Maryland Clinical Trials

A listing of Maryland clinical trials actively recruiting patient volunteers.

With its alluring harbor district, Baltimore is the capital and most visited city in Maryland, a convenient place to stay if you’re taking a trip into Washington DC. Annapolis, Ocean City, and Bethesda offer lots to do. Maryland was the original birthplace of the national anthem and is known today for the blue crabs that come from Chesapeake Bay. Maryland has one of the strongest healthcare networks in the country. Of its many great healthcare providers, Johns Hopkins Hospital stands out. It is one of America’s leading centers of medical research, the teaching hospital of Johns Hopkins School of Medicine.

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2821 trials found

Relative Bioavailability Study and Food Effect Study of TT-00420 Capsule and Tablet Formulations in Healthy Volunteers

NCT04705922

This study is an open-label, 3-way crossover randomized study in adult healthy volunteers to evaluate the relative bioavailability of TT-00420 tablet and capsule formulations and to evaluate food effect on the pharmacokinetics of TT-00420 tablet.

Conditions: Healthy

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

NCT04702243

The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia (PCD).

Conditions: Primary Ciliary Dyskinesia, Primary Immune Deficiency, Kartagener Syndrome

Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response

NCT04692662

Background: People with advanced cancer are usually treated with surgery, radiation, immunotherapy drugs, or chemotherapy drugs. Talazoparib is a type of drug called a PARP inhibitor. It prevents DNA repair and has shown anticancer activity in early clinical trials. Researchers want to learn more about how it works in different types of patients. Objective: To find out how talazoparib works in tumor cells and if it works differently in people who have or have not already been treated with ano ...

Conditions: Solid Tumors

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

NCT04694131

Background: Transcranial magnetic stimulation (TMS) of the brain has been used to change the activity and connections in the brain to improve memory. Researchers are interested in how these brain changes cause memory improvements and how activity at the time of stimulation may change the effects of TMS. Objective: To learn how brain stimulation can be used to improve memory. Eligibility: Healthy adults ages 18-40 Design: Participants will be screened with a medical record review. Partic ...

Conditions: Normal Physiology
Phase: Not Applicable

Efficacy Trial of the CALM Intervention

NCT04693858

Excessive anxiety among elementary students is highly prevalent and associated with impairment in academic, social, and behavioral functioning. The primary aim of this project is to evaluate the initial efficacy of a brief nurse-delivered intervention (CALM: Child Anxiety Learning Modules), relative to a credible comparison (CALM-R, relaxation skills only) and a waitlist control for reducing anxiety symptoms and improving education outcomes at post intervention and at a 1-year follow-up. In addi ...

Conditions: Anxiety Disorder of Childhood
Phase: Not Applicable

Natural History of Coronavirus Disease (COVID-19) in Systemic Autoimmune Diseases

NCT04690816

Background: Viral infections such as COVID-19 may lead to flare-ups in people with systemic autoimmune diseases (SAD). These infections may also change the function of their immune system and/or cause problems with their blood vessels. Researchers want to learn how people with SAD respond to treatments or vaccines for COVID-19. Objective: To understand how COVID-19 affects inflammation, the immune system, and blood vessels in adults and children with autoimmune diseases. Eligibility: People ...

Conditions: Systemic Autoimmune Diseases

Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts

NCT04691622

This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or with primary immunodeficiency disorders (PID) who have not undergone HSCT.

Conditions: Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT), Primary Immunodeficiency Disorders (PID)

An Exploratory Study of PQ Grass 27600 SU

NCT04687059

PQGrass309 is aimed at exploring the expected average treatment effect of PQ Grass 27600 SU cumulative dose on symptom and medication score in a field setting. The study will enrol adult subjects with seasonal allergic rhinitis and/or rhinoconjunctivitis (SAR) induced by grass pollen exposure.

Conditions: Rhinitis, Allergic, Seasonal
Phase: Phase 2/3

Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care

NCT04685304

Pharmacogenomics (PGx) Applied to Chronic pain Treatment in primary care (PGx-ACT) is an open-label, prospective, randomized trial. Participants prescribed a relevant opioid and meet additional eligibility criteria will be randomized into either a PGx-guided care (intervention) arm or standard care (control) arm. The investigators will test the hypothesis that patients with intermediate or poor CYP2D6 metabolism assigned to PGx-guided care arm will experience improved pain control at 3 months co ...

Conditions: Chronic Pain
Phase: Not Applicable

Risk Stratification of COVID-19 Using Urine Biomarkers

NCT04681040

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in infected patients, it produces symptoms which range from completely asymptomatic to those expressing severe illness. Early recognition of those developing severe manifestations allows for rapid and appropriate intervention, including admission to intensive care unit and intensive care therapy, such as mechanical ventilation. A current problem is that only limited data exist predic ...

Conditions: Covid19, Urine, Biomarker, Acute Respiratory Failure With Hypoxia

Assessment of Self-Collected Sample Compared to Clinician Collected Sample in COVID-19 and Influenza Program

NCT04681950

We are trying to see whether a self-collected saliva swab in the home setting is as good as or better than a study clinician-collected anterior nose swab in evaluating whether you are positive for COVID-19 or Influenza A/Influenza B. You may have no symptoms, so you may be positive and capable of spreading the infection to others and you don't know it. Knowing whether you are positive is important because you would have to quarantine and not go out to prevent spreading the infection to others.

Conditions: Subjects Possibly Exposed to COVID-19

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

NCT04669665

The purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major Depressive Disorder (MDD) and suicidality, in participants who are assessed to be at imminent risk for suicide, as measured by the change from baseline on the Montgomery-Asberg Depression Rating Scale (MADRS) total score at 24 hours post first dose.

Conditions: Depressive Disorder, Major, Suicidal