Opioid Antagonism in Hypogonadotropic Hypogonadism
NCT04975334
Recruiting
The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with hypogonadotropic hypogonadism (HH).
Gender:
MALE
Ages:
Between 18 years and 75 years
Trial Updated:
07/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism, Low Testosterone
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RIC-NEC Randomized Controlled Trial
NCT05279664
Recruiting
Necrotizing enterocolitis (NEC) is a serious intestinal disease of preterm and term neonates which remains a major cause of intestinal failure, and an unsolved clinical challenge in pediatrics. While overall mortality of preterm infants continues to decrease due to improvements in general neonatal care, mortality caused by NEC remains high (up to 30-50%) and survivors suffer from reduced quality of life, and long-term disabilities such as debilitating complications of intestinal failure, poor gr... Read More
Gender:
ALL
Ages:
0 weeks and above
Trial Updated:
07/22/2025
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio +3 locations
Conditions: Necrotizing Enterocolitis
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Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy
NCT05178992
Recruiting
The objective of this study is to demonstrate the impact of a socially assistive robot system on reducing apathy among cognitively impaired older adults residing in long term care facilities. Earlier phases of this project demonstrated the feasibility and acceptability of the robotic system. First, investigators will improve the social robotic interaction architecture through additional software development, enhance its versatility, and make it easy for non-experts to run. Second, 188 participan... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/22/2025
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Alzheimer Disease
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Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
NCT04648969
Recruiting
The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism
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An Adaptive Intervention to Increase Engagement to Community-Based Care After an ED Admission
NCT07092345
Recruiting
The goal of this study is to develop a feasible brief, family-based adaptive intervention, via SMART design, for youth with suicidal and non-suicidal self-injurious behavior (SSIB) to increase community-based mental health (MH) care attendance and reduce SSIB risk post emergency department (ED) admission. The intervention will focus to increase understanding on youth MH literacy, MH communication, and MH engagement. Integrating an adaptive intervention via a SMART design in the ED could address... Read More
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
07/22/2025
Locations: Hasbro Children's Hospital, Providence, Rhode Island
Conditions: Suicidal and Self-injurious Behavior, Linkage to Care
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Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
NCT05120635
Recruiting
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some... Read More
Gender:
ALL
Ages:
Between 12 years and 70 years
Trial Updated:
07/22/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Fear, GAD, Emotional Memory, PTSD
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Parenteral Ascorbic Acid Repletion in TransplantatIon
NCT04756063
Recruiting
A single-center, randomized, double-blinded placebo-controlled trial is proposed to investigate administration of supraphysiologic doses of ascorbic acid (vitamin C, AA) to patients undergoing liver transplantation. Participants randomized to the intervention group will receive intravenous (IV) AA 1500 mg every 6 hours for 48 hours. Participants randomized to the control group will receive a saline placebo. The primary study outcome will be a change in the Sequential Organ Failure Assessment (SO... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/22/2025
Locations: University of Wisconsin Hospital and Clinics, Madison, Wisconsin
Conditions: Liver Transplant Failure and Rejection
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A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
NCT05076175
Recruiting
The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be administered orally to pediatric participants with moderate to severe active ulcerative colitis (UC) who have had an inadequate response to conventional therapy.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
07/22/2025
Locations: Local Institution - 0041, Phoenix, Arizona +85 locations
Conditions: Colitis, Ulcerative
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Studying Rehabilitation Treatments Using Video to Improve Recovery for Adults With Physical Disabilities
NCT07092293
Recruiting
This study aims to better understand how occupational therapists provide rehabilitation for adults recovering from stroke or spinal cord injury (SCI), with a focus on improving arm and hand function. Using video recordings of real outpatient therapy sessions, researchers will identify the key elements of treatment, such as the types of activities, the therapist's techniques, and how patients respond. The study will use the Rehabilitation Treatment Specification System (RTSS), a framework designe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Ohio State Wexner Medical Center, Columbus, Ohio
Conditions: Stroke, Spinal Cord Injury, Occupational Therapy
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A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
NCT05296798
Recruiting
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal growth factor receptor 2 (HER2)-positive, estrogen receptor (ER)-positive advanced breast cancer (metastatic or locally advanced disease not amenable to curative treatment) who have not previously received a systemic non-hormonal anti-cancer therapy in the adva... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Arizona Clinical Research Center, Inc, Tucson, Arizona +236 locations
Conditions: Locally Advanced or Metastatic Breast Cancer
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Virtual Art Therapy Assisted Re-Integration to Improve Biopsychosocial Outcomes in Adolescent and Young Adult Cancer Survivors, AVATARS Trial
NCT07089927
Recruiting
This clinical trial tests the feasibility, usability and acceptability of a virtual art therapy assisted re-integration (AVATARS) intervention to improve biopsychosocial outcomes, such as anxiety, depression, resilience, emotional regulation, stress, and cognition, among adolescent and young adult (AYA) cancer survivors. AYA cancer survivors (especially those treated at adult cancer centers) historically experience worse psychosocial outcomes and lack age appropriate psychosocial support compare... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
07/22/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations
Conditions: Malignant Solid Neoplasm
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Transcranial Direct Current Stimulation in Children With Autism
NCT07092280
Recruiting
Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who show an absence or a plateau in various skills. Deficits in executive functioning are likely to be involved in many of these cognitive and learning disabilities due to poor functioning of the prefrontal cortex. Currently, the use of biological methods for improving learnin... Read More
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
07/22/2025
Locations: New York State Institute for Basic Research, Staten Island, New York
Conditions: Autism Spectrum Disorder, Executive Dysfunction
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