Illinois Clinical Trials

A listing of Illinois clinical trials actively recruiting patient volunteers.

Illinois’ capital, The Windy City of Chicago, attracts millions of visitors annually to enjoy the boat tour of architectural marvels like the Rookery Building, Wrigley Building, and Tribune Tower – at the time of their establishment, some of the tallest skyscrapers in the world. Further afield, in cities like Peoria, Rockford, Elgin, and Naperville, you can enjoy classic Illinois meals including foot-long hot dogs, deep dish pizza, and pierogis. There are excellent hospitals throughout Illinois, many just minutes from major cities. Though not the largest, Northwestern Memorial Hospital has been named #1 in Chicago and among the nation’s top ten hospitals.

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2630 trials found

Tolerance and Safety of a Ketone-Promoting Food Ingredient

NCT04707989

The objective of this study is to capture information on tolerance and safety of a ketone-promoting food ingredient in healthy adults.

Conditions: Tolerance
Phase: Not Applicable

Effect of Education on Treatment Decision Making for Patients With Prostate Cancer on Chronic Hormone Treatments

NCT04705038

The purpose of this study is to learn how an educational intervention about orchiectomy as an alternative to medical castration for those who are already on medical castration will impact the number of patients willing to undergo an orchiectomy (surgery to remove the testicles).

Conditions: Prostate Cancer
Phase: Not Applicable

The Effects of Direct Context Reactivation During Sleep on Memory

NCT04702152

The context in which memories are encoded is a major factor influencing how memories are organized. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this context is later reinstated to recall the details related to the memory. Although the role of context has been explored with regard to memory encoding and retrieval, its role during sleep-related memory consolidation has not been explored. Memories are thought to be reactiva ...

Conditions: Sleep, Consolidation
Phase: Not Applicable

Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas Transplantation

NCT04690738

Pancreas transplantation is currently the most reliable method for glycemic control in insulin dependent diabetic patients. Outcomes of pancreas transplantation have improved significantly over the years due to improved surgical techniques, medical management and immunosuppression. However, weight gain after pancreas transplantation remains a common problem with associated consequences such as development of type 2 diabetes, coronary artery disease, graft loss, metabolic syndrome and increased r ...

Conditions: Exocrine Pancreatic Insufficiency, Weight Gain

The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.

NCT04691323

The primary objective of this study is to better understand factors contributing to variations in hydroxyurea (HU) adherence behavior in adolescents and young adults (AYA) with sickle cell disease (SCD). To meet this objective, the researchers will conduct a prospective cohort study to determine the longitudinal relationship between HU adherence and health-related quality of life (HRQOL) overtime among AYA with SCD. The long-term goal of this research is to promote medication adherence behavior ...

Conditions: Sickle Cell Disease, Sickle B+ Thalassemia, Sickle Beta Zero Thalassemia, Sickle Cell Hemoglobin C
Phase: Not Applicable

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Males - A Sub-study of HPTN 083

NCT04692077

This study will establish the minimum safety, tolerability and acceptability data needed to support the use of cabotegravir long-acting injection (CAB LA) in an adolescent population, potentially transforming the field of HIV prevention for young people.

Conditions: HIV Infections

A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)

NCT04688164

This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.

Conditions: Major Depressive Disorder

Cardiogenic Shock Working Group Registry

NCT04682483

The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes.

Conditions: Cardiogenic Shock

Efficacy and Safety of Belumosudil in Subjects With Diffuse Cutaneous Systemic Sclerosis

NCT04680975

This is a phase 2, open-label, single-cohort, multicenter trial of belumosudil in subjects with Diffuse Cutaneous Systemic Sclerosis (dcSSc). An estimated total of 12 to 15 subjects will receive belumosudil 200 mg administered orally (PO) twice daily (BID) for 52 weeks. The primary analysis will be at 24 weeks.

Conditions: Diffuse Cutaneous Systemic Sclerosis

TTHX1114(NM141) in Combination With DWEK/DSO

NCT04676737

Open label, single-treatment, with a concurrent non-treatment control

Conditions: Fuchs' Endothelial Dystrophy, Fuchs Dystrophy, Fuchs

TXA in Spine Surgery

NCT04672213

As tranexamic acid (TXA) becomes more prevalent, all patients are receiving the same dose and method of delivery regardless of their pre-operative risk of transfusion. Therefore, the aim of the study is to determine whether or not repeated dosing of oral or a different method of delivery like intravenous (IV) TXA reduces the post-operative reduction in hemoglobin, hematocrit, number of transfusions, and postoperative blood loss following open spine surgery.

Conditions: Postoperative Blood Loss Following Spine Surgery
Phase: Not Applicable

Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm

NCT04671082

This is a double-blind, randomized, placebo-controlled, multicenter study of the efficacy and safety of tolperisone (a non-opioid) or placebo administered in subjects with pain due to acute back muscle spasm.

Conditions: Back Muscle Spasm, Back Pain, Back Strain, Back Spasm Upper, Muscle Spasm, Acute Pain