There are currently 42 active clinical trials seeking participants for Brain Metastases research studies. The states with the highest number of trials for Brain Metastases participants are Michigan, California, New York and North Carolina.
Phase I Study of Fractionated Stereotactic Radiation Therapy
Recruiting
There is a lack of prospective trial data and consensus guidelines describing the use of Fractionated Stereotactic Radiation Therapy (FSRT) in the treatment of brain metastases. There has been no prospective dose escalation study performed to date to determine the maximum tolerated dose (MTD) in patients treated with FSRT. Prescription doses in the series described above ranged from 18 Gy to 42 Gy, delivered in 3 to 12 fractions. The results of this study will be used to plan future Phase II/III... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Brain Metastases
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Recruiting
This is a pilot imaging study in participants treated with stereotactic radiosurgery (SRS) to treat brain metastasis. The purpose of this study is to see whether 18F-Fluciclovine positron emission tomography (PET) can be used as a biomarker to measure response or progression of brain metastasis after SRS.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/16/2024
Locations: Miami Cancer Institute, Miami, Florida
Conditions: Brain Metastases, Brain Metastases, Adult, Brain Cancer
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Recruiting
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy. A dose of 30 Gy in 10 fractions will be delivered using the PRDR technique.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/08/2024
Locations: Froedtert Hospital & the Medical College of Wisconsin, Milwaukee, Wisconsin +1 locations
Conditions: Brain Metastases
Neurocognitive Decline in Patients With Brain Metastases
Recruiting
The phase I component of the study is to identify maximal tolerated dose (MTD). The phase II is to evaluate neurocognitive decline.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/08/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Brain Metastases
NTS-WBRT in Brain Metastases
Recruiting
This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT). This research study involves: NTS-WBRT (normal tissue sparing whole brain radiation therapy) Memantine standard of care drug
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Brain Metastases
HyperArc Registry Study
Recruiting
The HyperArc registry is designed to collect data from which the efficacy of the HyperArc procedure can be assessed and compared to alternative treatments.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/12/2023
Locations: University of Alabama, Birmingham, Alabama +4 locations
Conditions: Brain Metastases, CNS Neoplasm, CNS Disorder, Intracranial