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Carcinoma, Non-Small-Cell Lung Clinical Trials
A listing of 40 Carcinoma, Non-Small-Cell Lung clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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There are currently 40 active clinical trials seeking participants for Carcinoma, Non-Small-Cell Lung research studies. The states with the highest number of trials for Carcinoma, Non-Small-Cell Lung participants are California, Texas, Florida and New York.
Featured Trial
Healthy Participants Needed (Colonoscopy + Cancer Screening)
Recruiting
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Conditions:
Healthy
Healthy Volunteers
Healthy Subjects
Healthy Volunteer
Healthy Participants
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Recruiting
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Featured Trial
Stroke Clinical Study
Recruiting
A clinical study for people that suffer with Stroke
Conditions:
Stroke
Featured Trial
Chronic Kidney Disease (CKD) Clinical Study
Recruiting
A clinical study for people that suffer with Chronic Kidney Disease (CKD)
Conditions:
Chronic Kidney Disease (CKD)
A Study of FWD1509 in Adults With Non-Small Cell Lung Cancer
Recruiting
The purpose of this study is to characterize the safety and tolerability of FWD1509 MsOH in advanced NSCLC patients and establish the maximum tolerable dose (MTD), recommended phase 2 dose (RP2D) in advanced NSCLC patients.
The purpose of this study is to characterize the safety and tolerability of FWD1509 MsOH in advanced NSCLC patients and establish the maximum tolerable dose (MTD), recommended phase 2 dose (RP2D) in advanced NSCLC patients. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/20/2022
Locations: Gabrail Cancer Center, Canton, Ohio +1 locations
Gabrail Cancer Center, Canton, Ohio
MD Anderson Cancer Center, Houston, Texas
Conditions: Carcinoma, Non-Small-Cell Lung
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Recruiting
The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.
The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +346 locations
University of Alabama at Birmingham, Birmingham, Alabama
Clearview Cancer Institute, Huntsville, Alabama
The University of Arizona Cancer Center - North Campus, Tucson, Arizona
Highlands Oncology Group, Springdale, Arkansas
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Profound Research LLC, Oceanside, California
University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange, California
Stanford Cancer Center, Palo Alto, California
Kaiser Permanente San Diego Mission Road, San Diego, California
BASS Cancer Center, Walnut Creek, California
Hartford Hospital (HH), Hartford, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
Boca Raton Regional Hospital, Boca Raton, Florida
Florida Cancer Specialists - South, Fort Myers, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida
Florida Cancer Specialists North, Saint Petersburg, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Moffitt Cancer Center, Tampa, Florida
Florida Cancer Specialists East, West Palm Beach, Florida
University of Illinois at Chicago, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
Captain James A. Lovell Federal Health Care Center, North Chicago, Illinois
Springfield Clinic Main Campus, Springfield, Illinois
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana
Franciscan Health, Indianapolis, Indiana
Baptist Health Lexington, Lexington, Kentucky
Baptist Health Hamburg, Lexington, Kentucky
CHI Saint Joseph Cancer Center - East, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Ochsner Health Ochsner Cancer Center - Baton Rouge, Baton Rouge, Louisiana
Ochsner Clinic Foundation, New Orleans, Louisiana
New England Cancer Specialists, Westbrook, Maine
University of Maryland, Baltimore, Maryland
Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Reliant Medical Group, Worcester, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Missouri Baptist Medical Center, Saint Louis, Missouri
Jefferson Health - Cherry Hill, Cherry Hill, New Jersey
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Sidney Kimmel Cancer Center - Washington Township, Sewell, New Jersey
Columbia University Irving Medical Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Northport VA Medical Center, Northport, New York
Cleveland Clinic, Cleveland, Ohio
Providence Portland Medical Center, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania
Jefferson Hospital Northeast, Philadelphia, Pennsylvania
AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Sarah Cannon Research Institute, Nashville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
The Center for Cancer and Blood Disorders, Fort Worth, Texas
Houston Methodist Hospital, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
USO - Texas Oncology - San Antonio, San Antonio, Texas
USO - Texas Oncology Gulf Coast, Sugar Land, Texas
USO - US Oncology Research Network, The Woodlands, Texas
The University of Vermont Medical Center Inc., Burlington, Vermont
University of Virginia Health System, Charlottesville, Virginia
VCU Health Adult Outpatient Pavillion, Richmond, Virginia
Swedish Cancer Institute - Edmonds, Edmonds, Washington
Swedish Medical Center, Seattle, Washington
Cancer Care Northwest - Vercler, Spokane Valley, Washington
Northwest Cancer Specialists PC, Vancouver, Washington
University Hospital and UW Health Clinics, Madison, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Icon Cancer Centre Wesley, Auchenflower, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Austin Health, Heidelberg, Not set
ICON Cancer Centre - Kurralta Park, Kurralta Park, Not set
Tamworth Hospital, North Tamworth, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Goulburn Valley Health, Shepparton, Not set
Latrobe Regional Health, Traralgon, Not set
Medizinische Universität Graz, Graz, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Klinik Floridsdorf, Wien, Not set
CHIREC - site delta, Auderghem, Not set
Antwerp University Hospital, Edegem, Not set
UZ Leuven, Leuven, Not set
AZ Delta vzw, Roeselare, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, Not set
CTO - Centro de Tratamento Oncológico, Belem, Not set
Oncocentro de Minas Gerais, Belo Horizonte, Not set
Hospital Tacchini, Bento Gonçalves, Not set
Centro de Pesquisa Sao Lucas, Campinas, Not set
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza, Not set
Hospital de Cancer de Londrina, Londrina, Not set
Liga Norte Riograndense Contra o Câncer, Natal, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set
Hospital Santa Catarina - Paulista, São Paulo, Not set
Centro Paulista de Oncologia Clínica, São Paulo, Not set
K2 Oncology, Providencia, Not set
FALP, Santiago, Not set
Centro de Oncología de Precisión, Santiago, Not set
Bradfordhill, Santiago, Not set
Anyang Cancer Hospital, Anyang, Not set
Cancer Hospital Chinese Academy of Medical Science, Beijing, Not set
China-Japan Friendship Hospital, Beijing, Not set
Peking University People's Hospital, Beijing, Not set
Beijing Cancer hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Xiangya Hospital Central South University, Changsha, Not set
Xiangya Hospital Central South University, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
The Third People's Hospital of Chengdu (CDTPH), Chengdu, Not set
Sichuan Cancer hospital, Chengdu, Not set
The Second Affiliated Hospital Chongqing Medical University, Chongqing, Not set
The First People's Hospital of Foshan, Foshan, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Zhejiang Provincial People's Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
The Second Affiliated hospital of Zhejiang University school of medicine, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
Shandong Cancer Hospital, Jinan, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
Liuzhou People's Hospital, Liuzhou, Not set
The First Affiliated Hospital of Henan University of Science &Technology, Luoyang, Not set
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Not set
The Second People's Hospital of Neijiang, Neijiang, Not set
Shanghai Chest Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Cancer Hospital of Shantou University Medical College, Shantou, Not set
ShenZhen People's Hospital, Shenzhen, Not set
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Zhongshan Peoples Hospital, Zhongshan, Not set
ZhuZhou Central Hospital, Zhuzhou, Not set
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Not set
Fakultni nemocnice Bulovka, Prague, Not set
Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Not set
Chu Grenoble Alpes, La Tronche, Not set
Centre Leon Berard, Lyon Cedex08, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Centre Antoine-Lacassagne, Nice, Not set
Groupe hospitalier Paris saint Joseph, Paris, Not set
Hôpital Européen Georges Pompidou, Paris, Not set
Institut Curie, Paris, Not set
CHU Bordeaux Haut-Leveque, Pessac, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
CHU de Toulouse - Hopital Larrey, Toulouse, Not set
Hôpital Robert Schuman, Vantoux, Not set
Gustave Roussy, Villejuif, Not set
Vivantes Klinikum im Friedrichshain - Landsberger Allee, Berlin, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
DRK Kliniken Berlin Mitte, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
MV-Zentrum für Onkologie und Hämatologie, Cologne, Not set
Onkologiezentrum Donauwörth, Donauwörth, Not set
Florence-Nightingale-Krankenhaus, Düsseldorf, Not set
HELIOS Klinikum Erfurt, Erfurt, Not set
Asklepios Fachkliniken München-Gauting, Gauting, Not set
Franziskus-Hospital Harderberg, Georgsmarienhütte, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle-Dölau, Halle, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Evangelisches Krankenhaus Herne - Eickel, Herne, Not set
Klinikum Köln-Merheim, Köln, Not set
St. Elisabeth-Krankenhaus Leipzig, Leipzig, Not set
Klinikum Nürnberg Nord, Nürnberg, Not set
Robert Bosch Krankenhaus GmbH, Stuttgart, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Agios Savvas Regional Cancer Hospital, Athens, Not set
Errikos Dunant Hospital Center, Athens, Not set
Thoracic General Hospital of Athens "I Sotiria", Athens, Not set
University General Hospital of Heraklion, Heraklion, Not set
University General Hospital of Larissa, Larissa, Not set
University Hospital of Patras, Patras, Not set
Agios Loukas Clinic, Thessaloniki, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
Országos Onkológiai Intézet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Not set
Hemato Oncology Clinic, Ahmedabad, Not set
Galaxy Superspeciality Hospital, Aurangabad, Not set
Rajiv Gandhi Government General Hospital, Chennai, Not set
Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Not set
Thangam Cancer Center - Namakkal, Namakkal, Not set
Savera Cancer & Multi Speciality Hospital, Patna, Not set
Deenanath Mangeshkar Hospital & Research Centre, Pune, Not set
Medipoint Hospitals Pvt. Ltd., Pune, Not set
Malabar Cancer Centre - Thalassery, Thalassery, Not set
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Not set
Pacific Medical College & Hospital, Udaipur, Not set
Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Not set
Rambam Health Care Campus, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Sheba Medical Center, Ramat Gan, Not set
Instituto Tumori Giovanni Paolo II, Bari, Not set
Policlinico "G. Rodolico", Catania, Not set
Ospedale San Martino, Genova, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
ASST Grande Ospedale Metropolitano Niguarda, Milan, Not set
Ospedale San Gerardo-ASST Monza, Monza, Not set
Azienda Ospedaliera Dei Colli, Naples, Not set
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano, Not set
Istituto Nazionale Tumori Regina Elena, Rome, Not set
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Kyushu University Hospital, Fukuoka, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of JFCR, Koto, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
