There are currently 23 active clinical trials seeking participants for Atherosclerosis research studies. The states with the highest number of trials for Atherosclerosis participants are California, Florida, Texas and New York.
The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
NCT04505865
Recruiting
This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial stress.
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
12/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis, Stress, Inflammation
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Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
NCT04523194
Recruiting
The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.
Gender:
ALL
Ages:
All
Trial Updated:
11/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Atherosclerosis
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Comparing Perclose to Statseal in Conjunction with Perclose in Femoral 6 French Arteriotomy Closure
NCT05468957
Recruiting
The purpose of this clinical study is to compare how well two different devices for achieving hemostasis perform in patients undergoing transfemoral procedures with 6 French Access. Both devices are approved by the FDA for this use, and have already been used by clinicians on patients undergoing transfemoral procedures. It is believed that the use of both devices in combination compared to the Perclose alone will shorten the time that it takes to 'seal' the artery, resulting in a shorter period... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: UCLA Ronald Reagen, Los Angeles, California +1 locations
Conditions: Arterial Occlusion, Cardiovascular Diseases, Atherosclerosis, Hematoma
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Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
NCT05708859
Recruiting
A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atherosclerosis.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
10/10/2024
Locations: Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute), Torrance, California
Conditions: Type II Diabetes, Atherosclerosis
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PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
NCT05994014
Recruiting
Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Coronary Artery Disease, Atherosclerosis, Coronary Atherosclerosis of Native Coronary Artery
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Text Education About Cardiovascular Health and HIV (TEACH-HIV)
NCT05642858
Recruiting
The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).
Gender:
All
Ages:
40 years and above
Trial Updated:
06/17/2024
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California +1 locations
Conditions: HIV, Human Immunodeficiency Virus, Cardiovascular Diseases, Atherosclerosis
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IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815
Recruiting
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, util... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Northwest Medical Center, Tucson, Arizona +60 locations
Conditions: Atherosclerosis
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Immunomodulatory Effects of PCSK9 Inhibition
NCT05720156
Recruiting
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also have pleiotropic effects on inflammation. The immunomodulatory effects of these medications are relevant to ASCVD risk reduction given that inflammation plays a central role in atherosclerotic plaque formation (atherogenesis) and influences the development of vulnerable pla... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/08/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation, Vascular Diseases, Vascular Disease, Peripheral, Vascular Calcification, High Cholesterol/Hyperlipidemia, Heart Diseases, Heart Attack, Stroke, Cerebrovascular Accident, Carotid Artery Diseases, Carotid Atherosclerosis, Transient Ischemic Attack
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Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
NCT05867381
Recruiting
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Gender:
All
Ages:
Between 65 years and 84 years
Trial Updated:
09/22/2023
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Atherosclerosis
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Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
NCT05488431
Recruiting
This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusett... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
06/28/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
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Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
NCT02265250
Recruiting
Cardiovascular disease (CVD) remains the leading cause of death in the United States, and improved CVD risk assessment is needed for personalized medicine. Atherosclerosis measures including plaque volume and adverse plaque features have prognostic value. Novel techniques have been developed for assessing carotid, coronary, and femoral atherosclerosis using magnetic resonance imaging (MRI) methods that are rapid and reproducible, have improved spatial resolution, and do not require contrast medi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/06/2020
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cardiovascular Disease, Atherosclerosis
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