There are currently 54 active clinical trials seeking participants for Leukemia research studies. The states with the highest number of trials for Autism participants are California, New York, Illinois and Texas.
Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia
NCT05645718
Recruiting
To learn if cyclophosphamide, vincristine, and dexamethasone (called mini hyper-CVD) in combination with intrathecal (delivered into the spine) chemotherapy (methotrexate, hydrocortisone, cytarabine) and compressed rituximab, blinatumomab, and inotuzumab ozogamicin (called cRIB) can help to control the disease.
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
02/13/2024
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Leukemia
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Phase II Study to Evaluate Safety and Efficacy of CB-103 With Venetoclax in Adolescent and Young Adult Patients With Relapsed/Refractory T-ALL or T-LBL
NCT05464836
Recruiting
To learn if the combination of 2 study drugs, CB-103 and venetoclax, can help to control T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic leukemia (T-LBL) in adolescent and young adult patients
Gender:
All
Ages:
Between 12 years and 60 years
Trial Updated:
02/08/2024
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Leukemia, Lymphoblastic, Leukemia
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Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors
NCT06053268
Recruiting
This study will explore feasibility and acceptability of using a daily mobile mindfulness app to cope with stress. In addition, feasibility of digital health data collection procedures including wrist-worn devices and ecological momentary assessments will be examined. PRIMARY OBJECTIVES Determine the feasibility and acceptability of completing the 30-day mobile mindfulness program Evaluate the feasibility of digital health data collection procedures to detect autonomic nervous system (ANS) act... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Leukemia, Lymphoma, Childhood Cancer
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Collecting and Storing Tissue From Young Patients With Cancer
NCT00898755
Recruiting
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
Gender:
All
Ages:
21 years and below
Trial Updated:
01/29/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +68 locations
Conditions: Acute Lymphoblastic Leukemia, Rhabdomyosarcoma, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Soft Tissue Sarcoma
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Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia
NCT00357565
Recruiting
RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response agai... Read More
Gender:
All
Ages:
3 years and below
Trial Updated:
01/25/2024
Locations: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
Conditions: Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Secondary Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts in Transformation, Refractory Anemia With Excess Blasts, Refractory Anemia, De Novo Myelodysplastic Syndrome, Childhood Myelodysplastic Syndrome
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Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy
NCT05763563
Recruiting
The purpose of the study is to evaluate an exercise program for individuals preparing for Chimeric Antigen Receptor (CAR) T-cell immunotherapy for hematological malignancies.
Gender:
All
Ages:
65 years and above
Trial Updated:
01/24/2024
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Lymphoma, Leukemia, Myeloma
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Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
NCT00582621
Recruiting
The purpose of this study is to better understand the genetic causes of Hodgkin's disease (a kind of lymphoma) and non-Hodgkin's lymphoma, as well as multiple myeloma, leukemia, and related diseases. The doctors have identified the patient because 1) they have had a lymphoproliferative disorder such as lymphoma, leukemia, or multiple myeloma, and have a family member with one of these disorders or 2) they are a member of a family with a lymphoproliferative disorder, including Hodgkin's disease a... Read More
Gender:
All
Ages:
All
Trial Updated:
01/19/2024
Locations: Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey +5 locations
Conditions: Lymphoma, Leukemia, Multiple Myeloma, Colon Cancer, Renal Cancer
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Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
NCT01515527
Recruiting
The goal of this clinical research study is to learn if cladribine given in combination with low-dose cytarabine (LDAC) and decitabine can help control the disease in patients with AML or MDS. The safety of this drug combination will also be studied. Cladribine is designed to interfere with the cell's ability to process DNA (the genetic material of cells). It can also insert itself into the DNA of cancer cells to stop them from growing and repairing themselves. Cytarabine is designed to insert... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
01/11/2024
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Leukemia
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Wearable Sensors and Molecular Omics to Detect and Mitigate Cell Therapy Adverse Events
NCT05123001
Recruiting
The purpose of this study is to monitor physiological and molecular changes during and following CAR-T cancer cell therapy, towards improved management of adverse events including Cytokine Release Syndrome and neurotoxicity. Our study aims are to improved early detection and precise management of adverse events for patients receiving Chimeric antigen receptor T- cell (CAR-T): To assess the feasibility, including accuracy, usability, and usefulness of wearable sensors in CAR-T patients. To gene... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/10/2024
Locations: Stanford University, Palo Alto, California
Conditions: Hodgkin Lymphoma, Non Hodgkin Lymphoma, Leukemia, Multiple Myeloma
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Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
NCT02356653
Recruiting
The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is indicated. These patients are not eligible for other Children's Hospital of Philadelphia IRB approved protocols that utilize CliniMACs technology for T depletion.
Gender:
All
Ages:
30 years and below
Trial Updated:
12/19/2023
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Leukemia, Inborn Errors of Metabolism, Bone Marrow Failure Syndromes, Immunodeficiencies, Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome
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Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies
NCT02323867
Recruiting
This is a single arm pilot study for patients using α/β T cell-depleted peripheral Stem Cell Transplantation (PSCT) in with alternative donor sources with hematologic malignancies receiving alternative donor (unrelated or partially matched related) mobilized peripheral stem cells (PSCs) using the CliniMACS system for T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and graft versus host disease (GVHD), and one year leukemia free survival.
Gender:
All
Ages:
23 years and below
Trial Updated:
12/19/2023
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Leukemia, Lymphoma, Myelodysplasia
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Improving Communication and Building a Stronger Medical Home Among Spanish-speaking Families
NCT05425992
Recruiting
This study will seek to improve communication with Spanish speaking families and patients with Cancer and Blood Disorders.
Gender:
All
Ages:
22 years and below
Trial Updated:
12/08/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Leukemia, Non Hodgkin Lymphoma
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