There are currently 2033 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
NCT06138639
Recruiting
This is a multicenter, open-label, non-randomized study to investigate the safety, tolerability, and efficacy of a single IV infusion of SGT-003 in participants with Duchenne muscular dystrophy. There will be 2 cohorts in this study, dosed sequentially. Cohort 1 will include participants 4 to <6 years of age, inclusive. Cohort 2 will only be opened after dosing and monitoring a subset of participants in Cohort 1. Cohort 2 will include participants 6 to <8 years of age, inclusive. All participant... Read More
Gender:
Male
Ages:
Between 4 years and 7 years
Trial Updated:
03/27/2024
Locations: University of California, Los Angeles Medical Center, Los Angeles, California
Conditions: Duchenne Muscular Dystrophy
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Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
NCT03858205
Recruiting
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiatio... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Los Angeles General Medical Center, Los Angeles, California +2 locations
Conditions: Bone Pain, Metastatic Malignant Neoplasm in the Bone, Plasma Cell Myeloma
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To Assess the Effect of SCD-044 Treatment on Moderate to Severe Plaque Psoriasis
NCT04566666
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in subjects with moderate to severe plaque psoriasis.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Site # 13, Los Angeles, California
Conditions: Moderate to Severe Plaque Psoriasis
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Short-term Fasting Prior to PD-1/PD-L1 Inhibitor Therapy for of Advanced or Metastatic Skin Malignancy
NCT04387084
Recruiting
This trial studies the side effects of short-term fasting in patients with skin malignancy that has spread to other places in the body (advanced or metastatic) treated with a PD-L1 or PD-1 inhibitor. Immunotherapy with monoclonal antibodies, such as pembrolizumab, nivolumab, cemiplimab, avelumab, atezolizumab, or durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Undergoing short-term fasting prior to treatment w... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Los Angeles General Medical Center, Los Angeles, California +1 locations
Conditions: Advanced Malignant Skin Neoplasm, Metastatic Malignant Skin Neoplasm
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A Study of E7386 in Combination With Other Anticancer Drug in Participants With Solid Tumor
NCT04008797
Recruiting
The primary objective of this study is to assess the safety and tolerability and to determine the recommended Phase 2 dose (RP2D) of E7386 in combination with other anticancer drug(s).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms
Register for Updates
Phase 2 Study of EDG-5506 in Children and Adolescents With Duchenne Muscular Dystrophy Previously Treated With Gene Therapy (FOX)
NCT06100887
Recruiting
The FOX study is a 2-part, multicenter, Phase 2 study of safety, pharmacokinetics, and biomarkers in children and adolescents with Duchenne muscular dystrophy previously treated with gene therapy including a randomized, double-blind, placebo-controlled Part A, followed by an open-label part B.
Gender:
Male
Ages:
Between 6 years and 14 years
Trial Updated:
03/26/2024
Locations: UCLA Medical Center, Los Angeles, California
Conditions: Duchenne Muscular Dystrophy
Register for Updates
Breast Cancer Survivorship Biorepository
NCT05786664
Recruiting
This study collects blood samples as well as clinical and self-report data from stage I-III breast cancer survivors to create a biorepository for future use. The creation of this biorepository will allow for future research into links between individual, molecular, and genomic signatures and cancer outcomes.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Invasive Breast Carcinoma
Register for Updates
OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD)
NCT04757610
Recruiting
A 2-year, phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.
Gender:
All
Ages:
50 years and above
Trial Updated:
03/26/2024
Locations: ShORe Investigational Site, Los Angeles, California
Conditions: Neovascular Age-related Macular Degeneration
Register for Updates
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
NCT06218381
Recruiting
The goal of this clinical trial is to develop a new behavioral treatment for U.S. combat veterans with post-traumatic stress disorder (PTSD), very brief exposure to combat-related stimuli. The main questions it aims to answer are: How does Very Brief Exposure (combat images and control everyday images) and Visible Exposure to combat stimuli affect brain activity and subjective fear ratings? To what extent are participants aware of the stimuli presented and tolerating the exposures? All partici... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
03/25/2024
Locations: Brain Imaging Lab, Los Angeles, California
Conditions: Post Traumatic Stress Disorder
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Evaluation of Pharmacokinetics, Pharmacodynamics, Efficacy, Safety, and Immunogenicity of Ravulizumab Administered Intravenously in Pediatric Participants With Generalized Myasthenia Gravis (gMG)
NCT05644561
Recruiting
The primary purpose of this study is to characterize the pharmacokinetics and pharmacodynamics of treatment with ravulizumab intravenous infusion in pediatric participants with gMG.
Gender:
All
Ages:
All
Trial Updated:
03/25/2024
Locations: Research Site, Los Angeles, California
Conditions: Generalized Myasthenia Gravis, gMG
Register for Updates
Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
NCT05948657
Recruiting
This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.
Gender:
Male
Ages:
Between 18 years and 90 years
Trial Updated:
03/25/2024
Locations: UCLA, Los Angeles, California
Conditions: Prostate Cancer
Register for Updates
SPIROMICS Study of Early COPD Progression (SOURCE)
NCT05033990
Recruiting
This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals. The study has three main goals: To use CT scan imaging to identify which smokers will develop COPD. To identify biomarkers predictive of smokers that will develop COPD. To determine if sputum (phlegm) can be analyzed to predict which smokers will develop COPD. Procedures (methods): All participants will undergo study related qu... Read More
Gender:
All
Ages:
Between 30 years and 55 years
Trial Updated:
03/25/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: COPD, Early-Onset
Register for Updates