Texas Clinical Trials

A listing of Texas clinical trials actively recruiting patient volunteers.

With over 100,000 clinical trials happening every year in United States, there are always many clinical trials going on in every state, including Texas. Hospitals, universities, pharmaceutical companies, and research organizations conduct clinical trials, and while some of them require a stay at the facilities, others just require daily or weekly visits from the volunteers.

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4466 trials found

Effect of Diet on the Immune System in Patients With Stage III-IV Melanoma Receiving Immunotherapy, DIET Study

NCT04645680

This phase II trial investigates the possible immune effects of two different diets targeting the gut microbiome in patients with stage III-IV melanoma that has been removed by surgery (resectable), has spread to other places in the body (metastatic), or is unable to be removed by surgery (unresectable), and who are being treated with the immunotherapy drugs pembrolizumab or nivolumab as part of their standard of care. Both diets are whole foods diets that meet the American Cancer Society recomm ...

Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Melanoma, Pathologic Stage III Cutaneous Melanoma AJCC v8, Pathologic Stage IV Cutaneous Melanoma AJCC v8, Unresectable Melanoma

Evaluation of the Safety and Effectiveness of the Dexcom Glucose Monitoring (CGM) System

NCT04645641

Evaluation of the Safety and Effectiveness of the Dexcom Glucose Monitoring (CGM) System

Conditions: Diabetes Mellitus
Phase: Not Applicable

A Placebo Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19

NCT04646044

The main purpose of this phase-1b, multicenter, randomized double-blind, placebo-controlled, trial is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of bempegaldesleukin (BEMPEG; NKTR-214) in combination with standard of care (SOC) in adult patients with mild COVID-19 (coronavirus disease 2019). The trial will also define the recommended phase 2 dose (RP2D) of bempegaldesleukin in patients with mild COVID-19.

Conditions: Covid-19, Coronavirus Disease 2019

Parent and Family Oriented Support Interventions for the Facilitation of Weight Loss in African American Families

NCT04644224

This study tests the effectiveness of parent and family oriented support interventions that are designed to help with weight loss among African American families. Obesity tends to run in families, thus family based interventions, with parents as main change agents have been strongly recommended. The parent and family oriented support Interventions may help facilitate weight loss among African American families.

Conditions: Obesity-Related Malignant Neoplasm
Phase: Not Applicable

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

NCT04644068

This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.

A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration

NCT04643886

This study is designed to investigate the safety, PK/PD, biomarker and early clinical effects of repeat GEM103 IVT injections.

Conditions: Dry Age-related Macular Degeneration, Geographic Atrophy, Macular Degeneration, Retinal Disease, Retinal Degeneration

Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

NCT04643795

The purpose of this study is to directly characterize the pharmacokinetic (PK) profiles of MGL-3196 and its major metabolite (MGL-3623) following administration of multiple oral doses (QD x 6 days) in subjects with varying degrees of hepatic impairment (HI) compared to healthy matched control subjects with normal hepatic function, including a subset of NASH subjects.

Conditions: Hepatic Impairment, NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Liver

The Rise in Robotic Atypical Segmentectomies

NCT04644952

This study investigates the increased rate of robotic atypical segmentectomies. Segmentectomy refers to removing a section of a lobe of the lung. Reviewing patients' data retrospectively may help researchers determine whether robotic surgery has led to an increase in atypical segmentectomy.

Conditions: Lung Carcinoma

Sym021 in Combination With Either Sym022 or Sym023 in Patients With Advanced Solid Tumor Malignancies

NCT04641871

This study will evaluate the preliminary efficacy of the 2 combinations (Sym021+Sym022 and Sym021+Sym023) in each tumor type under study by assessing ORRs per Investigator assessment using Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1. This study will also evaluate the safety and tolerability profile of the 2 combinations (Sym021+Sym022 and Sym021+Sym023)

Conditions: Metastatic Cancer, Solid Tumor

A Multi-Center, Open Label, Extension Study Assessing the Efficacy and Safety of Additional Intravitreal Injections of RBM-007 in Subjects With Wet Age-related Macular Degeneration

NCT04640272

This is a multi-center, open label, extension study of NCT04200248 assessing the efficacy and safety of additional intravitreal injections of RBM-007 in subjects with wet age-related macular degeneration.

Conditions: Exudative Age-related Macular Degeneration

Peroral Endoscopic Myotomy for the Treatment of Achalasia

NCT04640753

There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 & a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021

Conditions: Achalasia

Obesity in G60 Trauma Patients

NCT04640701

Obesity is a national epidemic that affects all aspects of health care, including trauma care. According to the Centers for Disease Control and Prevention, 1% of US adults 20 years old and older are obese (body mass index [BMI], calculated as weight in kilograms divided by height in meters squared, > 30), and 69% are overweight (BMI > 25) (1, 2). Obesity is a major health concern because of its established relationship with serious medical diseases and increased likelihood of comorbid conditions ...

Conditions: Obesity

A clinical trial is conducted when a researcher finds a potential new drug, medical device, surgical procedure or intervention that has the potential of improving the lives of many but still needs to be tested to see if it is effective and safe for humans. In the state of Texas, there are a number of paid clinical trials for willing participants.

Clinical trials can last for many years because the medication or the intervention needs to be tested on many participants to ensure its safety and effectiveness. Many hospitals such as the Houston Methodist Hospital in Houston, Texas conduct clinical trials especially to find new treatments for diseases such as cancer, heart disease, and hormonal conditions. Hospitals tend to recruit participants by informing patients of the research study inviting them to participate.

On the other hand, pharmaceutical companies that develop new medications or medical devices sometimes need to hire companies to conduct all the different stages of clinical trials for them. These companies are called contract research organizations or CROs.

CROs provide management and support for institutions that need to conduct clinical trials but don’t have the expertise or infrastructure to do so. CROs are responsible for recruiting the participants for the study, monitoring the trials, and ensuring that all parts of the study are being conducted according to protocol.

In Texas, there are several CROs that actively recruit volunteers year-round to participate in clinical trials. Some of the major CROs in Texas include: Covance, PPD, and Clinical Trials of Texas.