Miyagi Cancer Center, Natori, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
NHO Kinki Chuo Chest Medical Center, Sakai, Not set
Hokkaido University Hospital, Sapporo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Not set
Kanagawa cancer center, Yokohama, Not set
Tottori University Hospital, Yonago, Not set
The Catholic University of Korea, Incheon St. Mary's Hospital, Bupyeong-gu, Not set
Pusan National University Hospital, Busan, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Keimyung University Dongsan Hospital, Daegu, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Not set
Yeungnam Univeristy Medical Center, Nam-gu, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Konkuk University Medical Center, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, Not set
Amsterdam UMC, locatie VUmc, Amsterdam, Not set
Amphia Ziekenhuis, locatie Breda Molengracht, Breda, Not set
Ziekenhuis St. Jansdal, Harderwijk, Not set
ETZ Elisabeth, Tilburg, Not set
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Isala, locatie Zwolle, Zwolle, Not set
Sorlandet Sykehus Arendal, Arendal, Not set
Haukeland Universitetssjukehus, Bergen, Not set
Drammen Sykehus, Vestre Viken HF, Drammen, Not set
Sykehuset Innlandet HF Gjøvik, Gjøvik, Not set
Oslo universitetssykehus, Radiumhospitalet, Oslo, Not set
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznan, Not set
One Day Med, Szczecin, Not set
Centro Hospitalar E Universitário De Coimbra, Coimbra, Not set
Hospital da Luz Lisboa, Lisboa, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Lotus-Med, Bucharest, Not set
SC Memorial Healthcare International SRL, Bucharest, Not set
Institutul Oncologic, Cluj, Not set
Ovidius Clinical Hospital OCH, Ovidiu, Not set
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Not set
Univerzitná nemocnica Bratislava - Nemocnica Ružinov, Bratislava, Not set
Vychodoslovensky Onkologicky ustav a.s., Kosice, Not set
Hospital Infanta Cristina, Badajoz, Not set
Parc de Salut Mar - Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, Not set
Hospital Jerez de la Frontera, Jerez de la Frontera, Not set
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitari Son Espases, Palma, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Clinico de Valencia, Valencia, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Sahlgrenska Universitetssjukhuset Östra, Göteborg, Not set
Kantonsspital Baden, Baden, Not set
HFR Fribourg - Hôpital Cantonal, Fribourg, Not set
Changhua Christian Hospital, Changhua County, Not set
Buddhist Dalin Tzu Chi General Hospital, Chiayi, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Hualien Tzu Chi Medical Center, Hualien City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
E-Da hospital, Kaohsiung, Not set
Far Eastern Memorial Hospital, New Taipei City, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Medical Center, Tainan City, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center (NTUCC), Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
Baskent University Dr. Turgut Noyan Research and Training Center, Adana, Not set
Adana City Hospital, Adana, Not set
Sakarya University School of Medicine, Adapazari, Not set
Antalya Egitim ve Arastırma Hastanesi, Antalya, Not set
Trakya University, Edirne, Not set
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep, Not set
İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, Not set
Izmir Atatürk Training and Research Hospital, Izmir, Not set
Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Pendik, Not set
Samsun Medical Park Hastanesi, Samsun, Not set
Heartlands Hospital, Birmingham, Not set
University Hospitals Sussex NHS Foundation Trust, East Sussex, Not set
Huddersfield Royal Infirmary, Huddersfield, Not set
Royal Marsden Hospital (Sutton), London, Not set
Royal Marsden Hospital (Chelsea), London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Torbay Hospital, Torquay, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Recruiting
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +427 locations
Clearview Cancer Institute, Huntsville, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Banner University Medical Center Phoenix, Phoenix, Arizona
The University of Arizona Cancer Center - North Campus, Tucson, Arizona
Highlands Oncology Group, Springdale, Arkansas
Cedars-Sinai Medical Center, Los Angeles, California
Mercy Cancer Center, Merced, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
BASS Cancer Center, Walnut Creek, California
USO - Rocky Mountain Cancer Centers, Lone Tree, Colorado
Yale University School of Medicine, New Haven, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
Millennium Oncology Research Clinic, Hollywood, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala, Ocala, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
University Cancer & Blood Center, LLC, Athens, Georgia
Emory University School of Medicine- Grady Campus, Atlanta, Georgia
Winship Cancer Institute, Emory University, Atlanta, Georgia
University of Illinois at Chicago, Chicago, Illinois
University of Chicago Hospital, Chicago, Illinois
Springfield Clinic Main Campus, Springfield, Illinois
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Franciscan Health, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
CHI Saint Joseph Cancer Center - East, Lexington, Kentucky
University of Kentucky Chandler Medical Center, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
USO - Maryland Oncology Hematology, Annapolis, Maryland
Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Boston Medical Center, Boston, Massachusetts
Lahey Hospital & Medical Center, Burlington, Massachusetts
University of Michigan, Ann Arbor, Michigan
Karmanos Cancer Institute, Detroit, Michigan
The Cancer & Hematology Centers, Grand Rapids, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota
HealthPartners Cancer Research Center, Saint Paul, Minnesota
North Mississippi Hematology and Oncology Associates, Tupelo, Mississippi
Oncology Hematology Associates, Springfield, Missouri
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
The Valley Hospital, Inc., Paramus, New Jersey
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Maimonides Cancer Center, Brooklyn, New York
Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York
Laura and Isaac Perlmutter Cancer Center, New York, New York
Manhattan Eye, Ear and Throat Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Clinical Research Alliance, Westbury, New York
University of North Carolina Medical Center, Chapel Hill, North Carolina
Duke Cancer Institute, Durham, North Carolina
UNC REX Cancer Center, Raleigh, North Carolina
USO - Oncology Hematology Care, Cincinnati, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio
USO - Oncology Associates of Oregon, Eugene, Oregon
Asante Rogue Regional Medical Center, Medford, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon
USO - Alliance Cancer Specialists, PC, Horsham, Pennsylvania
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute, Greenville, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Memorial Hospital-Memphis, Memphis, Tennessee
Tennessee Oncology, Nashville, Tennessee
USO - US Oncology Research Network, Nashville, Tennessee
USO - Texas Oncology, Austin, Texas
William Beaumont Army Medical Center, Fort Bliss, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
Houston Methodist Hospital, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
USO - Texas Oncology, Webster, Texas
The University of Vermont Medical Center Inc., Burlington, Vermont
University of Virginia Health System, Charlottesville, Virginia
USO - Virginia Cancer Specialists, Fairfax, Virginia
VCU Health Adult Outpatient Pavillion, Richmond, Virginia
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
Swedish Medical Center, Seattle, Washington
VA Puget Sound Health Care System, Seattle, Washington
USO - Northwest Cancer Specialists, Vancouver, Washington
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical, Madison, Wisconsin
Royal Adelaide Hospital, Adelaide, Not set
Icon Cancer Centre Wesley, Auchenflower, Not set
Ballarat Health Services, Ballarat Central, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Gosford Hospital, Gosford, Not set
Mackay Base Hospital, Mackay, Not set
St Vincent's Hospital, Melbourne, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Goulburn Valley Health, Shepparton, Not set
Gold Coast University Hospital, Southport, Not set
The Townsville Hospital, Townsville, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Klinik Floridsdorf, Wien, Not set
ZNA Middelheim, Antwerp, Not set
CHIREC - site delta, Auderghem, Not set
AZ Sint-Jan Brugge-Oostende AV, Brugge, Not set
UZ Gent, Gent, Not set
AZ Groeninge Campus Kennedylaan, Kortrijk, Not set
UZ Leuven, Leuven, Not set
AZ Sint-Maarten, Mechelen, Not set
Clinique Saint Pierre, Ottignies, Not set
AZ Glorieux Ronse, Ronse, Not set
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, Not set
Oncocentro de Minas Gerais, Belo Horizonte, Not set
Hospital Tacchini, Bento Gonçalves, Not set
Hospital São Domingos, Bequimao, Not set
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul, Brasilia, Not set
Hospital Universitário Evangélico Mackenzie, Curitiba, Not set
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza, Not set
ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijui, Not set
Hospital Brasilia, Lago sul, Not set
Hospital de Cancer de Londrina, Londrina, Not set
Liga Norte Riograndense Contra o Câncer, Natal, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Oncominas, Pouso Alegre, Not set
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, Not set
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, Not set
Clinica Amo - Rio Vermelho, Salvador, Not set
Faculdade de Medicina do ABC, Santo André, Not set
Hospital Sírio Libanês, Sao Paulo, Not set
Hospital BP, Sao Paulo, Not set
Hospital Paulistano, Sao Paulo, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
COE Ensino e Pesquisa, São José dos Campos, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set
Hospital Santa Catarina - Paulista, São Paulo, Not set
Centro Paulista de Oncologia Clínica, São Paulo, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo, São Paulo, Not set
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T, São Paulo, Not set
CEDOES, Vitória, Not set
BC Cancer Abbotsford, Abbotsford, Not set
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Not set
BC Cancer Vancouver, Vancouver, Not set
Cancer Hospital Chinese Academy of Medical Science, Beijing, Not set
Beijing Cancer hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
The First People's Hospital of Changzhou, Changzhou, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
The Third People's Hospital of Chengdu (CDTPH), Chengdu, Not set
Sichuan Cancer hospital, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
Shandong Cancer Hospital, Jinan, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
LinYi Cancer Hospital, Linyi, Not set
Liuzhou People's Hospital, Liuzhou, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Nanjing First Hospital, Nanjing, Not set
Nantong Tumor Hospital, Nantong, Not set
Hwa Mei Hospital University of Chinese Academy of Sciences, Ningbo, Not set
Shanghai Chest Hospital, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Not set
Xinjiang Medical University Cancer Hospital - Urumqi, Urumqi, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Wuhan Union Hospital, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wannan Medical College Yijishan Hospital, Wuhu, Not set
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xiangyang, Not set
Yichang Central People's Hospital, Yichang, Not set
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Not set
ZhuZhou Central Hospital, Zhuzhou, Not set
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Not set
Fakultni nemocnice Bulovka, Prague, Not set
Roskilde University Hospital, Roskilde, Not set
