There are currently 196 active clinical trials seeking participants for Colorectal Cancer research studies. The states with the highest number of trials for Colorectal Cancer participants are California, Illinois, Ohio and New York.
Real-time Computer-Aided Detection of Colonic Adenomas With NEC WISE VISION® Endoscopy
NCT05611151
Recruiting
This is a prospective, multicenter, randomized study to evaluate the clinical performance of a novel CADe device, WISE VISION® Endoscopy System, in patients undergoing high-definition white light (HDWL) colonoscopy for screening or surveillance of colorectal Cancer (CRC). Eligible subjects who meet the study inclusion/exclusion criteria will be randomized in a 1:1 ratio to undergo colonoscopy : Experimental: CADe colonoscopy procedure with WISE VISION® Endoscopy (CADe Group) Control: Standard... Read More
Gender:
All
Ages:
Between 45 years and 75 years
Trial Updated:
03/19/2024
Locations: Kansas City VA Hospital, Kansas City, Missouri +4 locations
Conditions: Colorectal Cancer, Adenoma Colon, Polyp of Colon
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Study of XL092 + Atezolizumab vs Regorafenib in Subjects With Metastatic Colorectal Cancer
NCT05425940
Recruiting
This is a multicenter, randomized, open-label, controlled Phase 3 trial of XL092 + atezolizumab vs regorafenib in subjects with microsatellite stable/microsatellite instability low (MSS/MSI-low) metastatic colorectal cancer (mCRC) who have progressed during, after or are intolerant to standard-of-care (SOC) therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Exelixis Clinical Site #65, Jonesboro, Alabama +132 locations
Conditions: Colorectal Cancer
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Stage II/III Colorectal Cancer Recurrence
NCT06314958
Recruiting
This study will develop an assay to predict disease recurrence in patients with stage II/III CRC after receiving adjuvant chemotherapy, using genome-wide DNA methylation.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: City of Hope Medical Center, Monrovia, California +3 locations
Conditions: Colorectal Cancer, Colorectal Adenocarcinoma, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Cancer Recurrent
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Predicting Local and Distant Recurrence in T1 Colorectal Cancer
NCT06314971
Recruiting
Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC. This study seeks to improve the prediction of recurrence-free survival in individuals who have survived T1 CRC.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: City of Hope Medical Center, Duarte, California +2 locations
Conditions: Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I, Colorectal Neoplasms Malignant, Colorectal Cancer Recurrent
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Walnuts and Colon Health
NCT05195970
Recruiting
The purpose of this research study is to examine whether adding walnuts to your diet can have a beneficial effect on the gut bacteria population, inflammatory markers in the blood, and the tissue that lines the inside of the colon.
Gender:
All
Ages:
Between 39 years and 75 years
Trial Updated:
03/15/2024
Locations: UConn Health, Farmington, Connecticut +1 locations
Conditions: Colorectal Cancer, Diet Habit
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A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
NCT05411718
Recruiting
To learn about the effects of naproxen and aspirin on the normal colon in people with Lynch Syndrome.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: T Cells, Colorectal Cancer, Lynch Syndrome
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First in Human Study of TORL-3-600 in Participants With Advanced Cancer
NCT05948826
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-3-600 in patients with advanced cancer
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: UCLA - JCCC Clinical Research Unit, Los Angeles, California +4 locations
Conditions: Advanced Solid Tumor, Colorectal Cancer
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Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
NCT02584244
Recruiting
The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
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Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
NCT03965234
Recruiting
This phase I/II trial studies the side effects of pulmonary suffusion in controlling minimal residual disease in patients with sarcoma or colorectal carcinoma that has spread to the lungs. Pulmonary suffusion is a minimally invasive delivery of chemotherapeutic agents like cisplatin to lung tissues. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreadin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung, Metastatic Soft Tissue Sarcoma, Metastatic Unresectable Sarcoma, Resectable Sarcoma, Colorectal Cancer
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SafeHeal Diverting Ileostomy Pivotal Study
NCT06152276
Recruiting
This SafeHeal study is designed to assess the overall safety of the low anterior resection (LAR) standard of care cancer treatment by establishing a definition of major complications. The current literature on standard of care reports adverse events/complications but does not provide a single endpoint that can be used to compare the safety of LAR cancer treatment to alternative therapies or treatments. This study will allow for the establishment of a new single safety endpoint for LAR standard o... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: UMass Memorial Medical Center, Worcester, Massachusetts +2 locations
Conditions: Colorectal Cancer, Stoma Ileostomy
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Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas
NCT04920032
Recruiting
This is a phase 1b, prospective, single arm, non-randomized, open-label clinical trial determining the efficacy of adjuvant trifluridine and tipiracil (TAS-102) in combination with irinotecan in patients with ctDNA positive colon adenocarcinoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/01/2024
Locations: Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California
Conditions: Colon Adenocarcinoma, Colorectal Cancer
Register for Updates
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
NCT03526835
Recruiting
This is a Phase 1/2 open-label, multi-center, multi-national study with an initial dose escalation part to determine the RP2D of MCLA-158 single agent in patients with mCRC. The dose escalation part has been completed and the RP2D will be further evaluated in an expansion part of the study. Cohorts of selected solid tumor indications for which there is evidence of EGFR dependency and potential sensitivity to EGFR inhibition will be evaluated including head and neck cancer. The study will furth... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/01/2024
Locations: UCSD, La Jolla, California +38 locations
Conditions: Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer, NSCLC, HNSCC, Head and Neck Squamous Cell Carcinoma
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