There are currently 1854 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Los Angeles, California +1 locations
Conditions: Neoplasms
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Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
NCT03485794
Recruiting
This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
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FID-007 in Treating Participants With Advanced Solid Tumors
NCT03537690
Recruiting
This phase I trial studies the side effects and best dose of PEOX-based polymer encapsulated paclitaxel FID-007 (FID-007) in treating participants with malignant neoplasms that have spread to other places in the body and do not respond to treatment. FID-007 is a packaged form of the chemotherapy drug paclitaxel, and uses a polyethylozaxoline (PEOX) polymer which may allow the drug to reach deeper into tumors and less into normal cells by being smaller.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: Los Angeles General Medical Center, Los Angeles, California +1 locations
Conditions: Advanced Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm
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Pharmacogenomics of Asparaginase Induced Hepatotoxicity
NCT03568266
Recruiting
This pilot trial studies the impact of genetic information on developing liver damage caused by asparaginase in participants with newly diagnosed acute lymphoblastic leukemia. Testing saliva samples may help doctors find certain genetic markers that may predict whether participants will tolerate asparaginase, which is given as part of clinical care for acute lymphoblastic leukemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Acute Lymphoblastic Leukemia
Register for Updates
Coronary Atherosclerosis T1-Weighted Characterization (CATCH)
NCT03504956
Recruiting
This study proposes to develop an MRI technique named Coronary Atherosclerosis T1-weighed Characterization (CATCH) that will improve the quality and reliability of coronary atherosclerosis evaluation, as well as simplify the scanning process and significantly shorten imaging time compared with conventional imaging methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Coronary Atherosclerosis
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The Role of Virtual Reality During Regional Anesthesia
NCT04163809
Recruiting
In this study, we will analyze the role of virtual reality in acute pain and anxiety management for regional anesthesia in pre-operative patients at Cedars-Sinai Medical Center.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/12/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Anxiety, Pain
Register for Updates
LOWER: Lomitapide Observational Worldwide Evaluation Registry
NCT02135705
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Homozygous Familial Hypercholesterolemia
Register for Updates
First in Human Study of UCT-03-008 in Participants With Advanced Solid Tumors
NCT05103046
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of UCT-03-008 in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: UCLA - JCCC Clinical Research Unit, Los Angeles, California
Conditions: Advanced Solid Tumor
Register for Updates
Assisted Fluid Management (AFM) System and Postoperative Outcome After High-risk Abdominal Surgery
NCT06011187
Recruiting
Goal directed fluid therapy (GDFT) or "Personalized fluid therapy" may benefit high-risk surgical patients but these strategies are infrequently implemented. It has also been shown that without any goal or protocol for fluid resuscitation, large inter- and intra-provider variability exist that have been correlated with poor patient outcomes. Recently, an "Assisted Fluid Management" (AFM) system has been developed to help ease some of the work associated with GDFT protocol implementation. The AF... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: University of California Los Angeles (UCLA), Los Angeles, California
Conditions: Decision Support System, Outcome
Register for Updates
BPH Global Registry
NCT05543200
Recruiting
Benign prostatic hyperplasia (BPH) is one of the most common performed surgical procedures in urology. Over the past few decades there have been an increasing development of newer surgical treatment options. Additionally, the outcome parameters for BPH treatments have been standardized. While data are available for the initial pivotal studies, post-market release data are lacking. Under the umbrella of uCARE, we have started a prospective, ongoing international registry for recording demographic... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Keck Medicine of USC, Los Angeles, California
Conditions: Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Register for Updates
Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV
NCT05154513
Recruiting
IMPAACT 2028 is an observational prospective study to characterize a cohort of early treated children who may participate in future research related to HIV remission or cure. Up to approximately 250 participants will be in the study for approximately seven years. No intervention is provided in the study.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: David Geffen School of Medicine at UCLA (CRS 5112), Los Angeles, California
Conditions: HIV Infection
Register for Updates
Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors
NCT05438420
Recruiting
This study is a phase 1B/2 open-label, study to determine safety and preliminary efficacy of Q702 in combination with pembrolizumab in study subjects with advanced esophageal, gastric/GEJ, hepatocellular, and cervical cancers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Esophageal Cancer, Gastric Cancer, Hepatocellular Cancer, Cervical Cancer
Register for Updates