Ohio Clinical Trials

A listing of Ohio clinical trials actively recruiting patient volunteers.

Every four years, Americans all around the country can can count on a deluge of news about Ohio, named for the Ohio River (“Good River”) that runs through it. A state since 1803, it was the 17th state to join the union. Today, its major cities include Columbus, Cincinnati, Akron, and Cleveland, the latter still known for its rock and roll music. The state is inextricably intertwined with the history of aerospace, being home to the Wright Brothers and the birthplace of several early astronauts. Ohio’s cities are served by a number of excellent hospitals, including Ohio Health Riverside Methodist Hospital.

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3061 trials found

Enhancing Permanency in Children and Families

NCT04700696

The Enhancing Permanency in Children and Families (EPIC) program is a collaborative effort between the Ohio State University College of Social Work, two county offices of the Ohio Department of Job and Family Services, two juvenile courts and local behavioral health agencies. The goal of EPIC is to use three evidence-based and evidence-informed practices to reduce abusive and neglectful parenting, reduce addiction severity in parents, and improve permanency outcomes for families involved with th ...

Conditions: Substance Abuse, Substance Use, Child Abuse, Neglect, Child
Phase: Not Applicable

An Exploratory Study of PQ Grass 27600 SU

NCT04687059

PQGrass309 is aimed at exploring the expected average treatment effect of PQ Grass 27600 SU cumulative dose on symptom and medication score in a field setting. The study will enrol adult subjects with seasonal allergic rhinitis and/or rhinoconjunctivitis (SAR) induced by grass pollen exposure.

Conditions: Rhinitis, Allergic, Seasonal
Phase: Phase 2/3

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis

NCT04687475

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis

Conditions: Cystic Fibrosis, Lung Transplant; Complications
Phase: Not Applicable

A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)

NCT04688164

This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.

Conditions: Major Depressive Disorder

Phase Ib Study of the Safety of T-DXd and Durvalumab With Chemotherapy in Advanced or Metastatic HER2+ Non-squamous NSCLC

NCT04686305

DESTINY-Lung03 will investigate the safety and tolerability of trastuzumab deruxtecan in combination with chemotherapy in patients with HER2 positive advanced and metastatic non-small lung cancer. The efficacy will be also analyzed as a secondary endpoint.

Conditions: Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain

NCT04681183

This pilot research study is being performed to learn more about pain and look at how pain changes brain chemistry and function. The research team would like to learn new information to better control chronic pain after surgery. This information collected in this research will be used to plan possible future visits. Participants in this study are being asked to participate because they are scheduled for an upcoming surgery. The research team would like to observe them before and after their surg ...

Conditions: Chronic Post-surgical Pain

Intraoperative NOL Titration

NCT04679818

To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.

Conditions: Anesthesia; Adverse Effect

Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough

NCT04678206

This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 2b adaptive dose-finding study of BLU-5937 in participants with Refractory Chronic Cough (RCC).

Conditions: Refractory Chronic Cough

The Healthy Cookie Energy Study: Understanding How Healthy Cookies Affect Mitochondrial Biology

NCT04677920

The proposed research is an intervention and feasibility pilot trial designed to determine if short-term consumption of healthy cookies made with an oil rich in linoleic acid can influence mitochondria biology in white blood cells and muscle. The hypothesis of the study is that consuming 1 healthy cookie rich in linoleic acid each day for two weeks will improve mitochondrial biology in white blood cells and muscle.

Conditions: Healthy Adults
Phase: Not Applicable

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

NCT04669665

The purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major Depressive Disorder (MDD) and suicidality, in participants who are assessed to be at imminent risk for suicide, as measured by the change from baseline on the Montgomery-Asberg Depression Rating Scale (MADRS) total score at 24 hours post first dose.

Conditions: Depressive Disorder, Major, Suicidal

Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm

NCT04671082

This is a double-blind, randomized, placebo-controlled, multicenter study of the efficacy and safety of tolperisone (a non-opioid) or placebo administered in subjects with pain due to acute back muscle spasm.

Conditions: Back Muscle Spasm, Back Pain, Back Strain, Back Spasm Upper, Muscle Spasm, Acute Pain

Basic Assessment of Safety and Minimally Invasive Stimulation Via Injectrode

NCT04672096

The objectives of this non-significant risk (NSR) study are to evaluate the safety of the short term placement of the Basmati Injectrode for up to 28 days and the efficacy of conducting electrical current to stimulate subcutaneous nerves on the explant date just prior to explant.

Conditions: Safety Issues
Phase: Not Applicable