There are currently 52 active clinical trials seeking participants for Chronic Kidney Diseases research studies. The states with the highest number of trials for Autism participants are California, Florida, Texas and North Carolina.
Bone in CKD Alkali Response (BICARb Pilot Trial)
NCT05918029
Recruiting
The goal of this clinical trial is to test whether potassium citrate improves skeletal health in adults and children with chronic kidney disease. The main questions it aims to answer are: To evaluate effects of potassium citrate treatment on bone quality and strength. To evaluate mechanism(s) underlying the effects of potassium citrate on skeletal health. Participants will be asked to: provide blood, urine and answer questions about health and diet three times during an 8 months period underg... Read More
Gender:
All
Ages:
Between 5 years and 100 years
Trial Updated:
01/31/2024
Locations: Albert Einstein College of Medicine, Bronx, New York +1 locations
Conditions: Chronic Kidney Diseases, Bone Loss
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Immunological Tolerance in Patients With Mismatched Kidney Transplants
NCT05806749
Recruiting
This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3 antigen (at A, B, C, DR) HLA mismatched unrelated living donor kidney and hematopoietic stem cell transplantation.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
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Mixed-Methods Study of Multidimensional Adversity in Inner-City African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
NCT05692388
Recruiting
The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in African American adults with diabetic kidney disease (DKD) experiencing multidimensional adversity (MDA) and living in the inner-city.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/16/2024
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Diabetic Nephropathy Type 2 - Uncontrolled, Diabetes Mellitus, Type 2, Chronic Kidney Diseases
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Optimizing In-hospital Use of Evidence-based Therapies for Patients With Cardio-Renal-Metabolic Disease
NCT05781334
Recruiting
This study will be a prospective randomized implementation trial for patients hospitalized with heart failure, chronic kidney disease, and/or type 2 diabetes mellitus within Duke University Medical Center. The primary hypothesis is that a virtual quality improvement-based consult intervention will improve the rate of in-hospital evidence-based cardio-renal-metabolic medication use, particularly SGLT2 inhibitor therapy. Approximately 200 patients meeting eligibility criteria will be included in t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Heart Failure, Type 2 Diabetes, Chronic Kidney Diseases
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A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
NCT05342623
Recruiting
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in advanced chronic kidney disease (CKD) patients with moderate-to-severe pruritus. This study is comprised of an Efficacy Assessment Phase and a Long-term Extension Phase. The Efficacy Assessment Phase includes a double-blind 12-week Treatment Period (Treatment Period 1),... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
01/02/2024
Locations: Cara Therapeutics Study Site, Huntsville, Alabama +82 locations
Conditions: Chronic Kidney Diseases, Pruritus
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CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
NCT05356403
Recruiting
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in advanced chronic kidney disease (CKD) patients with moderate-to-severe pruritus. This study is comprised of an Efficacy Assessment Phase and a Long-term Extension Phase. The Efficacy Assessment Phase includes a double-blind 12-week Treatment Period (Treatment Period 1),... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
01/02/2024
Locations: Cara Therapeutics Study Site, Northridge, California +76 locations
Conditions: Chronic Kidney Diseases, Pruritus
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A Study of Participants With Chronic Kidney Disease Previously Treated With REACT
NCT05694169
Recruiting
The purpose of this study is to evaluate the safety of supplemental REACT injections in participants with chronic kidney disease (CKD) who have previously received REACT treatment.
Gender:
All
Ages:
Between 30 years and 80 years
Trial Updated:
12/19/2023
Locations: Boise kidney and Hypertension Institute, Boise, Idaho
Conditions: Diabetic Kidney Disease, CAKUT, Chronic Kidney Diseases
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Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
NCT04984226
Recruiting
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.
Gender:
All
Ages:
Between 21 years and 85 years
Trial Updated:
11/27/2023
Locations: University of California Davis Health, Sacramento, California +1 locations
Conditions: Chronic Kidney Diseases, Metabolic Acidosis, Fatigue, Physical Endurance, Insulin Resistance, Mitochondrial Energetics, Diabetes
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Diuretic Tuner Clinical Decision Support
NCT04759274
Recruiting
This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information int... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/21/2023
Locations: University of Texas Southwestern, Dallas, Texas
Conditions: Edema, Hypervolemia, Chronic Kidney Diseases, Nephrotic Syndrome
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Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
NCT05719714
Recruiting
The goal of this study is to better understand the effects of a sodium-glucose transport protein 2 inhibitor, dapagliflozin, added on to standard of care on heart and lung function and circulating metabolites (substances created when our bodies break down food, drugs, or its own tissues) in patients with chronic kidney disease.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/14/2023
Locations: Northwestern University, Chicago, Illinois
Conditions: Chronic Kidney Diseases, Heart Failure With Preserved Ejection Fraction, Kidney Diseases, Heart Failure
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Sex Hormone and Vascular Function in Women With CKD
NCT05471518
Recruiting
The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in the field of nephrology focuses on male patients, and studies on women's vascular health are limited. Moreover, endogenous sex hormones, particularly estradiol, are well-documented to be cardiop... Read More
Gender:
Female
Ages:
Between 18 years and 75 years
Trial Updated:
11/08/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Chronic Kidney Diseases
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Acute Equol Supplementation and Vascular Function in Women With and Without CKD
NCT06128278
Recruiting
The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD... Read More
Gender:
Female
Ages:
Between 50 years and 69 years
Trial Updated:
11/07/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Chronic Kidney Diseases
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