A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
Recruiting
The purpose of this study is to identify the recommended Phase 2 (combination) dose (RP2CD) of the amivantamab and cetrelimab combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection); and to evaluate the antitumor effect of the combination at the selected RP2CD in participants with NSCLC characterized by epidermal growth factor receptor (EGFR) exon19del or exon 21 leucine 858 to arginine substitution (L858R) mutations, who have progresse... Read More
Gender:
All
Ages:
18 years and above
Locations: Virginia Cancer Specialists, Fairfax, Virginia +3 locations
Conditions: Carcinoma, Non-Small-Cell Lung
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
Recruiting
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability among African American menthol smokers.
Gender:
All
Ages:
21 years and above
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Electronic Nicotine Delivery System Flavors
Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products
Recruiting
This study will investigate the effects of narratives on demand for low and high ventilated cigarettes and substitution for alternative products in the Experimental Tobacco Marketplace.
Gender:
All
Ages:
21 years and above
Locations: Addiction recovery Research center, Roanoke, Virginia
Conditions: Cigarette Smoking
The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain
Recruiting
Patients are already receiving an intravitreal injection as a standard of care, but they are consenting to receiving a loteprednol drop following the intravitreal injection. This clinical trial is studying the role of loteprednol (corticosteroid) in reducing pain following intravitreal injections for patients with age-related macular degeneration. As of now, there is no definitive pain management technique following intravitreal injections. Loteprednol is a corticosteroid widely used in ophthalm... Read More
Gender:
All
Ages:
18 years and above
Locations: Vistar Eye Center, Roanoke, Virginia
Conditions: Age-Related Macular Degeneration
NEXUS - Next Generation Health Through 2D & 3D Fetal UltraSound; Building Connections to Support Maternal-fetal Health
Recruiting
This exploratory study brings together an interprofessional team, novel tools, and innovative, community-driven care delivery approaches to improve health equity among mother-infant dyads impacted by substance use disorder and high risk for poor health outcomes. This study will test a community-informed and community-based intervention using a fetal ultrasound protocol, motivational interviewing techniques, strength-based education, and healthcare coordination strategies to reduce health dispari... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Pregnancy Related, Substance Use, Mental Health Issue
Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)
Recruiting
This is a randomized, double-blind, placebo-controlled trial to determine the optimal dose and safety of oral alanyl-glutamine between 4, 24, and 44 g doses administered for 10 days with standard therapy among first time incident cases of uncomplicated C. difficile infection (CDI) in hospitalized persons aged 65 or older. Our hypothesis is that alanyl-glutamine supplementation will decrease recurrence and mortality from CDI and these outcomes will be associated with improvement of inflammatory m... Read More
Gender:
All
Ages:
Between 18 years and 105 years
Locations: UVA Health Systems, Charlottesville, Virginia
Conditions: Clostridioides Difficile Infection, Clostridium Difficile Infection, Clostridium Difficile Diarrhea, Clostridia Difficile Colitis
89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
Recruiting
A prospective, open-label, phase 2 study to explore CAIX expression through 89Zirconium-labelled girentuximab deferoxamine (89Zr-girentuximab) PET/CT imaging in patients with solid tumors.
Gender:
All
Ages:
Between 18 years and 95 years
Locations: Carilion Clinic, Roanoke, Virginia +1 locations
Conditions: Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Glioblastoma Multiforme, Cholangiocarcinoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Non Small Cell Lung Cancer, Small Cell Lung Cancer, Epithelial Ovarian Cancer, Pancreatic Ductal Adenocarcinoma, Soft Tissue Sarcoma
Workplace Fall Prevention Through Slip Recovery Training
Recruiting
The goal of this clinical trial is to evaluate the feasibility of applying slip recovery training, a novel balance training exercise intervention, to workers who are at increased risk of slip-induced falls. This will be done via field studies with industrial partners. The main specific aims are are: To investigate the feasibility of on-site slip recovery training To validate field assessments for evaluating slip recovery training efficacy in subsequent research Participants will complete 3-6... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Locations: Virginia Tech, Blacksburg, Virginia
Conditions: Accidental Fall
The FBRI VTC Neuromotor Research Clinic
Recruiting
The FBRI VTC Neuromotor Research Clinic was established and opened in May of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. It is direct by Dr. Stephanie DeLuca and based on the principles surrounding ACQUIREc Therapy. ACQUIREc Therapy is an evidenced-based approach to pediatric constraint-induced movement therapy, which refers to a multi-component form of therapy that is focused on helping children who have asymmetric moto... Read More
Gender:
All
Ages:
Between 3 months and 18 years
Locations: Fralin Biomedical Research Institute - VTC, Roanoke, Virginia +1 locations
Conditions: Neuromotor Impairments, Cerebral Palsy, Microcephaly, Autism, Trauma, Brain, Acquired Brain Injury, Pediatric Stroke
Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing
Recruiting
This is a twelve-week single-center, randomized, double-blind, clinical study to evaluate the safety and efficacy of a folic acid wound treatment (FAWT) versus Placebo in the promotion of healing of chronic, early stage diabetic foot ulcer (ES-DFU) wounds. Male and female Veterans with type-2 diabetes mellitus and chronic ES-DFUs acceptable to the study inclusion/exclusion criteria will be considered for enrollment.
Gender:
All
Ages:
18 years and above
Locations: Hunter Holmes McGuire VAMC, Richmond, Virginia
Conditions: Diabetic Foot Ulcer
Highly Processed Foods and Vascular Health
Recruiting
Age is the primary risk factor for cardiovascular disease (CVD) and age-related vascular dysfunction is considered the key process linking the two. Middle age is a particularly vulnerable period when risk factors exceed diagnostic thresholds and clinical expression of CVD first becomes evident. Ultra-processed foods (UPF) comprise almost 60% of total energy in the standard American diet. The results of observational studies suggest that UPF consumption increases CVD risk, independent of overall... Read More
Gender:
All
Ages:
Between 45 years and 65 years
Locations: Virginia Polytechnic and State University, Blacksburg, Virginia
Conditions: Cardiovascular Diseases
The Group Risk Reduction Intervention Therapy (GRRIT) Project
Recruiting
Investigators will evaluate a group format adaptation of Brief Cognitive-Behavioral Therapy for Suicide (i.e., G-BCBT) on suicide ideation (Aim 1), ability to use coping strategies (Aim 2), and overall mental health (exploratory analysis). The combination of tailored means safety counseling and training in evidence-based emotion regulation and cognitive flexibility skills delivered via a 12-session group therapy treatment will decrease service members' overall suicide risk. The group format will... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Locations: Naval Medical Center Portsmouth, Portsmouth, Virginia
Conditions: Suicidal Ideation, Suicide, Attempted, Coping Skills, Depression, Anxiety, PTSD