Iadademstat in Combination With Paclitaxel in Relapsed/Refractory SCLC and Extrapulmonary High Grade NET
Recruiting
This is a non-randomized single-arm, two cohorts, phase II study of iadademstat in combination with weekly paclitaxel in patients with relapse/refractory SCLC or extrapulmonary G3 Neuroendocrine Carcinomas. A total of 42 patients with SCLC (21 patients) and G3 NEC (21 patients) will be enrolled (including those enrolled in the safety lead-in portion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: Roswell Park Cancer Institute, Buffalo, New York +2 locations
Conditions: Small-cell Lung Cancer, Neuroendocrine Carcinoma
To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation
Recruiting
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Central Airway Obstruction
Perineal Massage for Pessary Examinations
Recruiting
Pessaries are effective non-surgical devices for reduction of prolapse. However, use of pessaries are limited in some women due to patient discomfort. While lidocaine can be used to improve pessary checks, its use may be limited due to supply chain shortages, lack of insurance coverage, and optimization of resource utilization. More techniques to improve pessary examination comfort are needed. Perineal massage prior to delivery and at the time of active labor has been noted to reduce perineal tr... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: UNC Urogynecology, Raleigh, North Carolina
Conditions: Prolapse, Vaginal, Stress Urinary Incontinence, Pessaries, Pain
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Recruiting
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
08/22/2024
Locations: University of Iowa College of Dentistry and Dental Clinics, Iowa City, Iowa
Conditions: Dental Pulp Necroses
Sex Differences in the Response to Abstinence From Alcohol.
Recruiting
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that abstinence affects drinking differently in women compared to men. In the present study, the investigators propose to study how men and women respond to abstinence, and whether this information can be used to improve intervention and prevention strategies.
Gender:
ALL
Ages:
Between 21 years and 35 years
Trial Updated:
08/21/2024
Locations: University Hospital, Indianapolis, Indiana
Conditions: Alcohol Use Disorder
Improving Comprehensive Care of Cancer Patients
Recruiting
Cancer survivors have unique healthcare needs, including managing serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, and psychosocial support. Nearly 70% of survivors have at least one comorbid chronic condition in addition to cancer, which complicates the delivery of quality cancer care. Medically underserved patients, who bear the highest burden of multiple chronic conditions, are at increased risk for poor outcomes during and after cancer treatme... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Breast Cancer, Gastrointestinal Cancer, Hematologic Cancer
Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)
Recruiting
A multicenter pragmatic randomized trial of nulliparous women undergoing a term (≥37 weeks) induction of labor wherein the provider intends to use a Foley catheter for cervical ripening. The investigators will be comparing outpatient cervical ripening with a Foley catheter to routine inpatient cervical ripening (Foley +/- other method). With this trial, the investigators aim to test our central hypothesis that outpatient Foley will decrease the primary Cesarean Delivery (CD) rate and risk of mat... Read More
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
08/21/2024
Locations: Christiana Care Health Services, Inc., Newark, Delaware +3 locations
Conditions: Induction of Labor Affected Fetus / Newborn
Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis
Recruiting
The aim of this study is to understand how well a 6-week virtual yogic breathing exercise program (YBEP) will improve breathing, speech, and emotional well-being in people with amyotrophic lateral sclerosis (ALS).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/21/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Amyotrophic Lateral Sclerosis, Myasthenia Gravis
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
Recruiting
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical function, psychological well-being, quality of life, and occupational function, as well as increased prevalence of fatigue, pain, depression, and anxiety. The objective of the proposed study is to determine the efficacy of cognitive behavioral therapy for insomnia (CBT-I) to... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/21/2024
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Multiple Sclerosis, Insomnia
Evaluating the Impact of a School-based Fruit and Vegetable Co-op on Cardiometabolic Child and Parents Health in a Persistent Poverty Area
Recruiting
The purpose of this study is to examine the effects of the (Brighter Bites (BB) intervention compared to a wait-list control group 9 months after the intervention on changes in primary child outcomes (HbA1c, and vegetable intake), on changes in secondary outcomes (household food security status, parent and child dietary behaviors, and home access/availability of fruits and vegetables (FV)), and the mediational influence of changes in food security status, parent outcomes, and home environment me... Read More
Gender:
ALL
Ages:
Between 6 years and 9 years
Trial Updated:
08/21/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Child Obesity, Cardiometabolic Health
TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Recruiting
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
08/21/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Cardiovascular Diseases
S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +841 locations
Conditions: Multiple Myeloma