There are currently 23 active clinical trials seeking participants for Atherosclerosis research studies. The states with the highest number of trials for Atherosclerosis participants are California, Florida, Texas and New York.
Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
NCT04496947
Recruiting
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.
Gender:
All
Ages:
Between 30 years and 65 years
Trial Updated:
01/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis, Stress, Inflammation
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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
NCT02915198
Recruiting
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in patients who have pre-diabetes and heart or blood vessel problems.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona +39 locations
Conditions: Prediabetic State, Atherosclerosis, Metformin
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The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
NCT04505865
Recruiting
This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial stress.
Gender:
All
Ages:
Between 45 years and 65 years
Trial Updated:
12/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis, Stress, Inflammation
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Advancing Postmenopausal Preventive Therapy
NCT04103476
Recruiting
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical atherosclerosis and cognitive decline in 360 healthy postmenopausal women.
Gender:
Female
Ages:
Between 45 years and 59 years
Trial Updated:
11/21/2023
Locations: University of Southern California Atherosclerosis Research Unit, Los Angeles, California
Conditions: Atherosclerosis, Cognitive Decline
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Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
NCT04523194
Recruiting
The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.
Gender:
All
Ages:
All
Trial Updated:
10/19/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Atherosclerosis
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Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
NCT05867381
Recruiting
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Gender:
All
Ages:
Between 65 years and 84 years
Trial Updated:
09/22/2023
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Atherosclerosis
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PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
NCT05994014
Recruiting
Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/08/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Coronary Artery Disease, Atherosclerosis, Coronary Atherosclerosis of Native Coronary Artery
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Comparing Perclose to Statseal in Conjunction With Perclose in Femoral 6 French Arteriotomy Closure
NCT05468957
Recruiting
The purpose of this clinical study is to compare how well two different devices for achieving hemostasis perform in patients undergoing transfemoral procedures with 6 French Access. Both devices are approved by the FDA for this use, and have already been used by clinicians on patients undergoing transfemoral procedures. It is believed that the use of both devices in combination compared to the Perclose alone will shorten the time that it takes to 'seal' the artery, resulting in a shorter period... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: UCLA Ronald Reagen, Los Angeles, California +1 locations
Conditions: Arterial Occlusion, Cardiovascular Diseases, Atherosclerosis, Hematoma
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Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
NCT05488431
Recruiting
This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusett... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
06/28/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
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The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
NCT04089943
Recruiting
MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.
Gender:
All
Ages:
30 years and above
Trial Updated:
02/03/2023
Locations: University of Texas Health Science Center at San Antonio, San Antonio, Texas +1 locations
Conditions: Peripheral Arterial Disease, Vascular Diseases, Peripheral, Arterial Occlusive Diseases, Atherosclerosis
Register for Updates
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
NCT02265250
Recruiting
Cardiovascular disease (CVD) remains the leading cause of death in the United States, and improved CVD risk assessment is needed for personalized medicine. Atherosclerosis measures including plaque volume and adverse plaque features have prognostic value. Novel techniques have been developed for assessing carotid, coronary, and femoral atherosclerosis using magnetic resonance imaging (MRI) methods that are rapid and reproducible, have improved spatial resolution, and do not require contrast medi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/06/2020
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cardiovascular Disease, Atherosclerosis
Register for Updates