Wisconsin Clinical Trials

A listing of Wisconsin clinical trials actively recruiting patient volunteers.

Beloved around the United States as the country’s biggest producer of cheese, Wisconsin is a Midwestern state with coastlines on Lake Michigan and Lake Superior. Admitted to the union in 1848, it’s the home of the Harley-Davidson Museum showcasing classic bikes. Its biggest cities include Milwaukee, the capital of Madison, Kenosha, and Green Bay. The Green Bay Packers inspire some of the most devout fans in all of football. When it comes to healthcare, Wisconsin is on the grow. Aurora St. Luke’s Medical Center in Milwaukee is the state’s leading provider, but Wisconsin is also dotted with other cutting-edge hospitals.

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1186 trials found

Evaluation of Geistlich Fibro-Gide® in Comparison to CTG for the Treatment Around Implants

NCT04703738

This double blind, randomized, parallel study evaluates the non-inferiority of Geistlich Fibro-Gide® in comparison to connective tissue graft for soft tissue volume augmentation around dental implants

Conditions: Soft Tissue Defect
Phase: Not Applicable

An Exploratory Study of PQ Grass 27600 SU

NCT04687059

PQGrass309 is aimed at exploring the expected average treatment effect of PQ Grass 27600 SU cumulative dose on symptom and medication score in a field setting. The study will enrol adult subjects with seasonal allergic rhinitis and/or rhinoconjunctivitis (SAR) induced by grass pollen exposure.

Conditions: Rhinitis, Allergic, Seasonal
Phase: Phase 2/3

Manual Physical Therapy During Pregnancy on Post Partum Perineal Trauma and Pain

NCT04660708

The purpose of this study is to explore the impact of pelvic floor physical therapy during pregnancy on delivery and the impact on the woman's body and function. Currently there have not been any studies to our knowledge that have examined this relationship and the outcomes for the pregnant patient. The current research that is available is on pelvic floor training and perineal massage during pregnancy with positive outcomes. The questions we are looking to answer include: Does pelvic floor phy ...

Conditions: Pregnancy Related, Delivery; Injury, Maternal, Pelvic Floor Disorders
Phase: Not Applicable

Effects of Oral Cancer Surgery on Upper Esophageal Opening During Swallowing

NCT04658342

The purpose of this study is to investigate pre-operative, post-operative and post-radiation upper esophageal sphincter opening measures in oral cancer patients, compare measures to age- and gender-matched healthy adults, and determine relationships with patient swallowing outcomes and quality of life.

Conditions: Cancer of Head and Neck

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.

NCT04625725

This study will assess the safety and efficacy of a single dose of AZD7442(× 2 IM injections) compared to placebo for the prevention of COVID-19.

Conditions: COVID-19

RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease

NCT04616924

A 2-part multi-center, Phase 3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of RHB-204 in adult subjects with underlying nodular bronchiectasis and documented MAC lung infection.

Conditions: Pulmonary Mycobacterium Avium Complex Infection, Bronchiectasis, Lung Diseases

Efficacy and Safety of MEDI6570 in Patients With a History of Myocardial Infarction

NCT04610892

A Phase IIB Parallel group Study to Evaluate the Efficacy and Safety of MEDI6570 in Participants with a Prior Myocardial Infarction.

Conditions: Coronary Heart Disease (CHD)

A Study of Mirikizumab in Healthy Participants

NCT04607733

The main purpose of this study is to compare the amount of mirikizumab that gets into the blood stream and how long it takes the body to get rid of it, when given as a solution formulation via manual prefilled syringe or autoinjector. The information about any adverse effects experienced will be collected and the tolerability of mirikizumab will also be evaluated. Screening is required within 28 days prior to the start of the study. For each participant, the total duration of the clinical trial ...

Conditions: Healthy

A Study Assessing the Long-Term Safety and Tolerability of RG6147 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT04607148

The purpose of this study is to evaluate the long-term safety and tolerability of intravitreal (ITV) injections of RG6147 administered every 4 weeks (Q4W) or every 8 weeks (Q8W) in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) who completed the parent study (NCT03972709/GR40973).

Conditions: Macular Degeneration, Age-Related, Geographic Atrophy

A Study To Investigate The Safety, Tolerability And Pharmacokinetics (PK) Of RO7223280 Following Intravenous Administration In Healthy Participants

NCT04605718

The Study consists of 2 Parts: Part 1 (Single Ascending Dose/SAD) and Part 2 (Multiple Ascending Dose/MAD). Part 1 will investigate the safety, tolerability and PK of single-ascending intravenous (IV) doses of RO7223280 in healthy participants. Part 2 will investigate the safety, tolerability and PK of multiple-ascending IV doses of RO7223280 in healthy participants. Part 2 will only start after the completion of Part 1 (SAD). Progression from Part 1 to Part 2 will be based on a satisfactory rev ...

Conditions: Healthy Volunteers

Immune Modulators for Treating COVID-19

NCT04593940

ACTIV-1 IM is a master protocol designed to evaluate multiple investigational agents for the treatment of moderately or severely ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The research objectives are to evaluate each agent with respect to speed of recovery, mortality, illness severity, and hospital resource utilization. Each agent will be evaluated as add-on therapy to the standard of care (SoC) in use at the local clinics, including remdesivir (prov ...

Conditions: Covid19

Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

NCT04589845

TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are tumor mutational burden (TMB)-high as identified by a validated next-generation sequencing (NGS) assay. Participants with solid tumors ...

Conditions: Solid Tumors