Sainte Catherine Institut du Cancer Avignon Provence, Avignon, Not set
Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Not set
CHU Lille - Institut Coeur Poumon, Lille Cedex, Not set
Centre Leon Berard, Lyon Cedex08, Not set
Centre Antoine-Lacassagne, Nice, Not set
Institut Curie, Paris, Not set
CHU Bordeaux Haut-Leveque, Pessac, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
Nouvel Hôpital Civil (NHC), Strasbourg, Not set
Hôpital Foch, Suresnes, Not set
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon, Not set
CHU de Toulouse - Hopital Larrey, Toulouse, Not set
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Not set
Hôpital Robert Schuman, Vantoux, Not set
Gustave Roussy, Villejuif, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Charité Campus Virchow-Klinikum, Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
MV-Zentrum für Onkologie und Hämatologie, Cologne, Not set
Onkologiezentrum Donauwörth, Donauwörth, Not set
HELIOS Klinikum Erfurt, Erfurt, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
Asklepios Fachkliniken München-Gauting, Gauting, Not set
Franziskus-Hospital Harderberg, Georgsmarienhütte, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle-Dölau, Halle, Not set
Hämato-Onkologie Hamburg, Prof. Laack und Partner, Hamburg, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, Not set
Klinikum Nürnberg Nord, Nürnberg, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Agios Savvas Regional Cancer Hospital, Athens, Not set
Errikos Dunant Hospital Center, Athens, Not set
Sotiria Thoracic Diseases Hospital of Athens, Athens, Not set
Attikon General University Hospital, Chaidari, Not set
University General Hospital of Heraklion, Heraklion, Not set
University Hospital of Patras, Patras, Not set
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
G. Papanikolaou General Hospital, Thessaloniki, Not set
Országos Korányi Pulmonológiai Intézet, Budapest, Not set
Országos Onkológiai Intézet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Not set
Bacs-Kiskun Megyei Korhaz, Kecskemét, Not set
Hemato Oncology Clinic, Ahmedabad, Not set
KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi, Not set
SRV Hospitals, Bengaluru, Not set
All India Institute of Medical Sciences, Bhubaneswar, Not set
Ashwin Hospital, Coimbatore, Not set
Nizam's Institute of Medical Sciences, Hyderabad, Not set
Krishna Institute of Medical Sciences - Karad, Karad, Not set
Kolhapur Cancer Centre Private Limited, Kolhapur, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavata Cancer Centre, Nashik, Not set
Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry, Not set
Grant Medical Foundation - Ruby Hall Clinic, Pune, Not set
Sahyadri Super Speciality Hospital, Pune, Not set
Lifepoint Multispeciality Hospital, Pune, Not set
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Not set
Pacific Medical College & Hospital, Udaipur, Not set
Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Not set
Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam, Not set
Instituto Tumori Giovanni Paolo II, Bari, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Policlinico "G. Rodolico", Catania, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set
Istituto Oncologico Veneto IRCCS, Padova, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Istituto Nazionale Tumori Regina Elena, Rome, Not set
Ospedale di Circolo e Fondazione Macchi Varese, Varese, Not set
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
National Hospital Organization Asahikawa Medical Center, Asahikawa, Not set
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
Ibaraki Prefectural Central Hospital, Kasama, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Kobe City Medical Center General Hospital, Kobe, Not set
Japanese Foundation for Cancer Research, Koto, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Not set
Nagasaki University Hospital, Nagasaki, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
Miyagi Cancer Center, Natori, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
Kindai University Hospital- Osakasayama Campus, Osakasayama, Not set
National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Not set
Hokkaido University Hospital, Sapporo, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Ube, Not set
Tochigi Cancer Center, Utsunomiya, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Not set
Kanagawa cancer center, Yokohama, Not set
Tottori University Hospital, Yonago, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Keimyung University Dongsan Hospital, Daegu, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Health Pharma Professional Research S.A. de C.V:, Ciudad de México, Not set
CIO - Centro de Inmuno-Oncología de Occidente, Guadalajara, Not set
PanAmerican Clinical Research - Guadalajara, Guadalajara, Not set
Actualidad Basada en la Investigación del Cáncer, Guadalajara, Not set
Renati Innovation, Guadalajara, Not set
Health Pharma Querétaro, Juriquilla, Not set
Preparaciones Oncológicas S.C., León, Not set
Centro Onco-Hematológico Roma (COHR), Mexico City, Not set
Higiea Oncologia, Mexico City, Not set
Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Not set
Avix Investigación Clinica, S.C., Monterrey, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Clinica Integral Internacional de Oncología, Puebla, Not set
Oncare - Unidad Valle, San Pedro Garza García, Not set
Arké SMO S.A de C.V, Veracruz, Not set
Jeroen Bosch Hospital, Den Bosch, Not set
Medisch Spectrum Twente, Enschede, Not set
Ziekenhuis St. Jansdal, Harderwijk, Not set
Tergooiziekenhuizen, locatie Hilversum, Hilversum, Not set
Medische Centrum Leeuwarden, Leeuwarden, Not set
Leids Universitair Medisch Centrum, Leiden, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
ETZ Elisabeth, Tilburg, Not set
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Haukeland Universitetssjukehus, Bergen, Not set
Drammen Sykehus, Vestre Viken HF, Drammen, Not set
Sykehuset Innlandet HF Gjøvik, Gjøvik, Not set
Akershus Universitetssykehus, Lørenskog, Not set
Oslo universitetssykehus, Radiumhospitalet, Oslo, Not set
Stavanger Universitetssykehus, Stavanger, Not set
St. Olavs Hospital, Trondheim, Not set
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce, Not set
One Day Med, Szczecin, Not set
MICS Centrum Medyczne Torun, Torun, Not set
Centro Hospitalar E Universitário De Coimbra, Coimbra, Not set
Hospital da Luz Lisboa, Lisboa, Not set
Champalimaud Foundation, Lisbon, Not set
Hospital Pulido Valente, Lisbon, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Lotus-Med, Bucharest, Not set
SC Memorial Healthcare International SRL, Bucharest, Not set
Gral Medical Diagnostic Center, București, Not set
Institutul Oncologic, Cluj, Not set
Centrul de Oncologie "Sfântul Nectarie", Craiova, Not set
Ovidius Clinical Hospital OCH, Ovidiu, Not set
S C Oncocenter Oncologie Clinica S R L, Timișoara, Not set
Cabinet Medical Oncomed, Timișoara, Not set
CHUAC-Hospital Teresa Herrera, A Coruña, Not set
Hospital Infanta Cristina, Badajoz, Not set
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Not set
Parc de Salut Mar - Hospital del Mar, Barcelona, Not set
Hospital Universitari Dexeus, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, Not set
Hospital Jerez de la Frontera, Jerez de la Frontera, Not set
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Complejo Asistencial Universitario de León - Hospital de León, León, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitari Son Espases, Palma, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Clinico de Valencia, Valencia, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Mälarsjukhuset, Eskilstuna, Not set
Västmanlands Sjukhus Västerås, Västerås, Not set
CHUV (centre hospitalier universitaire vaudois), Lausanne, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Changhua Christian Hospital, Changhua County, Not set
Buddhist Dalin Tzu Chi General Hospital, Chiayi, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Hualien Tzu Chi Medical Center, Hualien City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Medical Center, Tainan City, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center (NTUCC), Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
National Taiwan University Hospital - Hsinchu branch, Zhu Bei City, Not set
Adana Medical Park Seyhan Hastanesi, Adana, Not set
Adana City Hospital, Adana, Not set
Ankara Etlik City Hospital, Ankara, Not set
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital, Ankara, Not set
Ankara Bilkent Şehir Hastanesi, Ankara, Not set
Akdeniz Universitesi Hastanesi, Antalya, Not set
Memorial Antalya Hospital, Antalya, Not set
Uludag Universitesi, Bursa, Not set
Dicle Üniversitesi, Diyarbakir, Not set
Bezmialem Vakf Üniversitesi, Istanbul, Not set
İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir, Not set
Kocaeli Üniversitesi, Kocaeli, Not set
Ondokuz Mayıs Universitesi, Samsun, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Cheltenham General Hospital, Cheltenham, Not set
Ninewells Hospital and Medical School, Dundee, Not set
Huddersfield Royal Infirmary, Huddersfield, Not set
St James's University Hospital, Leeds, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Mount Vernon Hospital, Northwood, Not set
Weston Park Hospital, Sheffield, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Recruiting
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Local Institution - 0347, Birmingham, Alabama +328 locations
Local Institution - 0347, Birmingham, Alabama
Local Institution - 0581, Fullerton, California
Local Institution - 0202, Long Beach, California
Local Institution - 0643, Newport Beach, California
Local Institution - 0666, Orange, California
Local Institution - 0623, Santa Barbara, California
Local Institution - 0442, Denver, Colorado
Local Institution - 0651, Gainesville, Florida
Local Institution - 0621, Palm Bay, Florida
Local Institution - 0377, Tamarac, Florida
Local Institution - 0647, Tampa, Florida
Local Institution - 0392, Fort Eisenhower, Georgia
Local Institution - 0031, Marietta, Georgia
Local Institution - 0665, Arlington Heights, Illinois
Local Institution - 0423, Munster, Indiana
Local Institution - 0366, Edgewood, Kentucky
Local Institution - 0566, Louisville, Kentucky
Local Institution - 0644, Shreveport, Louisiana
Local Institution - 0385, Columbia, Maryland
Local Institution - 0019, Boston, Massachusetts
Local Institution - 0437, Worcester, Massachusetts
Local Institution - 0618, White Plains, New York
Local Institution - 0624, Asheville, North Carolina
Local Institution - 0672, Salisbury, North Carolina
Local Institution - 0620, Columbus, Ohio
Local Institution - 0657, York, Pennsylvania
Local Institution - 0658, Greenville, South Carolina
Local Institution - 0652, Laredo, Texas
Local Institution - 0622, San Antonio, Texas
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires
Local Institution - 0584, Pilar, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0571, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Sanatorio Plaza, Rosario, Santa Fe
Local Institution - 0126, Canberra, Australian Capital Territory
Tamworth Hospital, North Tamworth, New South Wales
Orange Hospital, Orange, New South Wales
Princess Alexandra Hospital, Brisbane, Queensland
Lyell McEwin Hospital, Elizabeth Vale, South Australia
Frankston Hospital, Frankston, Victoria
Northern Hospital, Melbourne, Victoria
Latrobe Regional Health, Traralgon, Victoria
Joondalup Health Campus, Joondalup, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Medizinische Universität Wien, Wien, Not set
Local Institution - 0673, Wien, Not set
UZ Brussel, Brussels, Bruxelles-Capitale, Région De
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
Jessa Ziekenhuis, Hasselt, Limburg
AZ Maria Middelares, Gent, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0257, Salvador, Bahia
Local Institution - 0242, Vitória, Espírito Santo
