There are currently 2033 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Mechanisms of Resistance to PSMA Radioligand Therapy
NCT05435495
Recruiting
This is a multicenter, correlative study to existing Lutetium based prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) trials and uses.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/08/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Prostate Cancer
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PIMR and Pulmonary Vascular Disease
NCT05843461
Recruiting
The findings from this innovative, first-in-man, prospective pilot study will elucidate the role of PIMR and RV-IMR in pre-capillary PH. The study cohort will consist of patients with pulmonary pressures ranging from normal (advanced lung disease patients undergoing lung transplant evaluation) to severe PH (PAH and CTEPH patients), and thus will allow for identification of a PIMR cutoff. Participants will include: 1) advanced lung disease patients undergoing bilateral heart catheterization as pa... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/08/2024
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Pulmonary Hypertension
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Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
NCT05701059
Recruiting
This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be a... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/06/2024
Locations: UCLA, Los Angeles, California
Conditions: Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
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Transformative Research in Diabetic Nephropathy
NCT02986984
Recruiting
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of o... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
01/05/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Diabetic Nephropathies, Diabetic Glomerulosclerosis
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Liver Cirrhosis Network Cohort Study
NCT05740358
Recruiting
Liver Cirrhosis Network (LCN) Cohort Study is an observational study designed to identify risk factors and develop prediction models for risk of decompensation in adults with liver cirrhosis. LCN Cohort Study involves multiple institutions and an anticipated 1200 participants. Enrolled participants will have study visits every 6 months (180 days), with opportunities to complete specific visit components via telehealth or remotely. Visits will include collection of questionnaire data and the in-p... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Keck Medical Center of USC, Los Angeles, California +1 locations
Conditions: Cirrhosis, Cirrhosis, Liver, Cirrhosis Early, Cirrhosis Due to Hepatitis B, Cirrhosis Advanced, Cirrhosis Infectious, Cirrhosis Alcoholic, Cirrhosis, Biliary, Cirrhosis Cryptogenic, Cirrhosis Due to Hepatitis C, Cirrhosis Due to Primary Sclerosing Cholangitis
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Study of ART0380 in Patients With Biologically Selected Solid Tumors
NCT05798611
Recruiting
This interventional study will evaluate the efficacy and safety of ART0380 as monotherapy in patients whose tumors have a biology to predict for sensitivity to inhibition of Ataxia-Telangiectasia Mutated and Rad3-related protein kinase (ATR).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: University of California Los Angeles (UCLA), Los Angeles, California
Conditions: Advanced Solid Tumor, Recurrent Endometrial Cancer, Metastatic Cancer
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Bright IDEAS for Pediatric Palliative Care: A Problem-Solving Skills Intervention to Empower Parent Resilience
NCT05899998
Recruiting
The goal of this or clinical trial is to test in the feasibility, acceptability and preliminary efficacy of the bright IDEAS problem solving skills training for parents of children in palliative care. The main questions it aims to answer are: Is bright IDEAS problem solving skills training feasible and acceptable for parents of children referred to pediatric palliative care? Does bright IDEAS reduce psychological distress in parents compared to parents receiving standard palliative care support... Read More
Gender:
All
Ages:
8 years and above
Trial Updated:
01/04/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Psychological Distress, Quality of Life
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A Study to Evaluate EDP 938 Regimens in Children With RSV
NCT04816721
Recruiting
A 2-part study to evaluate the safety, pharmacokinetics and efficacy of EDP-938 in children with RSV infection.
Gender:
All
Ages:
Between 28 days and 36 months
Trial Updated:
01/04/2024
Locations: University of California Los Angeles (UCLA), Los Angeles, California
Conditions: Respiratory Syncytial Virus (RSV)
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A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
NCT05878717
Recruiting
This study investigates the efficacy and safety of belimumab compared to placebo, in addition to standard therapy, for the treatment of participants with systemic sclerosis associated interstitial lung disease (SSc-ILD). The study will evaluate the effect of belimumab treatment on lung function as well as on extra-pulmonary disease manifestations, including skin thickening and general symptoms, such as fatigue, that impact quality of life (QoL).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: GSK Investigational Site, Los Angeles, California +2 locations
Conditions: Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic
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Psychoeducation for Uveal Melanoma
NCT06075589
Recruiting
This clinical trial evaluates a video-based psychoeducational intervention for patients with uveal melanoma. Uveal melanoma (UM) is a rare intraocular cancer. UM patients face an uncertain course of survivorship in terms of their visual acuity, treatment-related side effects, and risk for eventual metastasis of the cancer. Learning about patients' thoughts and reactions to informational resources may better support patients during ocular melanoma survivorship.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Uveal Melanoma
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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
NCT05102019
Recruiting
To demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardial ischemia in the distribution of the left coronary artery and who are deemed unsuitable for revascularization. A non-randomized single-arm will further assess the safety and effectiveness of the Neovasc Reducer System in selected subjects with rever... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Cedars-Sinai, Los Angeles, California
Conditions: Refractory Angina
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Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542
Recruiting
The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Keck School of Medicine of USC, Los Angeles, California +1 locations
Conditions: Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal, Colorectal Cancer, Squamous Cell Carcinoma of the Lung, EGFR Amplification, Epithelial Ovarian Cancer, Pancreas Cancer, Cutaneous Squamous Cell Carcinoma, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Squamous Cell Carcinoma of Head and Neck
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