North Carolina is currently home to 2743 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Winston-Salem, Charlotte and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease
Recruiting
LASN01 is a novel, fully human antibody directed against the human IL-11 receptor being developed for treatment of patients with thyroid eye disease (TED). The primary and secondary objectives of this study are to evaluate the safety, efficacy, and pharmacokinetics of 2 dose levels of LASN01 administered IV in patients with TED.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Site 110, Wilmington, North Carolina
Conditions: Thyroid Eye Disease, Eye Diseases, Graves Ophthalmopathy, Graves Orbitopathy, Thyroid Associated Ophthalmopathy, Endocrine System Diseases, Orbital Diseases, Proptosis
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Recruiting
The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 [NCT05620823] or INCB 54707-302 [NCT05620836]).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Investigative Site US205, Chapel Hill, North Carolina
Conditions: Hidradenitis Suppurativa (HS)
Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis
Recruiting
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).
Gender:
All
Ages:
40 years and above
Trial Updated:
02/23/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Idiopathic Pulmonary Fibrosis
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
Recruiting
The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
02/23/2024
Locations: East Carolina University Brody Outpatient Center, Greenville, North Carolina
Conditions: Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Estradiol Therapy In Transgender Women to Research Interactions With HIV Therapy
Recruiting
Transgender women (TW) are a key population and priority for HIV treatment. More research is needed to develop evidence-based clinical guidance when it comes to choosing antiretroviral treatment (ART) regimens for TW on feminizing hormonal therapy (FHT). Concerns about ART interacting with FHT and decreasing its effectiveness can lead to decreased ART adherence and increased viral loads. The GET IT RiGHT trial aims to address concerns about drug-drug interactions (DDIs) between ART and FHT whil... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Chapel Hill CRS (3201), Chapel Hill, North Carolina
Conditions: HIV I Infection
Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors
Recruiting
The purpose of this study is to characterize the safety, tolerability, PK, and efficacy of INCB 99280 in combination with ipilimumab in participants with select solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: University of North Carolina At Chapel Hill, Chapel Hill, North Carolina
Conditions: Melanoma, Hepatocellular Carcinoma (HCC), Renal Cell Carcinoma (RCC), Microsatellite Instability - High (MSI-H), Mismatch Repair Deficient (dMMR), Colorectal Carcinoma (CRC)
XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)
Recruiting
The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Duke University, Durham, North Carolina
Conditions: Heart Failure, Transplant; Failure, Heart
A Study of CC-97540 in Participants With Severe, Refractory Systemic Lupus Erythematosus (SLE)
Recruiting
The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory Systemic Lupus Erythematosus (SLE).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Lupus Erythematosus, Systemic
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Recruiting
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/23/2024
Locations: Onsite Clinical Solutions, Llc Charlotte Central Office, Charlotte, North Carolina
Conditions: Moderate to Severe Asthma
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Recruiting
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both. CD may be associated with abdominal cramps/pain, diarrhea, blood in the stool, weight loss, or delayed growth in children. While the exact cause of CD is not certain it is thought that the immune system located in the intestine reacts abnormally to the large number of bacteria contained there. The investigators think that diet, exposure to anti... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
02/23/2024
Locations: Levine Children's, Charlotte, North Carolina
Conditions: Crohn Disease
Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pneumonia
Recruiting
This is a placebo-controlled study to evaluate the addition of CAL02 to standard of care in treating hospitalized subjects diagnosed with severe community acquired bacterial pneumonia (SCABP) requiring critical care measures
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Wake Forest Baptist Health Hospital, Winston-Salem, North Carolina
Conditions: Pneumonia, Bacterial
Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis
Recruiting
The primary objective of this study is to evaluate the safety and tolerability of oral daily administration of TTI-101 over a 12-week treatment duration in participants with idiopathic pulmonary fibrosis (IPF).
Gender:
All
Ages:
40 years and above
Trial Updated:
02/23/2024
Locations: Pulmonix, Greensboro, North Carolina
Conditions: Idiopathic Pulmonary Fibrosis