Local Institution - 0244, Belo Horizonte, Minas Gerais
Local Institution - 0235, Ijui, Rio Grande Do Sul
Local Institution - 0233, Porto Alegre, Rio Grande Do Sul
Local Institution - 0238, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0243, Porto Velho, Rondonia
Local Institution - 0237, Blumenau, Santa Catarina
Local Institution - 0245, Itajaí, Santa Catarina
Local Institution - 0240, Barretos, São Paulo
Local Institution - 0254, Sao Paulo, São Paulo
Local Institution - 0241, São Carlos, São Paulo
Local Institution - 0239, São José do Rio Preto, São Paulo
Local Institution - 0236, Rio de Janeiro, Not set
Local Institution - 0258, São Paulo, Not set
Local Institution - 0629, Panagyurishte, Pazardzhik
Local Institution - 0628, Sofia, Sofia (stolitsa)
Complex Oncology Center - Ruse EOOD, Ruse, Not set
Trakia Hospital, Stara Zagora, Not set
Local Institution - 0074, Halifax, Nova Scotia
Local Institution - 0559, Montreal, Quebec
Bradfordhill, Recoleta, Región Metropolitana De Santiago
FALP, Santiago, Región Metropolitana De Santiago
The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui
Anhui Provincial Hospital, Hefei, Anhui
Beijing Cancer hospital, Beijing, Beijing
Local Institution - 0491, Beijing, Beijing
Local Institution - 0397, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Local Institution - 0362, Fuzhou Fujian, Fujian
The First Affiliated hospital of Xiamen University, Xiamen, Fujian
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Guangdong
ShenZhen People's Hospital, Shenzhen, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Nanyang City Center Hospital, Nanyang, Henan
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei
Local Institution - 0398, Changsha, Hunan
Local Institution - 0371, Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
Northern Jiangsu People's Hospital, Yangzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The First Hospital of Jilin University, Changchun, Jilin
The First Hospital of China Medical University, Shenyang, Liaoning
Shengjing Hospital of China Medical University, Shenyang, Liaoning
Local Institution - 0493, Shenyang, Liaoning
Shandong Cancer Hospital, Jinan, Shandong
LinYi Cancer Hospital, Linyi, Shandong
Local Institution - 0470, Shanghai, Shanghai
Local Institution - 0381, Shanghai, Shanghai
Shanxi Cancer Hospital, Taiyuan, Shanxi
West China Hospital, Sichuan University, Cheng Du, Sichuan
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University General Hospital, Tianjin, Tianjin
Local Institution - 0462, Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Local Institution - 0580, Medellín, Antioquia
Local Institution - 0171, Rionegro, Antioquia
Local Institution - 0191, Puerto Colombia, Atlántico
Local Institution - 0253, Valledupar, Cesar
Local Institution - 0167, Montería, COR
Local Institution - 0671, Bogota, Cundinamarca
Local Institution - 0189, Bogotá, Distrito Capital De Bogotá
Local Institution - 0170, Floridablanca, Santander
Local Institution - 0173, Cali, Valle Del Cauca
Local Institution - 0619, Dubrovnik, Dubrovačko-neretvanska Županija
Local Institution - 0664, Rijeka, Primorsko-goranska Županija
Local Institution - 0639, Split, Splitsko-dalmatinska Županija
Local Institution - 0567, Osijek, Not set
Local Institution - 0585, Zagreb, Not set
Local Institution - 0159, Mulhouse, Alsace
Centre François Baclesse, Caen, Calvados
Centre Georges François Leclerc, Dijon, Côte-d'Or
CHRU de Brest, Brest, Finistère
Institut Régional du Cancer Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
Local Institution - 0560, Angers, Maine-et-Loire
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Meurthe-et-Moselle
Local Institution - 0636, Marseille, Provence-Alpes-Côte-d'Azur
CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme
Gustave Roussy, Villejuif, Val-de-Marne
Hôpital Ambroise Paré, Boulogne-Billancourt, Not set
Chu Gabriel Montpied, Clermont-Ferrand, Not set
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Local Institution - 0133, Paris, Not set
Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Not set
Klinikum Esslingen, Esslingen, Baden-Württemberg
Local Institution - 0670, Ulm, Baden-Württemberg
Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bayern
Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen
Local Institution - 0535, Gießen, Hessen
Praxis Onkologie am Raschplatz, Hannover, Niedersachsen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Evangelisches Krankenhaus Herne - Eickel, Herne, Nordrhein-Westfalen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Local Institution - 0522, Halle, Sachsen-Anhalt
Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein
Local Institution - 0524, Gera, Thüringen
Universitätsklinikum Jena, Jena, Thüringen
Vivantes Klinikum Neukölln, Berlin, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Local Institution - 0675, Halle, Not set
Local Institution - 0528, Hemer, Not set
Local Institution - 0517, Stuttgart, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
University General Hospital of Larissa, Larissa, Thessalía
Queen Mary Hospital, Hksar, Not set
Queen Mary Hospital, Hksar, Not set
Local Institution - 0144, Gyöngyös, Heves
Local Institution - 0157, Tatabánya, Komárom-Esztergom
Local Institution - 0593, Kaposvár, Somogy
Local Institution - 0143, Farkasgyepu, Veszprém
Local Institution - 0151, Budapest, Not set
Local Institution - 0140, Budapest, Not set
Petz Aladar Egyetemi Oktato Korhaz, Győr, Not set
Local Institution - 0222, Visakhapatnam, Andhra Pradesh
Local Institution - 0312, New Delhi, Delhi
Local Institution - 0511, New Delhi, Delhi
Local Institution - 0135, New Delhi, Delhi
Local Institution - 0136, Ahmedabad, Gujarat
Local Institution - 0230, Ahmedabad, Gujarat
Local Institution - 0155, Thiruvananthapuram, Kerala
Local Institution - 0154, Mumbai, Maharashtra
Local Institution - 0226, Bhubaneswar, Odisha
Local Institution - 0224, Madurai, Tamil Nadu
Local Institution - 0663, Hyderabad, Telangana
Local Institution - 0153, Varanasi, Uttar Pradesh
Local Institution - 0161, Howrah, West Bengal
Local Institution - 0221, Kolkata, West Bengal
Local Institution - 0661, Hyderabad, Not set
Local Institution - 0102, Cork, Not set
Mater Private Hospital - Dublin, Dublin, Not set
St. James's Hospital, Dublin, Not set
Local Institution - 0100, Dublin, Not set
Beaumont Hospital, Dublin, Dublin, Not set
Rabin Medical Center, Petah Tikva, HaMerkaz
Sheba Medical Center, Ramat Gan, HaMerkaz
Yitzhak Shamir Medical Center, Zerifin, HaMerkaz
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0613, Haifa, Ḥeifā
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna
A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli
Local Institution - 0070, Orbassano, Piemonte
Local Institution - 0071, Bari, Puglia
Local Institution - 0068, Rome, Roma
Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana
Ospedale San Martino, Genova, Not set
Local Institution - 0073, Padova, Not set
Local Institution - 0156, Parma, Not set
Local Institution - 0543, Pavia, Not set
Local Institution - 0556, Varese, Not set
Local Institution - 0607, Nagoya, Aichi
Local Institution - 0305, Nagoya, Aichi
Local Institution - 0298, Sapporo, Hokkaido
Local Institution - 0304, Kanazawa, Ishikawa
Local Institution - 0302, Sagamihara, Kanagawa
Local Institution - 0369, Yokohama, Kanagawa
Local Institution - 0301, Sendai, Miyagi
Local Institution - 0306, Kashihara, Nara
Local Institution - 0368, Kurashiki, Okayama
Local Institution - 0642, Hirakata, Osaka
Local Institution - 0303, Hidaka, Saitama
Local Institution - 0300, Ina-machi, Saitama
Local Institution - 0606, Hamamatsu, Shizuoka
Local Institution - 0299, Shimotsuga, Tochigi
Local Institution - 0674, Bunkyo ku, Tokyo
Local Institution - 0343, Toyoma, Toyama
Local Institution - 0542, Iwakuni, Yamaguchi
Local Institution - 0307, Akashi, Not set
Local Institution - 0346, Aomori, Not set
Local Institution - 0310, Fukuoka, Not set
Local Institution - 0367, Fukushima, Not set
Local Institution - 0308, Kumamoto, Not set
Local Institution - 0297, Osaka, Not set
Local Institution - 0309, Osaka, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon]
Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0583, Saltillo, Coahuila
Local Institution - 0176, Mexico City, DIF
Local Institution - 0579, Pachuca, Hidalgo
Local Institution - 0178, Guadalajara, Jalisco
Local Institution - 0591, Monterrey, Nuevo León
Local Institution - 0175, Chihuahua, Not set
Local Institution - 0181, Puebla, Not set
Local Institution - 0638, Puebla, Not set
Local Institution - 0180, Veracruz, Not set
Local Institution - 0615, Maastricht, Limburg
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, Noord-Holland
Local Institution - 0205, Wrocław, Dolnośląskie
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lubelskie
Szpital Specjalistyczny im. Henryka Klimontowicza, Gorlice, Małopolskie
Pratia MCM Krakow, Kraków, Małopolskie
Med-Polonia Sp. z o. o., Poznan, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Local Institution - 0078, Katowice, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Not set
Local Institution - 0509, Lisbon, Lisboa
Instituto Portugês de Oncologia de Coimbra Francisco Gentil, Coimbra, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
Cardiomed SRL Cluj-Napoca, Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Ovidius Clinical Hospital OCH, Ovidiu, Constanța
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Spitalul Municipal Schuller Ploiești, Ploiești, Prahova
Cabinet Medical Oncomed, Timișoara, Timiș
Institutul Oncologic Cluj, Cluj, Not set
Institutul Oncologic Cluj, Cluj, Not set
Affidea Constanța, Constanța, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0614, Jeddah, Makkah Al Mukarramah
Local Institution - 0602, Riyadh, Not set
Local Institution - 0562, Riyadh, Not set
Local Institution - 0499, A Coruña, A Coruña [La Coruña]
Local Institution - 0506, Santiago de Compostela, A Coruña [La Coruña]
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]
Local Institution - 0497, Hospitalet, Barcelona [Barcelona]
Local Institution - 0505, Barcelona, Catalunya [Cataluña]
Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares]
Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Local Institution - 0669, Pontevedra, Pontevedra [Pontevedra]
Hospital Arnau de Vilanova, Valencia, València
Hospital Clinico San Carlos, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Local Institution - 0495, València, Not set
Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Tainan
Tri-Service General Hospital, Taipei City, Taipei
Taipei Medical University Shuang Ho Hospital, New Taipei, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Local Institution - 0565, Muang, Khon Kaen
Local Institution - 0563, Bangkok, Krung Thep Maha Nakhon
Local Institution - 0564, Hatyai, Songkhla
Local Institution - 0548, Stanbul, İstanbul
Local Institution - 0199, Izmir, Karsiyaka, İzmir
Local Institution - 0197, Adana, Not set
Local Institution - 0201, Ankara, Not set
Local Institution - 0194, Ankara, Not set
Local Institution - 0198, Ankara, Not set
Local Institution - 0550, Istanbul, Not set
Local Institution - 0549, Istanbul, Not set
Local Institution - 0200, Izmir, Not set
University College London Hospital, London, London, City Of
Guy's & St Thomas' NHS Foundation Trust, London, London, City Of
Heartlands Hospital, Birmingham, Not set
Local Institution - 0545, Guildford, Not set
The Royal Surrey County Hospital, Guildford, Not set
Local Institution - 0093, Manchester, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
Recruiting
The purpose of this study is to compare pembrolizumab (MK-3475) in combination with sacituzumab govitecan with pembrolizumab alone with respect to progression-free survival (PFS) and overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review (BICR) among adults with metastatic non-small cell lung cancer (NSCLC) with programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%).
