Texas Clinical Trials

A listing of Texas clinical trials actively recruiting patient volunteers.

With over 100,000 clinical trials happening every year in United States, there are always many clinical trials going on in every state, including Texas. Hospitals, universities, pharmaceutical companies, and research organizations conduct clinical trials, and while some of them require a stay at the facilities, others just require daily or weekly visits from the volunteers.

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4368 trials found

Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines

NCT04595422

This implementation study will examine the best ways to refer heavy smokers to information about lung cancer screening.

Conditions: Lung Carcinoma
Phase: Not Applicable

Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma

NCT04594187

This phase III trial seeks to determine the role of nodal radiation therapy after sentinel lymph node biopsy (SLNB) for patients with high risk sentinel lymph node positive melanoma who are planned for immunotherapy without completion lymph node dissection. Patients with a positive inguinal node will be excluded due to increased risk of radiation-associated toxicity at this site. Prior studies of patients with more advanced melanoma have shown nodal radiation therapy can decrease the risk of nod ...

Conditions: Melanoma

Electroencephalographic Changes Under General Anesthesia in Patients With Gynecologic Cancers With and Without History of Chemotherapy

NCT04593550

This study compares changes in brain waves in women with gynecologic cancers who have or have not received chemotherapy and who are scheduled to receive surgery as part of their standard care. Electroencephalography is a test that measures brain waves and may help learn if sensitivity to anesthesia is higher in women who have received chemotherapy than women who have not. This study may help researchers learn if receiving chemotherapy before surgery can affect the way the brain responds to anest ...

Conditions: Malignant Female Reproductive System Neoplasm

Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants

NCT04595513

This trial will use a two stage, phase I/II clinical trial design. The first stage will employ an open-label clinical trial design to verify dosing for TAVT-18 (sirolimus) powder for oral solution in TSC infants (N=5). Results will then be carried forward to inform appropriate initial dosing, dosing frequency, and dosing adjustments for the second stage, a randomized, double-blind, placebo-controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seiz ...

Conditions: Tuberous Sclerosis Complex, Epilepsy
Phase: Phase 1/2

A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)

NCT04592419

This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).

Conditions: Macular Edema, Retinal Vein Occlusion

Financial Toxicity in Cancer Patients

NCT04592250

This study will seek to generate the early data needed to understand the relationship between constructs and measures of patients' coping resources and psychological response and measures of patients' financial toxicity. To collect this early descriptive data, the overall goal of this study is to identify social, behavioral, and knowledge factors associated with financial toxicity outcomes. Identifying these factors will ultimately help elucidate targets for behavioral, psychosocial, and/or educ ...

Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors

NCT04592484

This is a first-in-human, Phase 1/2 open-label, multicenter, dose escalation, safety, pharmacodynamic, and PK study of CDK-002 in subjects with advanced/metastatic, recurrent, injectable solid tumors, whose disease has progressed despite receiving standard of care treatment. CDK 002 will be administered intratumorally (IT). Part A will enroll subjects with advanced/metastatic, recurrent, injectable solid tumors with emphasis on head and neck squamous cell cancer (HNSCC), triple negative breast ...

Conditions: Advanced Solid Tumor
Phase: Phase 1/2

Facial and Body Motion Technology and Stroke

NCT04592627

The purpose of this study is to customize privacy protected facial expression and body motion tracking for use in the home environment by stroke survivor-informal caregiver dyads by investigating within a simulated home environment, background variability,possible occlusions, privacy considerations, and the motor weaknesses, gait impairments, and facial expressions of stroke survivors and to determine the acceptability of the customized facial expression and body motion technology in stroke surv ...

Conditions: Stroke

A Study of ALKS 4230 on the Tumor Microenvironment

NCT04592653

The primary objective of this study is to evaluate the effects of ALKS 4230 monotherapy on the tumor microenvironment of a variety of advanced, malignant solid tumors.

Conditions: Advanced Solid Tumor

Peri-device Leakage Closure After LAAO

NCT04590898

The investigators thought to evaluate the safety and feasibility of peri-device leakage closure after left atrial appendage occlusion (LAAO, either surgical or interventional) with different devices.

Conditions: Atrial Fibrillation, Stroke, Bleeding, Leakage of Cardiac Device

Penile Blood Flow Characteristics Following Caudal or Penile Block

NCT04590859

Pediatric urologic surgery is generally accompanied by use of a caudal or penile block for analgesia. A caudal block is performed by injecting local anesthetic in the low epidural space while a penile block is performed by injecting local anesthetic above the pubic symphysis. Local anesthetic in the epidural space is known to caudal vasodilation interiorly. It is unknown as to whether this vasodilation results in alteration in flow to the penile tissue and potentially changes tissue characterist ...

Conditions: The Aim of This Study is to Measure Blood Flow Before and After a Block

An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer Undergoing Radiation Therapy and/or Systemic Therapy

NCT04589624

This trial investigates whether hyperpolarized magnetic resonance imaging (hpMRI) can predict treatment response in patients with thyroid cancer undergoing radiation therapy and/or receiving systemic therapy before surgery. An hpMRI is like a standard MRI but involves the use of an imaging contrast agent called hyperpolarized 13-C-pyruvate. Diagnostic procedures, such as hpMRI, may predict a patient's response to treatment and may help plan the best treatment.

Conditions: Thyroid Gland Carcinoma
Phase: Early Phase 1

A clinical trial is conducted when a researcher finds a potential new drug, medical device, surgical procedure or intervention that has the potential of improving the lives of many but still needs to be tested to see if it is effective and safe for humans. In the state of Texas, there are a number of paid clinical trials for willing participants.

Clinical trials can last for many years because the medication or the intervention needs to be tested on many participants to ensure its safety and effectiveness. Many hospitals such as the Houston Methodist Hospital in Houston, Texas conduct clinical trials especially to find new treatments for diseases such as cancer, heart disease, and hormonal conditions. Hospitals tend to recruit participants by informing patients of the research study inviting them to participate.

On the other hand, pharmaceutical companies that develop new medications or medical devices sometimes need to hire companies to conduct all the different stages of clinical trials for them. These companies are called contract research organizations or CROs.

CROs provide management and support for institutions that need to conduct clinical trials but don’t have the expertise or infrastructure to do so. CROs are responsible for recruiting the participants for the study, monitoring the trials, and ensuring that all parts of the study are being conducted according to protocol.

In Texas, there are several CROs that actively recruit volunteers year-round to participate in clinical trials. Some of the major CROs in Texas include: Covance, PPD, and Clinical Trials of Texas.