A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
NCT06764771
Recruiting
This purpose of this study is to determine if experimental treatment with BMS-986488, alone, or in combinations is safe, tolerable, and has anti-cancer activity in patients with advanced malignant tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey +7 locations
Conditions: Advanced Malignant Tumors
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Tailored Electronic Intervention to Improve Therapy in a Diverse Cohort of Patients With Heart Failure
NCT06847438
Recruiting
Recent medical guidelines for the management of heart failure (HF) have established a combination of specific classes of medications as the best treatment for patients with heart failure with reduced ejection fraction (HFrEF). However, studies have shown that these medications, known together as guideline-directed medical therapy (GDMT), are not being used in clinical practice less often than they could be. Several tools to promote broader use of these treatments (including patient checklists) h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Emory Saint Joseph's Hospital, Atlanta, Georgia +3 locations
Conditions: Heart Failure
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Impact of Vitamin D Supplements on Mental Health and Milk Composition in Mothers Living in Idaho
NCT06919718
Recruiting
Mothers of preterm infants experience exaggerated emotional stressors compared to those typically associated with new motherhood, making these women particularly vulnerable to postpartum depression. As many as 70% of mothers of preterm infants experience postpartum depression compared to only 12.5% of those delivering full-term infants. Increased stress and depression during this critical period are detrimental because they hamper a mother's ability to care for her infant and are associated with... Read More
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
04/02/2025
Locations: Kootenai Health, Coeur d'Alene, Idaho +1 locations
Conditions: Maternal Stress
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The Use of Leukapheresis to Support HIV Pathogenesis Studies
NCT01161199
Recruiting
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges. Also, there is emerging consensus that persistent HIV-associated disease occurs during long-term highly active antiretroviral therapy (HAART). This disease may be due to either direct drug-toxicity and/or persistent viral replication/production and/or persistent HIV-associated inflammation... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
NCT03998202
Recruiting
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/02/2025
Locations: Beebe South Coastal Health Campus, Millville, Delaware +141 locations
Conditions: Colorectal Cancer, Sarcopenia
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A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
NCT04774718
Recruiting
This study will evaluate the safety, pharmacokinetics, and efficacy of alectinib in children and adolescents with ALK fusion-positive solid or CNS tumors for whom prior treatment has proven to be ineffective or for whom there is no satisfactory standard treatment available.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
04/02/2025
Locations: Lucile Packard Children's Hospital, Palo Alto, California +32 locations
Conditions: ALK Fusion-positive Solid or CNS Tumors
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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
NCT04951622
Recruiting
The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravis (gMG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Neuromuscular Research Center and Clinic, Paradise Valley, Arizona +110 locations
Conditions: Myasthenia Gravis
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Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
NCT05303064
Recruiting
To compare changes in body mass index (BMI) Z-score following treatment with OLZ/SAM vs olanzapine
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
04/02/2025
Locations: Alkermes Investigator Site, Dothan, Alabama +43 locations
Conditions: Schizophrenia, Bipolar I Disorder
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Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease
NCT05517421
Recruiting
To evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Site Number - 1557, Beverly Hills, California +92 locations
Conditions: Thyroid Eye Disease
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Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
NCT05703256
Recruiting
The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Major Depressive Disorder
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Ovarian Tissue Cryopreservation in the Setting of Gender-affirming Therapy
NCT05863676
Recruiting
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. To optimize techniques for cryopreservation of ovarian tissues, including determining efficacy of cryopreservation techniques. 2. To investigate factors affecting ovarian tissue and follicles, such as previous treatment with leuprolide acetate, or hormone therapy
Gender:
FEMALE
Ages:
9 years and above
Trial Updated:
04/02/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Gender Dysphoria, Transgender
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Hydroxycitrate: A Novel Therapy for Calcium Phosphate Urinary Stones
NCT06003348
Recruiting
This study tests whether hydroxycitrate, a molecule closely related to citrate, can reduce calcium phosphate stone recurrence.
Gender:
ALL
Ages:
Between 21 years and 99 years
Trial Updated:
04/02/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Calcium Phosphate Kidney Stones
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