: Metastatic Cancer, Solid Tumor

Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm

NCT04671082

This is a double-blind, randomized, placebo-controlled, multicenter study of the efficacy and safety of tolperisone (a non-opioid) or placebo administered in subjects with pain due to acute back muscle spasm.

Conditions: Back Muscle Spasm, Back Pain, Back Strain, Back Spasm Upper, Muscle Spasm, Acute Pain

Study of JTX 8064, as Monotherapy and in Combination With a PD-1 Inhibitor, in Adult Subjects With Advanced Refractory Solid Tumors

NCT04669899

JTX-8064-101 is a Phase 1, open label, dose escalation clinical study to determine the safety, tolerability, and recommended Phase 2 dose of JTX-8064 alone and in combination with either JTX-4014 or pembrolizumab.

Conditions: Cancer

LYT-200 Alone and in Combination With Chemotherapy or Anti-PD-1 in Patients With Metastatic Solid Tumors

NCT04666688

A Phase 1/2 Open-label, Multi-center Study of the Safety, Pharmacokinetics, and Anti-tumor Activity of LYT-200 Alone and in Combination with Chemotherapy or Anti-PD-1 in Patients with Metastatic Solid Tumors

Conditions: Metastatic Cancer, Solid Tumor, Cholangiocarcinoma, Colorectal Cancer, Pancreatic Cancer
Phase: Phase 1/2

Clinical trials vary in time; in total a single clinical trial may take up to 15 years to complete, and some longitudinal studies ask the participant to stay in touch for follow up questions for a few years after their participation in the study is finished. Depending on the goal and the design of a clinical trial, volunteers may be asked to stay on site for a set amount of nights; this happens because the researchers might want to monitor the participant’s at different hours of the day or night. Some clinical research is also setup to compensate individuals, and paid clinical trials are not uncommon.

In Michigan, the University of Michigan division of research has one of the largest clinical trial and research centers in the state, where interested volunteers can enroll in studies for healthy or non-healthy individuals. The Barbara Ann Karmanos cancer institute in Detroit, Michigan also offers clinical trials for many types of cancers for both healthy and non-healthy individuals.

Volunteers who decide to participate in a clinical trial may be compensated for their time and travel expenses during their participation in the study. The compensation will vary depending on the type of study and level of participation required from the volunteer, but paid clinical trials in Michigan are very common.

Participating in a clinical trial is always completely voluntary. This means that nobody, regardless of their condition can be forced to participate nor can they be forced to continue participating in a trial if they wish to withdraw from the study. Non-healthy individuals who decide to enroll in a clinical trial after a suggestion from their doctor or to try an experimental treatment for their condition will never be denied care if they decide to drop out of the study.