The purpose of this study is to compare pembrolizumab (MK-3475) in combination with sacituzumab govitecan with pembrolizumab alone with respect to progression-free survival (PFS) and overall survival (OS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review (BICR) among adults with metastatic non-small cell lung cancer (NSCLC) with programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Infirmary Cancer Care ( Site 0418), Mobile, Alabama +177 locations
Infirmary Cancer Care ( Site 0418), Mobile, Alabama
Clermont Oncology Center ( Site 0421), Clermont, Florida
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0417), Miami, Florida
Mid Florida Hematology and Oncology Center ( Site 0416), Orange City, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0407), Marietta, Georgia
Our Lady of the Lake RMC ( Site 0424), Baton Rouge, Louisiana
Henry Ford Hospital ( Site 0412), Detroit, Michigan
Profound Research LLC ( Site 0440), Farmington Hills, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0425), Minneapolis, Minnesota
Basil Clinical ( Site 0441), Inwood, New York
White Plains Hospital-Center for Cancer Care ( Site 0403), White Plains, New York
Kaiser Permanente Northwest-Central Interstate--Oncology ( Site 0408), Portland, Oregon
Oregon Health & Science University ( Site 0427), Portland, Oregon
Houston Methodist Hospital ( Site 0419), Houston, Texas
Central Texas Veterans health care ( Site 0414), Temple, Texas
Orange Hospital-Clinical Trials Unit ( Site 0600), Orange, New South Wales
Cancer Research SA-St Andrews Hospital ( Site 0603), Adelaide, South Australia
Frankston Hospital-Oncology and Haematology ( Site 0601), Frankston, Victoria
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0320), Fortaleza, Ceara
Hospital Tacchini ( Site 0322), Bento Goncalves, Rio Grande Do Sul
Hospital da Cidade de Passo Fundo ( Site 0321), Passo Fundo, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0317), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0318), Barretos, Sao Paulo
A. C. Camargo Cancer Center ( Site 0324), Sao Paulo, Not set
BC Cancer Abbotsford-Medical Oncology ( Site 0433), Abbotsford, British Columbia
Southlake Regional Health Centre-Oncology Clinical Trials ( Site 0435), Newmarket, Ontario
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0430), Greenfield Park, Quebec
St. Marys Hospital Center-Oncology ( Site 0434), Montreal, Quebec
Centre integre universitaire de sante et de services sociaux-oncology ( Site 0431), Trois-Rivières, Quebec
Oncovida ( Site 0334), Santiago., Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 0332), Santiago, Region M. De Santiago
Second Affiliated hospital of Anhui Medical University ( Site 0126), Hefei, Anhui
Anhui Provincial Hospital ( Site 0136), Hefei, Anhui
Beijing Cancer hospital ( Site 0104), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 0106), Beijing, Beijing
Beijing Chest Hospital,Capital Medical University ( Site 0105), Beijing, Beijing
Chongqing University Cancer Hospital-Medical Oncology ( Site 0130), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 0131), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 0132), Xiamen, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 0125), Guangzhou, Guangdong
Affiliated Cancer Hospital of Guangxi Medical University ( Site 0113), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 0119), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 0127), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 0116), Wuhan, Hubei
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0115), Wuhan, Hubei
Hubei Cancer Hospital ( Site 0107), Wuhan, Hubei
Xiangya Hospital Central South University ( Site 0124), Changsha, Hunan
The Second Xiangya Hospital of Central South University ( Site 0135), Changsha, Hunan
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0112), Nanjing, Jiangsu
Nantong Tumor Hospital-Medical Oncology ( Site 0122), Nantong, Jiangsu
The First Affliated Hospital of Suzhou University ( Site 0114), Suzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 0134), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 0117), Changchun, Jilin
Jilin Province Tumor Hospital-clinical research ( Site 0118), Changchun, Jilin
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0133), Xi'an, Shaanxi
Jinan Central Hospital-oncology department ( Site 0121), Jinan, Shandong
LinYi Cancer Hospital ( Site 0120), Linyi, Shandong
Shanghai Chest Hospital ( Site 0101), Shanghai, Shanghai
Fudan University Shanghai Cancer Center-Oncology ( Site 0102), Shanghai, Shanghai
Huashan Hospital, Fudan University ( Site 0103), Shanghai, Shanghai
West China Hospital of Sichuan University ( Site 0129), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 0128), Chengdu, Sichuan
The First Affiliated Hospital, Zhejiang University ( Site 0109), Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0110), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital-Medical Oncology ( Site 0111), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 0108), Hangzhou, Zhejiang
North Estonia Medical Centre Foundation-Chemotherapy ( Site 0621), Tallinn, Harjumaa
Tartu University Hospital-Radiotherapy and oncology ( Site 0620), Tartu, Tartumaa
Universitätsmedizin Mannheim ( Site 0654), Mannheim, Baden-Wurttemberg
Klinikum Kempten ( Site 0655), Kempten, Bayern
Klinikum Würzburg Mitte ( Site 0651), Wuerzburg, Bayern
Katholisches Klinikum Koblenz ( Site 0650), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 0657), Halle, Sachsen-Anhalt
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 0656), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 0653), Berlin, Not set
Errikos Dunant Hospital Center-Fourth Department of Oncology and Clinical Trials Unit ( Site 0141), Athens, Attiki
Sotiria Thoracic Diseases Hospital of Athens-3rd Dept of Internal Medicine, Oncology Unit ( Site 0140), Athens, Attiki
European Interbalkan Medical Center-Oncology Department ( Site 0142), Thessaloniki, Not set
Shaare Zedek Medical Center-Oncology ( Site 0176), Jerusalem, Not set
Meir Medical Center-oncology ( Site 0171), KfarSaba, Not set
Rabin Medical Center-Oncology ( Site 0174), Petah Tikva, Not set
Sourasky Medical Center-Oncology ( Site 0175), Tel Aviv, Not set
Yitzhak Shamir Medical Center. ( Site 0179), Zerifin, Not set
Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 0677), Roma, Lazio
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 0674), Bergamo, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0673), Milan, Lombardia
Azienda Ospedaliera Dei Colli-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 0671), Naples, Napoli
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 0675), Firenze, Toscana
Casa di Cura Dott. Pederzoli-LUNG-UNIT TORACIC ( Site 0670), Peschiera del Garda, Verona
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 0676), Parma, Not set
Aichi Cancer Center ( Site 0018), Nagoya, Aichi
National Hospital Organization Shikoku Cancer Center ( Site 0008), Matsuyama, Ehime
Kurume University Hospital ( Site 0014), Kurume, Fukuoka
Takarazuka City Hospital ( Site 0015), Takarazuka, Hyogo
Kanazawa University Hospital ( Site 0019), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0016), Yokohama, Kanagawa
Miyagi Cancer Center ( Site 0001), Natori, Miyagi
Sendai Kousei Hospital ( Site 0012), Sendai, Miyagi
Niigata Cancer Center Hospital ( Site 0017), Niigata-shi, Niigata
Kurashiki Central Hospital ( Site 0011), Kurashiki, Okayama
Kansai Medical University Hospital ( Site 0005), Hirakata, Osaka
Kindai University Hospital ( Site 0013), Sayama, Osaka
Saitama Prefectural Cancer Center ( Site 0002), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 0004), Nagaizumi-cho,Sunto-gun, Shizuoka
Tokyo Metropolitan Komagome Hospital ( Site 0020), Bunkyo ku, Tokyo
National Hospital Organization Kyushu Medical Center ( Site 0009), Fukuoka, Not set
Kyushu University Hospital ( Site 0010), Fukuoka, Not set
Okayama University Hospital ( Site 0007), Okayama, Not set
Nippon Medical School Hospital ( Site 0003), Tokyo, Not set
Wakayama Medical University Hospital ( Site 0006), Wakayama, Not set
Chonnam National University Hwasun Hospital-Pulmonology ( Site 0061), Hwasun, Jeonranamdo
Pusan National University Yangsan Hospital ( Site 0060), Pusan, Kyongsangnam-do
Chungnam national university hospital-Department of Internal Medicine ( Site 0063), Daejeon, Taejon-Kwangyokshi
Asan Medical Center ( Site 0064), Seoul, Not set
Korea University Guro Hospital-Internal Medicine ( Site 0062), Seoul, Not set
Daugavpils Regional Hospital-Oncology Department ( Site 0194), Daugavpils, Daugavpils Novads
Liepjas reionl slimnca ( Site 0191), Liepaja, Not set
Pauls Stradins Clinical Univeristy Hospital-Chemotherapy department ( Site 0192), Riga, Not set
RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 0193), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 0692), Kaunas, Kauno Apskritis
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 0691), Vilnius, Vilniaus Miestas
Hospital Raja Perempuan Zainab II-Medical Department ( Site 0035), Kota Bharu, Kelantan
Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 0034), George Town, Pulau Pinang
Beacon Hospital Sdn Bhd ( Site 0033), Petaling Jaya, Selangor
COI Tijuana - Centro Oncológico Internacional ( Site 0350), Tijuana, Baja California
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0352), Monterrey, Nuevo Leon
Medical Care and Research SA de CV ( Site 0353), Merida, Yucatan
Centro de Investigacion Medica Aguascalientes ( Site 0340), Aguascalientes, Not set
Oaxaca Site Management Organization ( Site 0346), Oaxaca, Not set
Centro de Investigacion Clinica de Oaxaca ( Site 0351), Oaxaca, Not set
Clinica Vallesur - AUNA ( Site 0360), Arequipa, Ariqipa
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 0362), Concepcion, Junin
Centro de investigacion Clínica Trujillo ( Site 0358), Trujillo, La Libertad
Detecta Clínica ( Site 0364), Surquillo, Lima
