There are currently 1887 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
NCT05235113
Recruiting
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies. However, those with poor motor and cognitive abilities often struggle to visit rehabilitation centers, leading to high dropout rates and low adherence to unsupervised programs. A remote exercise program tailored for individuals with cognitive impairments is urgently needed to prese... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
03/10/2025
Locations: UCLA, Los Angeles, California
Conditions: Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
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GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery
NCT05900037
Recruiting
This is a pre-market, prospective, randomized (1:1), multicenter, pivotal clinical investigation. The purpose of this investigation is to determine the clinical performance of GATT-Patch as compared with SURGICEL® Original for the management of minimal, mild, or moderate bleeding during minimally invasive liver and gallbladder surgery.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/10/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Intraoperative Bleeding, Liver Diseases, Gallbladder Diseases, Hemorrhage, Surgical
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Cardiac-Control Affecting Learning Through Mindfulness (CALM)
NCT06410157
Recruiting
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
03/10/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Age-related Cognitive Decline, Alzheimer Disease
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Early Feeds in Gastroschisis
NCT06878950
Recruiting
This study aims to evaluate the feasibility of initiating early feeds in neonates with gastroschisis, a condition where infants are born with their intestines outside the body.
Gender:
ALL
Ages:
Between 0 days and 1 year
Trial Updated:
03/10/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Gastroschisis
Register for Updates
A Study of LM-24C5 For Advanced Solid Tumors
NCT06187402
Recruiting
To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: University of Southern California (USC) - Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Advanced Solid Tumor
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The HPV 9-10 Trial: Early Initiation of HPV Vaccination
NCT04722822
Recruiting
Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not have their children vaccinated when it is recommended at age 11 or 12. In this study, we will examine in a randomized trial whether earlier initiation of the vaccine at age 9-10 years will result in less parental refusal and higher rates of full vaccination at younger ages, before early sexua... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: HPV
Register for Updates
A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372
Recruiting
The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
03/07/2025
Locations: University of California LA, Los Angeles, California
Conditions: Mesothelioma
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Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
NCT04883463
Recruiting
This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach. Participants may qualify for the study if they are male or female 18-75 years old, are at least 1 year after original injury, have injury at C2 to C7 level, and dependent on mechanical ventilation to help them breathe. Additionally, they need to be able to attend... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/07/2025
Locations: Semel Institute of Neuroscience at UCLA, Los Angeles, California +1 locations
Conditions: Spinal Cord Injuries
Register for Updates
Recording of Intraoperative Spinal Cord Stimulation and Monitoring
NCT05356286
Recruiting
Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Cervical Stenosis, Disk, Herniated, Spondylosis
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Family Intervention to Prevent Childhood Obesity
NCT05606731
Recruiting
Consumption of sweetened beverages, media-viewing, and physical activity patterns are often established during early childhood, and family-based obesity interventions show effectiveness in shaping healthy behaviors and weight outcomes for young children, including Latino children. Missing from these interventions, however, are methods to increase accessibility and dissemination to multiple family caregivers. The proposed work will use a randomized study design to evaluate the impact a family-bas... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/07/2025
Locations: Head Start, Los Angeles, California
Conditions: Childhood Obesity
Register for Updates
Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
NCT05701059
Recruiting
This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be a... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/07/2025
Locations: UCLA, Los Angeles, California
Conditions: Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
Register for Updates
Spinal Cord Stimulation to Shorten Ventilator Dependence in ARDS Patients
NCT05928052
Recruiting
This is an early phase, proof-of-concept clinical trial assessing the safety and feasibility of non-invasive spinal cord stimulation to prevent respiratory muscle atrophy in mechanically ventilated ARDS patients. The investigators will recruit 10 elective surgery patients (surgery cohort) and 10 ARDS patients (ARDS cohort) for this study. A non-invasive, alpha-prototype Restore Technology stimulator using hydrogel surface electrodes will be used to stimulate the spinal cord at the cervical or th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Respiratory Distress Syndrome
Register for Updates