There are currently 1881 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
iMmune SignAtures and Clinical outComes in AP
NCT05878236
Recruiting
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants wil... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/07/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Acute Pancreatitis
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Prostate Resection After Microwave Ablation (PRAMA)
NCT06128525
Recruiting
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients with prostate cancer. Prostate cancer is the second most common cancer in men and most will never become aggressive. Despite this, most men choose to undergo treatment which may include surgery. Removing the prostate gland and sometimes the lymph nodes (radical prostate... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
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Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
NCT04658628
Recruiting
In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the participants normal clinical care during a 2-year period. This imagining study is completed for research purposes. There is no standard of care imaging for the participants. This study requires two visits in... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/05/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
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Exercise for Brain Regeneration in Epilepsy
NCT05179083
Recruiting
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: University of Southern California Department of Neurosurgery, Los Angeles, California
Conditions: Temporal Lobe Epilepsy
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International CDKL5 Clinical Research Network
NCT05558371
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of California Los Angeles/UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
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Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
NCT06171607
Recruiting
This clinical trial investigates the role of contrast enhanced ultrasound (CEUS) in identifying cystic breast masses as benign or malignant. Ultrasound is a diagnostic imaging test that uses sound waves to make pictures of the body without using radiation (x-rays). Ultrasounds are widely used to diagnose many diseases in the body. This trial may help researchers learn if using CEUS will help in determining whether or not an ultrasound guided biopsy is necessary.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California +1 locations
Conditions: Breast Carcinoma
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Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
NCT04773392
Recruiting
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient survival as compared to a combination of twice-daily immediate release tacrolimus and mycophenolate mofetil/mycophenolic acid.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/04/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Kidney Transplantation, Kidney Transplant Rejection
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The K-Map Study, Global Prevalence of KC
NCT03115710
Recruiting
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss. The overall goal of this study is to assess the prevalence of keratoconus (KC) in children and adolescents in various regions of the world based on modern tomographic imaging methods, and to verify whether the occurrence rates reported from literature should be corrected. Our hypothesis... Read More
Gender:
ALL
Ages:
Between 6 years and 23 years
Trial Updated:
12/04/2023
Locations: USC Roski Eye Institute, Los Angeles, California
Conditions: Keratoconus
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Peer Support for Patients With Diabetic Foot Ulcers
NCT06004219
Recruiting
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation are unevenly patterned in terms of racial/ethnicity, socioeconomic status, health insurance, and geographic area. The project will identify opportunities to reduce health disparities among economically marginalized patients regarding DFU outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot, Diabetes Complications, Peripheral Neuropathy
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Adolescent Acts of Kindness Intervention With Reflection
NCT05267132
Recruiting
Adolescents will complete a 4-week intervention, during which they will either complete a kind act for others, complete a kind act for others with a reflection component, or report their daily activities three days per week. Psychological measures will be indexed before and after the intervention.
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
11/29/2023
Locations: Adolescent Development Lab, Los Angeles, California
Conditions: Mental Health Wellness 1
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A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
NCT04951219
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Ruane Clinical Research Group, Los Angeles, California +2 locations
Conditions: Non-Alcoholic Fatty Liver Disease
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Evaluation of SPH3127 in Patients With Mild-to-Moderate Ulcerative Colitis
NCT05019742
Recruiting
SPH3127-US-01 is a multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, pharmacokinetics, and preliminary efficacy of SPH3127 for the treatment of mild-to-moderate ulcerative colitis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/24/2023
Locations: Southern California Research Institute Medical Group, Inc., Los Angeles, California
Conditions: Ulcerative Colitis
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