Clínica Internacional - Sede San Borja ( Site 0356), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0365), Lima, Not set
Hospital Cayetano Heredia ( Site 0361), Lima, Not set
Metro Davao Medical and Research Center ( Site 0047), Davao City, Davao Del Sur
ST. LUKE'S MEDICAL CENTER ( Site 0046), Quezon City, National Capital Region
Cebu Doctors University Hospital ( Site 0045), Cebu, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 0208), Bydgoszcz, Kujawsko-pomorskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0201), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0200), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0203), Przemysl, Podkarpackie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 0202), Prabuty, Pomorskie
Szpital Rejonowy im. dr. J. Rostka w Raciborzu ( Site 0207), Racibórz, Slaskie
Med-Polonia Sp. z o. o. ( Site 0204), Poznan, Wielkopolskie
Gral Medical SRL-Medical Oncology ( Site 0220), București, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 0217), Cluj-Napoca, Cluj
Amethyst Radiotherapy Center-Oncologie Medicala ( Site 0216), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 0215), Craiova, Dolj
Cabinet Medical Oncomed ( Site 0219), Timisoara, Timis
Institutul Oncologic-Oncologie Medicala ( Site 0218), Cluj, Not set
Chung Shan Medical University Hospital ( Site 0078), Taichung City, Taichung
National Taiwan University Cancer Center (NTUCC) ( Site 0079), Taipei City, Taipei
E-Da hospital ( Site 0075), Kaohsiung, Not set
China Medical University Hospital-Internal Medicine ( Site 0083), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 0076), Tainan, Not set
National Taiwan University Hospital-Internal Medicine ( Site 0080), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch ( Site 0082), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 0092), Muang, Chiang Mai
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0097), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital ( Site 0090), Bangkok, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 0098), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 0091), HatYai, Songkhla
Sunpasitthiprasong Hospital ( Site 0093), Ubon Ratchathani, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 0265), Ankara, Not set
Liv Hospital Ankara-Oncology ( Site 0274), Ankara, Not set
Ankara City Hospital-Medical Oncology ( Site 0268), Ankara, Not set
Trakya University-Medical Oncology ( Site 0270), Edirne, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0267), Istanbul, Not set
VM Medical Park Pendik Hospital ( Site 0271), Istanbul, Not set
I.E.U. Medical Point Hastanesi-Oncology ( Site 0266), Izmir, Not set
Mersin Sehir Eğitim ve Araştırma Hastanesi ( Site 0275), Mersin, Not set
Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 0300), Leicester, Leicestershire
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 0302), London, London, City Of
University College London Hospital ( Site 0305), London, London, City Of
The Clatterbridge Cancer Centre ( Site 0303), Wirral, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of repotrectinib and crizotinib in participants with locally advanced or metastatic TKI-naïve ROS1-positive non-small cell lung cancer (NSCLC).
The purpose of this study is to evaluate the efficacy and safety of repotrectinib and crizotinib in participants with locally advanced or metastatic TKI-naïve ROS1-positive non-small cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Local Institution - 0136, Augusta, Georgia +143 locations
Local Institution - 0136, Augusta, Georgia
Local Institution - 0221, Des Moines, Iowa
Massachusetts General Hospital, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Local Institution - 0217, Brooklyn, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York
Laura and Isaac Perlmutter Cancer Center, New York, New York
Local Institution - 0127, Syracuse, New York
Local Institution - 0214, Tacoma, Washington
Local Institution - 0061, Milwaukee, Wisconsin
Local Institution - 0092, Ciudad autónoma de Buenos Aires, Buenos Aires
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0091, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0106, Buenos Aires, Not set
Local Institution - 0207, Buenos Aires, Not set
Instituto Oncológico de Córdoba, Córdoba, Not set
Local Institution - 0041, Wien, Not set
Local Institution - 0073, Belo Horizonte, Minas Gerais
Local Institution - 0033, Porto Alegre, Rio Grande Do Sul
Local Institution - 0034, Porto Alegre, Rio Grande Do Sul
Local Institution - 0029, Barretos, São Paulo
Local Institution - 0209, Sao Paulo, São Paulo
Local Institution - 0147, Sao Paulo, São Paulo
Local Institution - 0037, São José do Rio Preto, São Paulo
Local Institution - 0098, Rio de Janeiro, Not set
Local Institution - 0108, Rio de Janeiro, Not set
Local Institution - 0032, São Paulo, Not set
Local Institution - 0114, São Paulo, Not set
Local Institution - 0002, Toronto, Ontario
Local Institution - 0123, Trois-Rivières, Quebec
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Oncocentro Apys, Viña del Mar, Valparaíso
Local Institution - 0168, Beijing, Beijing
Local Institution - 0185, Chongqing, Chongqing
Local Institution - 0192, Fuzhou, Fujian
Local Institution - 0169, Xiamen, Fujian
Local Institution - 0180, Guangzhou, Guangdong
Local Institution - 0194, Nanning, Guangxi
Local Institution - 0171, Harbin, Heilongjiang
Local Institution - 0166, Zhengzhou, Henan
Local Institution - 0181, Wuhan Shi, Hubei
Local Institution - 0203, Wuhan, Hubei
Local Institution - 0184, Changsha, Hunan
Local Institution - 0165, Changsha, Hunan
Local Institution - 0193, Nanjing, Jiangsu
Local Institution - 0202, Nanchang, Jiangxi
Local Institution - 0178, Changchun, Jilin
Local Institution - 0183, Xi'an, Shaanxi
Local Institution - 0186, Jinan, Shandong
Local Institution - 0205, Linyi, Shandong
Local Institution - 0164, Shanghai, Shanghai
Local Institution - 0179, Shanghai, Shanghai
Local Institution - 0170, Chengdu, Sichuan
Local Institution - 0177, Chengdu, Sichuan
Local Institution - 0204, Kunming, Yunnan
Local Institution - 0206, Hangzhou, Zhejiang
Local Institution - 0175, Hangzhou, Zhejiang
Nouvel Hôpital Civil (NHC), Strasbourg, Alsace
CHU Bordeaux Haut-Leveque, Pessac, Aquitaine
Centre Georges François Leclerc, Dijon, Côte-d'Or
CHU Charles Nicolle, Rouen, Haute-Normandie
Chu Grenoble Alpes, La Tronche, Isère
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Loire-Atlantique
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set
Klinikum Esslingen, Esslingen, Baden-Württemberg
Klinikum Würzburg Mitte, Wuerzburg, Bayern
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Evangelische Lungenklinik Berlin, Berlin, Not set
Local Institution - 0035, Dresden, Not set
Asklepios Klinik Gauting GmbH, Gauting, Not set
Lungenfachklinik Immenhausen, Immenhausen, Not set
Universitaetsklinikum Koeln, Köln, Not set
Marienhaus Klinikum Mainz, Mainz, Not set
University Hospital of Patras, Patras, Achaḯa
Local Institution - 0153, Athens, Attikí
Local Institution - 0155, Chaidari, Attikí
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía
Országos Korányi Pulmonológiai Intézet, Budapest, Not set
All India Institute of Medical Sciences, New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Hemato Oncology Clinic, Ahmedabad, Gujarat
HCG Aastha Cancer Centre, Ahmedabad, Gujarat
Local Institution - 0117, Gurgaon, Haryana
Artemis hospital, Gurugram, Haryana
Manipal Hospitals, Bengaluru, Karnataka
Local Institution - 0219, Thiruvananthapuram, Kerala
Local Institution - 0065, Mumbai, Maharashtra
Local Institution - 0048, Mumbai, Maharashtra
Grant Medical Foundation - Ruby Hall Clinic, Pune, Maharashtra
Sahyadri Super Speciality Hospital, Pune, Maharashtra
Local Institution - 0220, Hyderabad, Telangana
Cro-Irccs, Aviano, Friuli-Venezia Giulia
Local Institution - 0152, Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori, Monza, Lombardia
A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli
Local Institution - 0148, Rome, Roma
Nagoya University Hospital, Nagoya, Aichi
National Cancer Center Hospital East, Kashiwa, Chiba
Local Institution - 0174, Matsuyama-shi, Ehime
Hokkaido University Hospital, Sapporo, Hokkaido
Kanagawa cancer center, Yokohama, Kanagawa
Sendai Kosei Hospital, Sendai, Miyagi
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo
Tottori University Hospital, Yonago, Tottori
Local Institution - 0195, Fukuoka, Not set
Osaka City General Hospital, Osaka, Not set
Osaka International Cancer Institute, Osaka, Not set
Tokyo Metropolitan Police Hospital, Tokyo, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0223, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0237, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0222, Lembah Pantai, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0226, Lembah Pantai, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0224, Putrajaya, Wilayah Persekutuan Kuala Lumpur
Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland
Local Institution - 0215, Groningen, Not set
Local Institution - 0187, Lublin, Lubelskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie, Olsztyn, Warmińsko-mazurskie
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Institutul Oncologic Cluj, Cluj, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
CHUAC-Hospital Teresa Herrera, A Coruña, A Coruña [La Coruña]
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Universitari i Politecnic La Fe, València, Not set
Kantonspital Baden, Baden, Aargau
Ankara Bilkent Şehir Hastanesi, Yenimahalle, Ankara
Adana Medical Park Seyhan Hastanesi, Adana, Not set
Sbü Gülhane Eğitim Ve Araştirma Hastanesi, Ankara, Not set
Medipol Mega Universite Hastanesi, Istanbul, Not set
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Istanbul, Not set
VM Medical Park Pendik Hospital, Istanbul, Not set
Sakarya Training and Research Hospital, Sakarya, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer
Recruiting
The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.
