A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
Recruiting
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will evaluate how safe and effective risankizumab is compared to vedolizumab in treating adult participants with moderate to severe UC who are naive to targeted therapies (TaTs). Risankizumab and vedolizumab are approved medications for moderate to severe UC in multiple countries. Participants who meet the eligibility criteria... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/29/2025
Locations: Gastro Care Institute /ID# 274873, Lancaster, California +42 locations
Conditions: Ulcerative Colitis
Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 )
Recruiting
This study aims to determine safety, tolerability, recommended phase 2 dose (RP2D), and preliminary antitumor activity of 225Ac-SSO110 with standard of care (SoC) therapy in patients with somatostatin receptor 2 expressing (SSTR2+) extensive-stage small cell lung cancer (ES-SCLC) and recurrent locally advanced or metastatic Merkel cell carcinoma (MCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Biogenix Molecular, Miami, Florida +3 locations
Conditions: Small Cell Lung Cancer Extensive Stage, Merkel Cell Carcinoma
Pivotal Study for the Cardiac Performance System (CPS)
Recruiting
This multi-center, observational study evaluates the accuracy of the Cardiac Performance System (CPS), a non-invasive device, for measuring hemodynamic parameters in adult patients undergoing clinically indicated right heart catheterization. The study compares CPS measurements to invasive measurements to assess agreement and potential clinical utility.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Huntsville Hospital Heart Center, Huntsville, Alabama +3 locations
Conditions: Cardiovascular Diseases
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986368 in participants with Multiple Sclerosis Spasticity
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/29/2025
Locations: Local Institution - 0050, Scottsdale, Arizona +48 locations
Conditions: Multiple Sclerosis Spasticity
ivWatch in Prevention of Extravasation of Vesicants in an Oncology Setting
Recruiting
This study aims to determine the feasibility of using the ivWatch (registered trademark) device to determine if there is an infiltration at the site of a peripheral intravenous (PIV) catheter. An infiltration is when the IV fluid leaks out of a vein and into the surrounding tissue. If medication starts leaking outside the vein, it can cause damage to the surrounding tissue. Using the ivWatch device may identify leaking fluid before the nurse is able to visually observe the signs or symptoms of t... Read More
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
07/29/2025
Locations: Roswell Park Comprehensive Cancer Center, Buffalo, New York
Conditions: Oncology, Extravasation
Dyadic Life Review Intervention for Older Patients With Advanced Cancer) and Their Caregivers
Recruiting
The purpose of this study is to test the feasibility of a pilot Randomized Controlled Trial (RCT) comparing Dyadic Life Review (DLR) intervention in older adults with advanced cancer and their caregivers to Care-as-Usual (CAU) group, which involves a referral to social work.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
07/29/2025
Locations: University of Rochester, Rochester, New York
Conditions: Cancer
ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours
Recruiting
Adcendo ApS is conducting a phase 1 study of an investigational drug called ADCE-T02 (previously known as AMT-754), a tissue factor targeted antibody-drug conjugate which may be used in the future as a possible treatment for advanced solid tumors. The main purpose of the study is to determine the Maximum Tolerated Dose (MTD), the recommended dose and the safety and tolerability of ADCE-T02 when given as a single therapy over a range of different dose levels.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Yale University Cancer Center, New Haven, Connecticut +6 locations
Conditions: Advanced Solid Tumor
Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria
Recruiting
The purpose of this study is to explore the effect and Mechanism of Action (MoA) of remibrutinib (LOU064) vs. placebo on clinical outcomes in participants with Chronic Urticaria (CU), including both Chronic Spontaneous Urticaria (CSU) and Chronic Inducible Urticaria (CINDU).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/29/2025
Locations: Ziaderm Research LLC, North Miami Beach, Florida +16 locations
Conditions: Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)
Hirschsprung Disease Genetic Study
Recruiting
Hirschsprung disease is a genetic condition caused by lack of nerve cells in varying lengths of the intestines. This study will investigate the complex genetic basis of the disease, which involves multiple interacting genetic factors.
Gender:
ALL
Ages:
Between 1 week and 100 years
Trial Updated:
07/29/2025
Locations: New York University School of Medicine, New York, New York
Conditions: Hirschsprung Disease
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Local Institution - 0066, Birmingham, Alabama +46 locations
Conditions: Lung Cancer
Cannabis for Palliative Care in Cancer
Recruiting
Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD (Cannabidiol) with and without THC (Delta-9-tetrahydrocannabinol) ve... Read More
Gender:
ALL
Ages:
25 years and above
Trial Updated:
07/29/2025
Locations: Anschutz Health Sciences Building, Aurora, Colorado
Conditions: Sleep, Anxiety, Depression, Pain
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Recruiting
The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Southern Arizona VA Health Care System, Tucson, Arizona +274 locations
Conditions: Non-small Cell Lung Cancer