There are currently 2033 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Benefits of Endoscopic Bariatric Procedures
NCT05514288
Recruiting
This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty [ESG] or transoral outlet reduction [TORe]) as clinically indicated, and subsequent follow up clinic visits for up to one year.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/02/2023
Locations: Liliana Bancila, Los Angeles, California
Conditions: Obesity
Register for Updates
FT819 in Subjects With B-cell Malignancies
NCT04629729
Recruiting
This is a Phase I dose-finding study of FT819 as monotherapy and in combination with IL-2 in subjects with relapsed/refractory B-cell Lymphoma, Chronic Lymphocytic Leukemia and Precursor B-cell Acute Lymphoblastic Leukemia. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: UCLA Ronald Reagan Medical Center, Los Angeles, California
Conditions: Lymphoma, B-Cell, Chronic Lymphocytic Leukemia, Precursor B-Cell Acute Lymphoblastic Leukemia
Register for Updates
Optimization of Prostate Biopsy - Micro-Ultrasound Versus MRI
NCT05220501
Recruiting
OPTIMUM is a study designed to compare the ability of ultra-high resolution transrectal micro-ultrasound (microUS) and multiparametric MRI (mpMRI)/US fusion to guide prostate biopsy.
Gender:
Male
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: UCLA, Los Angeles, California
Conditions: Prostate Cancer
Register for Updates
Pilot Study of Posaconazole in Crohn's Disease
NCT04966585
Recruiting
This trial is designed to evaluate the effects of oral antifungal treatment with posaconazole on active Crohn's disease (CD) activity and the burden of Malassezia spp. in CD patients with the caspase recruitment domain family member 9 (CARD9) S12N risk allele. Further, this project will investigate the hypothesis that the microbial changes induced by antifungal treatment are associated with dampened downstream immune responses in those with a genetic predisposition to developing strong immune re... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
10/31/2023
Locations: Cedars-Sinai Medical Center (CSMC), Los Angeles, California
Conditions: Crohn Disease, CARD9 S12N Risk Allele
Register for Updates
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement
NCT02810704
Recruiting
PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/30/2023
Locations: UCLA, Los Angeles, California
Conditions: Pulmonary Embolism, Venous Thrombosis
Register for Updates
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
NCT04696731
Recruiting
This is a Phase 1 dose escalation study following a 3+3 study design. The purpose of the TRAVERSE study is to assess the safety, efficacy, and cell kinetics of ALLO-316 in adults with advanced or metastatic clear cell renal cell carcinoma after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, and ALLO-647 to define a Phase 2 dose.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/30/2023
Locations: UCLA Medical Center, Los Angeles, California
Conditions: Advanced/Metastatic Clear Cell Renal Cell Carcinoma
Register for Updates
Individual Cerebral Hemodynamic Oxygenation Relationships
NCT04435834
Recruiting
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All el... Read More
Gender:
All
Ages:
1 year and below
Trial Updated:
10/30/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Anesthesia, Anesthesia; Reaction
Register for Updates
Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors
NCT04446351
Recruiting
This first-time-in-human (FTIH) study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of escalating doses of GSK6097608 given as monotherapy and in combination with dostarlimab in participants with advanced solid tumors. In addition, dostarlimab will be given as monotherapy (Arm D); and in combination with belrestotug (Arm E); and with GSK6097608 + belrestotug (Arm F) in Japanese and Chinese participants. The study may asses... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/29/2023
Locations: GSK Investigational Site, Los Angeles, California
Conditions: Neoplasms
Register for Updates
Multicenter Interventional Lymphangioleiomyomatosis (LAM) Early Disease Trial
NCT03150914
Recruiting
This is a study to determine if early, long-term low dose sirolimus is effective for preventing progression to more advanced stages.
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/25/2023
Locations: UCLA, Los Angeles, California
Conditions: LAM, Lymphangioleiomyomatosis
Register for Updates
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
All
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
Register for Updates
VR to Reduce Pain/Anxiety During Painful Procedures
NCT04268901
Recruiting
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries.
Gender:
All
Ages:
Between 7 years and 21 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Phlebotomy, Orthopedics, Radiology, Pain, Anxiety, Virtual Reality, Allergy, Gastroenterology
Register for Updates
Fludarabine and Total Body Irradiation 800 Centigray (cGy) or 1125 cGy For Allogeneic Stem Cell Transplant Using Graft Versus Host Disease Prophylaxis With Post-Transplant Cyclophosphamide and Tacrolimus, Without Mycophenolate Mofetil
NCT05256537
Recruiting
This is a pilot study to evaluate the feasibility, safety and potential benefits of removing one immune suppressive drug called mycophenolate mofetil (MMF) from the standard allogenic stem cell transplant treatment protocol. MMF will be omitted from the transplant regimen in 60 eligible patients with hematologic malignancies. Participants will be followed for up to 2 years post standard of care transplant at Cedars-Sinai.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/25/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Hematologic Neoplasms
Register for Updates