The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Hackensack University Medical Center, Hackensack, New Jersey +12 locations
Hackensack University Medical Center, Hackensack, New Jersey
Roswell Park Comprehensive Cancer Center, Buffalo, New York
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York, New York
Thomas Jefferson University, Philadelphia, Pennsylvania
Next Virginia, Fairfax, Virginia
Charite Research Organisation GmbH, Berlin, Not set
Universitaetsklinikum Giessen und Marburg GmbH, Giessen, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Hosp. Univ. Quiron Dexeus, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. I Politecni La Fe, Valencia, Not set
Conditions: Carcinoma, Non-small-Cell Lung
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Recruiting
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
* Are confirmed to have NSCLC (Stage 3 or 4).
* Have PD-L1 levels in more than 50% of the cancer cells.
All participants in... Read More
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
* Are confirmed to have NSCLC (Stage 3 or 4).
* Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Cancer Centers of Colorado St. Mary's Regional Hospital, Grand Junction, Colorado +61 locations
Cancer Centers of Colorado St. Mary's Regional Hospital, Grand Junction, Colorado
Intermountain Health St. Mary's Regional Hospital, Grand Junction, Colorado
Intermountain Health, Grand Junction, Colorado
Mid Florida Hematology and Oncology Center, Orange City, Florida
BRCR Global, Plantation, Florida
Hope and Healing Cancer Services, Hinsdale, Illinois
Hope and Healing Cancer Services, New Lenox, Illinois
Jackson Oncology Associates, PLLC, Jackson, Mississippi
Jackson Oncology Associates, PLLC, Jackson, Mississippi
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont, Fremont, Nebraska
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island, Grand Island, Nebraska
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional, Grand Island, Nebraska
Cancer Partners of Nebraska - April Sampson Cancer Center, Lincoln, Nebraska
Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist, Omaha, Nebraska
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan, Omaha, Nebraska
Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha, Nebraska
Hematology Oncology Associates of Rockland, Nyack, New York
Renovatio Clinical - El Paso, El Paso, Texas
Renovatio Clinical, The Woodlands, Texas
Woodlands Radiology, The Woodlands, Texas
AZ Sint-Maarten, Mechelen, Antwerpen
UZ Brussel, Brussels, Bruxelles-capitale, Région DE
Algemeen Ziekenhuis klina, Brasschaat, Not set
Complex Oncology Center - Burgas, Burgas, Not set
MHAT for Women's Health Nadezhda, Sofia, Not set
Fakultni Thomayerova nemocnice, Praha, Praha 4
Centre Hospitalier de Cholet, Cholet, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Institut Curie, Paris, Not set
Klinikum Esslingen, Esslingen, Baden-württemberg
Rabin Medical Center, Petah Tikva, Hamerkaz
Shaare Zedek Medical Center, Jerusalem, Yerushalayim
Azienda Ospedaliera San Giuseppe Moscati, Avellino, Not set
Gunma Prefectural Cancer Center, Otashi, Gunma
National Hospital Organization Asahikawa Medical Center, Asahikawa, Hokkaido
Kobe City Medical Center General Hospital, Kobe, Hyogo
Kanagawa cancer center, Yokohama, Kanagawa
Mie Chuo Medical Center, Tsu, MIE
Sendai Kousei Hospital, Sendai, Miyagi
NHO Kinki Chuo Chest Medical Center, Sakai, Osaka
The University of Osaka Hospital, Suita, Osaka
Nippon Medical School Hospital, Bunkyo-ku, Tokyo
National Cancer Center Hospital, Chuo-ku, Tokyo
The Cancer Institute Hospital of JFCR, Koto, Tokyo
National Hospital Organization Tokyo Medical Center, Meguro-Ku, Tokyo
Yamagata University Hospital, Yamagata-Shi, Yamagata
National Hospital Organization Kyushu Medical Center, Fukuoka, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
National Hospital Organization Kyoto Medical Center, Kyoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka International Cancer Institute, Osaka, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Kyǒnggi-do
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [seoul]
Kyungpook National University Chilgok Hospital, Deagu, Taegu-kwangyǒkshi
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Instytut Genetyki i Immunologii GENIM, Lublin, Lubelskie
Instytut MSF Sp zoo, Lodz, Łódzkie
Hospital General Universitario de Elche, Elche, Alicante
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [barcelona]
Hospital Jerez de la Frontera, Jerez de la Frontera, Cádiz
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad DE
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Conditions: Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
Recruiting
The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose.
This study is seeking participants who have solid tumors (a mass of abnormal cells that forms a lump or growth in the body) that:
* are advanced (cancer that doesn't disappear or stay away with treatment) and
* have a KRAS gene mutation (a change in the DNA of the KRAS gene that can cause cells to gro... Read More
The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose.
This study is seeking participants who have solid tumors (a mass of abnormal cells that forms a lump or growth in the body) that:
* are advanced (cancer that doesn't disappear or stay away with treatment) and
* have a KRAS gene mutation (a change in the DNA of the KRAS gene that can cause cells to grow in very high numbers).
This includes (but limited to) the following cancer types:
Non-Small Cell Lung Cancer (NSCLC): It's a type of lung cancer where the cells grow slowly but often spread to other parts of the body.
Colorectal Cancer (CRC): This is a disease where cells in the colon (a part of large intestine) or rectum grow out of control.
Pancreatic ductal adenocarcinoma (PDAC): This is a cancer that starts in the ducts of the pancreas but can spread quickly to other parts of the body. Pancreas is a long, flat gland that lies in the abdomen behind the stomach. Pancreas creates enzymes that help with digestion. It also makes hormones that can help control your blood sugar levels.
All participants in this study will take the study medication (PF-07934040) as pill by mouth twice a day repeating for 21-day or 28-day cycles.
Depending on which part of the study participants are enrolled into they will receive the study medication (PF-07934040 alone or in combination with other anti-cancer medications). These anti-cancer medications will be given in the study clinic by intravenous (IV) that is directly injected into the veins at various times (depending on the treatment) during the 21-day or 28-day cycle.
Participants can continue to take the study medication (PF-07934040) and the combination anti-cancer therapy until their cancer is no longer responding.
The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and effective.
Participants will be involved in this study for up to 4 years. During this time, they will come into the clinic between 1 to 4 times in each 21-day or 28-day cycle. After they have stopped taking the study medication (at about at 2 years) they will be followed for another two years to see how they are doing. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Highlands Oncology Group, PA, Fayetteville, Arkansas +24 locations
Highlands Oncology Group, PA, Fayetteville, Arkansas
Highlands Oncology Group, PA, Rogers, Arkansas
Highlands Oncology Group, Springdale, Arkansas
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California
City of Hope Investigational Drug Service (IDS), Duarte, California
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora, Colorado
University of Colorado Hospital - Anschutz Outpatient Pavilion, Aurora, Colorado
University of Colorado Hospital- Anschutz Cancer Pavilion (ACP), Aurora, Colorado
University of Colorado Hospital, Aurora, Colorado
START Midwest, Grand Rapids, Michigan
Siteman Cancer Center - West County, Creve Coeur, Missouri
Siteman Cancer Center - North County, Florissant, Missouri
Siteman Cancer Center, Saint Louis, Missouri
Barnes-Jewish Hospital, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center - South County, Saint Louis, Missouri
Siteman Cancer Center - St Peters, Saint Peters, Missouri
Duke University Medical Center, lnvestigational Chemotherapy Service, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
West Chester Hospital, West Chester, Ohio
Rhode Island Hospital, Providence, Rhode Island
Miriam Hospital, Providence, Rhode Island
University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS
Recruiting
The purpose of the study is to assess the efficacy of durvalumab plus tremelimumab in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy in metastatic NSCLC patients with non-squamous histology who have mutations and/or co-mutations in STK11, KEAP1, or KRAS.
The purpose of the study is to assess the efficacy of durvalumab plus tremelimumab in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy in metastatic NSCLC patients with non-squamous histology who have mutations and/or co-mutations in STK11, KEAP1, or KRAS. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/14/2025
Locations: Research Site, Birmingham, Alabama +104 locations
Research Site, Birmingham, Alabama
Research Site, Anchorage, Alaska
Research Site, Chandler, Arizona
Research Site, Tucson, Arizona
Research Site, Irvine, California
Research Site, La Jolla, California
Research Site, Loma Linda, California
Research Site, Los Alamitos, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Redding, California
Research Site, Santa Monica, California
Research Site, Denver, Colorado
Research Site, Wheat Ridge, Colorado
Research Site, Washington, District of Columbia
Research Site, Washington, District of Columbia
Research Site, Fort Lauderdale, Florida
Research Site, Jupiter, Florida
Research Site, Ocala, Florida
Research Site, Orlando, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tampa, Florida
Research Site, Tampa, Florida
Research Site, Albany, Georgia
Research Site, Atlanta, Georgia
Research Site, Atlanta, Georgia
Research Site, Atlanta, Georgia
Research Site, Atlanta, Georgia
Research Site, Columbus, Georgia
Research Site, Honolulu, Hawaii
Research Site, Carterville, Illinois
Research Site, Chicago, Illinois
Research Site, Chicago, Illinois
Research Site, Maywood, Illinois
Research Site, Urbana, Illinois
Research Site, Dyer, Indiana
Research Site, Evansville, Indiana
Research Site, Westwood, Kansas
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Bethesda, Maryland
Research Site, Jamaica Plain, Massachusetts
Research Site, Worcester, Massachusetts
Research Site, Detroit, Michigan
Research Site, Farmington Hills, Michigan
Research Site, Lansing, Michigan
Research Site, Traverse City, Michigan
Research Site, Saint Paul, Minnesota
Research Site, Kansas City, Missouri
Research Site, Kansas City, Missouri
Research Site, Saint Louis, Missouri
Research Site, Saint Louis, Missouri
Research Site, Billings, Montana
Research Site, Grand Island, Nebraska
Research Site, Lincoln, Nebraska
Research Site, Albany, New York
Research Site, Bronx, New York
Research Site, Bronx, New York
Research Site, Clifton Park, New York
Research Site, East Syracuse, New York
Research Site, Mineola, New York
Research Site, New Hyde Park, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, Northport, New York
Research Site, Shirley, New York
Research Site, Stony Brook, New York
Research Site, Syracuse, New York
Research Site, Westbury, New York
Research Site, Bismarck, North Dakota
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Dayton, Ohio
Research Site, Maumee, Ohio
Research Site, Perrysburg, Ohio
Research Site, Toledo, Ohio
Research Site, Norman, Oklahoma
Research Site, Hershey, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Providence, Rhode Island
Research Site, Sioux Falls, South Dakota
Research Site, Memphis, Tennessee
Research Site, Memphis, Tennessee
Research Site, Memphis, Tennessee
Research Site, Nashville, Tennessee
Research Site, Austin, Texas
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Denton, Texas
Research Site, Fort Worth, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Kingwood, Texas
Research Site, San Antonio, Texas
Research Site, San Antonio, Texas
Research Site, Charlottesville, Virginia
Research Site, Fairfax, Virginia
Research Site, Richmond, Virginia
Research Site, Milwaukee, Wisconsin
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Recruiting
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease.
Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable).
This study will have five parts. Parts A and B of the study will find out how much PF-0804605... Read More
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease.
Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable).
This study will have five parts. Parts A and B of the study will find out how much PF-08046054/SGN- PDL1V should be given to participants. Part C will use the dose found in Parts A and B to find out how safe PF-08046054/SGN-PDL1V is and if it works to treat solid tumor cancers. In Part D and E, participants will be given PF-08046054/SGN-PDL1V with pembrolizumab to find out how safe this combination is and if it works to treat solid tumor cancers. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +46 locations
University of Alabama at Birmingham, Birmingham, Alabama
University of Alabama at Birmingham, IDS Pharmacy, Birmingham, Alabama
University of Alabama at Birmingham, Birmingham, Alabama
University of California Davis Comprehensive Cancer Center, Sacramento, California
University of California, Davis Medical Center, Sacramento, California
University of Iowa Hospitals & Clinics, Iowa City, Iowa
Karmanos Cancer Institute, Detroit, Michigan
Karmanos Cancer Institute, Farmington Hills, Michigan
University Hospitals Cleveland Medical Center, Cleveland, Ohio
The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas
START Mountain Region, West Valley City, Utah
NEXT Virginia, Fairfax, Virginia
Institut Jules Bordet, Anderlecht, Not set
University Health Network, Princess Margaret Hospital, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing
Beijing Cancer Hospital, Beijing, Beijing
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Shanghai East Hospital, Shanghai, Shanghai
Hôpital Saint André - CHU Bordeaux, BORDEAUX Cedex, Not set
Clinique Ambroise Pare, Neuilly sur seine, Not set
Institut Curie, Paris Cedex 05, Not set
lnstitut Curie Pharmacy, Paris, Not set
Gustave Roussy Institute - Service pharmacie, Villejuif, Not set
Charite Universitatsmedizin Berlin, Berlin, Not set
Apotheke-Zytostatika Studien Charite- Universitatsmedizin Berlin Campus Virchow Klinkum, Berlin, Not set
Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative lstituto Europeo di Oncologia, Milano, Milan
Centro Ricerche Cliniche di Verona s.r.l. c/o Policlinico G.B Rossi, Verona, Other
Azienda Ospedaliera Universitaria Integrata Verona - Policlinico G.B Rossi, Verona, Veneto
UOC Oncologia - IRCCS Azienda Ospedaliero Universitaria Bologna, Bologna, Not set
National Cancer Center Hospital East, Kashiwa, Chiba
Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka
The Netherlands Cancer Institute, Amsterdam, Not set
CETIR Viladomat, Barcelona, Other
Hospital Duran I Reynals-Institut Català d'Oncologia L'Hospitalet (ICO L'Hospitalet), Barcelona, Other
Hospital Quiron Salud Barcelona, Barcelona, Not set
NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
START Madrid - CIOCC - Hospital Universitario HM Sanchinarro, Madrid, Not set
Diagnostic Centre, London, Others
The Harley Street Clinic (THSC), London, Other
Pharmacy: Royal Marsden Hospital, Sutton, Surrey
Royal Marsden Hospital, Sutton, Surrey
Sarah Cannon Research Institute, London, Not set
Radiology, London, Not set
Conditions: Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Ovarian Neoplasms, Melanoma, Triple Negative Breast Neoplasms, Gastric Cancer
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Recruiting
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Southern Cancer Center, PC, Daphne, Alabama +122 locations
Southern Cancer Center, PC, Daphne, Alabama
Clearview Cancer Institute, Huntsville, Alabama
Cancer Treatment Center of America Phoenix, Goodyear, Arizona
City of Hope Corona, Corona, California
City of Hope, Duarte, California
Providence Medical Foundation, Fullerton, California
The Oncology Institute of Hope and Innovation, Glendale, California
Oncology Physicians Network Healthcare, Glendale, California
Los Angeles Cancer Network, Glendale, California
Glendale Adventist Medical Center, Glendale, California
Marin Cancer Center, Greenbrae, California
City of Hope Seacliff, Huntington Beach, California
City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California
University of California San Diego Health, La Jolla, California
City of Hope Antelope Valley, Lancaster, California
City of Hope Long Beach Elm, Long Beach, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
USC Norris Comprehensive Cancer Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valkyrie Clinical Trials, Los Angeles, California
Valkyrie Clinical Trials, Murrieta, California
Kaiser Permanente Oakland Medical Center, Oakland, California
St. Joseph Hospital Center for Cancer Prevention and Treatment, Orange, California
University of California Irvine, Orange, California
Kaiser Permanente Roseville Medical Center, Roseville, California
Sutter Institute for Medical Research, Sacramento, California
Kaiser Permanente San Francisco Medical Center, San Francisco, California
UCSF Zuckerberg San Francisco General Hospital, San Francisco, California
Sansum Clinic, Santa Barbara, California
Kaiser Permanente Santa Clara Medical Center, Santa Clara, California
Providence Medical Foundation, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
City of Hope Upland, Upland, California
Kaiser Permanente Northern California, Vallejo, California
Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, California
John Muir Health Clinical Research Center, Walnut Creek, California
Saint Josephs Hospital Cancer Centers of Colorado, Denver, Colorado
Lutheran Hospital Cancer Centers of Colorado, Golden, Colorado
Rocky Mountain Cancer Centers, Lone Tree, Colorado
Yale New Haven Hospital Yale Cancer Center, New Haven, Connecticut
ChristianaCare Helen F Graham Cancer Center and Research Institute, Newark, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Washington DC VA Medical Center, Washington, District of Columbia
Baptist Lynn Cancer Institute, Boca Raton, Florida
The Oncology Institute of Hope and Innovation, Fort Lauderdale, Florida
Florida Cancer Specialists, Fort Myers, Florida
AdventHealth Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Florida Cancer Specialists & Research Institute, Saint Petersburg, Florida
Moffitt Cancer Center, Tampa, Florida
Florida Cancer Specialists & Research Institute, West Palm Beach, Florida
University Cancer And Blood Center LLC, Athens, Georgia
Grady Health System Correll Pavilion, Atlanta, Georgia
Piedmont Healthcare, Atlanta, Georgia
Piedmont Cancer Institute, Atlanta, Georgia
Winship Cancer Institute Emory University, Atlanta, Georgia
City of Hope Cancer Center, Newnan, Georgia
University of Illinois at Chicago, Chicago, Illinois
Cancer Care Specialists of Central Illinois, Decatur, Illinois
Hope and Healing Cancer Services, Hinsdale, Illinois
Illinois Cancer Specialists, Niles, Illinois
City of Hope Chicago, Zion, Illinois
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
Investigative Clinical Research of Indiana, LLC, Noblesville, Indiana
Accellacare of McFarland, Ames, Iowa
Maryland Oncology Hematology P A, Silver Spring, Maryland
Boston University Medical Center, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts
Trinity Health St Joseph Mercy Ann Arbor, Ypsilanti, Michigan
University Of Minnesota, Minneapolis, Minnesota
Jackson Oncology Associates, Jackson, Mississippi
Truman Medical Ctr West, Kansas City, Missouri
Washington University School Of Medicine, Saint Louis, Missouri
Oncology Hematology Associates, Springfield, Missouri
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Hunterdon Hematology Oncology, Flemington, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Overlook Medical Center, Summit, New Jersey
Holy Name Medical Center, Teaneck, New Jersey
University of New Mexico, Albuquerque, New Mexico
Montefiore Medical Center, Bronx, New York
Hematology-Oncology Associates of CNY, East Syracuse, New York
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York
NYU Langone Health Laura and Isaac Perlmutter Cancer Center, New York, New York
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York, New York
Ellis Hospital, Schenectady, New York
New York Cancer and Blood Specialists, Shirley, New York
Clinical Research Alliance Inc, Westbury, New York
Regional Medical Oncology Center, Wilson, North Carolina
University of Cincinnati, Cincinnati, Ohio
Oncology Associates of Oregon PC Willamette Valley Cancer Institute, Eugene, Oregon
Oregon Health And Science University, Portland, Oregon
Lankenau Institute for Medical Research Main Line Health Bryn Mawr Hospital, Bryn Mawr, Pennsylvania
Lankenau Institute for Medical Research Main Line Health Paoli Hospital, Paoli, Pennsylvania
Philadelphia VA Medical Center, Philadelphia, Pennsylvania
McGlinn Cancer Institute Reading Hospital, West Reading, Pennsylvania
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania
Avera Medical Group, Sioux Falls, South Dakota
Tennessee Oncology, Chattanooga, Tennessee
Tennessee Cancer Specialists, Knoxville, Tennessee
University of Tennessee, Knoxville, Tennessee
Baptist Cancer Center, Memphis, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
Texas Oncology DFW, Dallas, Texas
UT Southwestern Medical Center, Dallas, Texas
Renovatio Clinical, El Paso, Texas
JPS Health Network, Fort Worth, Texas
MD Anderson Cancer Center, Houston, Texas
Oncology Consultants Texas, Houston, Texas
Community Clinical Trials, Kingwood, Texas
Texas Oncology Odessa-West Texas Cancer Center, Odessa, Texas
Renovatio Clinical, The Woodlands, Texas
The University of Texas Health Science Center at Tyler, Tyler, Texas
Texas Oncology-Gulf Coast, Webster, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
Virginia Cancer Specialists, Fairfax, Virginia
Vista Oncology, Olympia, Washington
Summit Cancer Centers, Spokane, Washington
Northwest Cancer Specialists - Vancouver, Vancouver, Washington
Auxilio Mutuo Cancer Center, San Juan, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
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