Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
NCT04798274
Recruiting
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric acid (GABA). They want to learn how abnormalities in the GABA system may contribute to ASD. Objective: To see if repetitive transcranial magnetic stimulation (rTMS) creates short-term changes in how different parts of the brain communicate. Eligibility: Right-handed people ages 11-17 with ASD, and healthy volunteers ages 18-25. Des... Read More
Gender:
ALL
Ages:
Between 11 years and 25 years
Trial Updated:
05/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Autism Spectrum Disorder
Register for Updates
Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.
NCT05024695
Recruiting
Evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.
Gender:
ALL
Ages:
46 years and above
Trial Updated:
05/21/2025
Locations: Arizona Advanced Eye Research Institute, Glendale, Arizona +36 locations
Conditions: Glaucoma
Register for Updates
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy
NCT05206513
Recruiting
The primary objective of this study is to evaluate the efficacy of valbenazine versus placebo on improving chorea in pediatric and adult participants who have dyskinesia due to cerebral palsy (DCP) with choreiform movements.
Gender:
ALL
Ages:
Between 6 years and 70 years
Trial Updated:
05/21/2025
Locations: Neurocrine Clinical Site, San Diego, California +42 locations
Conditions: Dyskinesia, Cerebral Palsy
Register for Updates
A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer
NCT05365581
Recruiting
Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers are looking at ways to attack CLDN18.2 to help control tumors. ASP2138 is thought to bind to CLDN18.2 and a protein on a type of immune cell called a T-cell. This "tells" the immune system to attack the tumor. ASP2138 is a potential treatment for people with stomach cancer, gastroesophageal junction cancer (GEJ cancer) or pancreatic cancer. GEJ is where the tube tha... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: University of California Irvine Medical Center, Orange, California +40 locations
Conditions: Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma, Pancreatic Adenocarcinoma
Register for Updates
Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults
NCT05490927
Recruiting
The purpose of this study is to examine whether microaggressions relate to multimodal facets of smoking behavior, subjective withdrawal, and urge/craving. Additionally, the second aim is to examine whether smoking deprivation moderates the relation between microaggressions and multiple facets of smoking behavior, subjective withdrawal, and urge/craving.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: RESTORE Laboratory: Research on Emotion, Substance Treatment Outcomes, and Racial Equity, Houston, Texas
Conditions: Smoking, Discrimination, Racial
Register for Updates
Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC
NCT05595460
Recruiting
This study aims to determine the safety, preliminary antitumor activity, and pharmacokinetics (PK) of RYZ101 in combination with standard of care (SoC) therapy consisting of carboplatin + etoposide + atezolizumab in untreated subjects with somatostatin receptor expressing (SSTR+) ES-SCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Research Facility, Los Angeles, California +14 locations
Conditions: SCLC,Extensive Stage
Register for Updates
Outreach Core Activities
NCT05832177
Recruiting
The Ponce Health Sciences University-Moffitt Cancer Center (PSHU-MCC) U54 Outreach Core (OC) goal is to increase community cancer awareness, community engagement (CE) and participation in cancer health disparities research and outreach in Hispanic/Latino communities through the following: Aim 1: To develop, deliver, and disseminate cancer education and outreach activities to Hispanic/Latino community members to reduce cancer health disparities. Aim 2: To enhance capacity for mutually beneficia... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Moffitt Cancer Center, Tampa, Florida +1 locations
Conditions: Cancer Education, Spanish Language Cancer Education
Register for Updates
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
NCT05920356
Recruiting
The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/21/2025
Locations: Sansum Clinic, Santa Barbara, California +359 locations
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Register for Updates
Treating Caregivers Who Smoke at AFCH
NCT06051474
Recruiting
The purpose of this research study is to 1) see if a smoking cessation program is something that caregivers will use while their child is hospitalized, 2) see if caregivers think this program is something we should institute across the hospital, and 3) see if this program can help caregivers reduce their smoking. Participants will: * Complete a survey regarding smoking behavior and thoughts about quitting; * Undergo a 20-minute counseling session; and, * Use nicotine patches and mini-lozenges... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: American Family Children's Hospital, Madison, Wisconsin
Conditions: Smoking, Smoking Cessation
Register for Updates
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
NCT06112353
Recruiting
The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and tolerance for solid food (GI-2 recovery) following bowel resection surgery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: UC Irvine Medical Center, Orange, California
Conditions: Intestinal Disease
Register for Updates
Respiratory Strength Training in Heart Transplant Recipients
NCT06190171
Recruiting
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery. Previous studies have shown that breathing exercises can improve breathing, cough, and swallow function in patients with other diseases/conditions. The current study will investigate the impact of a preoperative respiratory muscle strength training program on breathing and cough function, swallow function, patient-reported eating and swallowing fatigue... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/21/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Dysphagia, Heart Transplant Recipients
Register for Updates
A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Disease
NCT06248619
Recruiting
The study consists of a randomized double-masked, placebo-controlled, parallel-group, multicenter trial with an optional open-label treatment period for proptosis non-responders who complete the Double-masked Treatment Period.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/21/2025
Locations: Catalina Eye Care - NVISION - PPDS, Tucson, Arizona +53 locations
Conditions: Thyroid Eye Disease
Register for Updates