Metastatic Cancer Clinical Trials

A listing of 57 Metastatic Cancer clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 57 active clinical trials seeking participants for Metastatic Cancer research studies. The states with the highest number of trials for Metastatic Cancer participants are California, Ohio, Michigan and Illinois.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Research Study

Recruiting

Are you tired of living with chronic cough? Our research study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough.
You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you!

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Sinusitis

Learn More

Featured Offer

Lose Weight with GLP-1 Medications

Recruiting

Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.

GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.

As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.

Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Featured Trial

Stroke Clinical Study

Recruiting

A clinical study for people that suffer with Stroke

Conditions:

Stroke

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A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

NCT05378425

Recruiting

This is a Phase 1,open-label, multi-center, first-in-human, 2-part (Part 1: dose escalation and Part 2: expansion) study, evaluating multiple doses and schedules of intravenously (IV) administered NTX-1088, with or without pembrolizumab, in patients with advanced solid malignancies (i.e., locally advanced or metastatic).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/24/2025

Locations: City of Hope, Duarte, California +5 locations

Conditions: Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer, Locally Advanced Solid Tumor

Learn More ›

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

NCT03785249

Recruiting

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/14/2025

Locations: ONeal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, Alabama +227 locations

ONeal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, Alabama

Alaska Oncology and Hematology, Anchorage, Alaska

Mayo Clinic Arizona - Phoenix Campus, Phoenix, Arizona

Local Institution - 001-807, Scottsdale, Arizona

Local Institution - 001-873-A, Tucson, Arizona

USOR - Arizona Oncology - Tucson - Rudasill, Tucson, Arizona

Local Institution - 001-840-B, Bellflower, California

Beverly Hills Cancer Center, Beverly Hills, California

City of Hope - Duarte (Main Campus), Duarte, California

Local Institution - 001-850-K, Dublin, California

Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton, Fullerton, California

Local Institution - 001-840-C, Harbor City, California

University of California San Diego Moores Cancer Center, La Jolla, California

TRIO - Cancer and Blood Specialty Clinic, Los Alamitos, California

Southern California Permanente Medical Group - Los Angeles Medical Center, Los Angeles, California

Valkyrie Clinical Trials, Los Angeles, California

Hoag Memorial Hospital Presbyterian - Newport Beach, Newport Beach, California

Local Institution - 001-850-B, Oakland, California

University of California Irvine Medical Center, Orange, California

Local Institution - 001-850-C, Roseville, California

Local Institution - 001-850-J, Sacramento, California

Local Institution - 001-850-D, Sacramento, California

California Cancer Associates for Research and Excellence (cCARE) - San Diego 4S Ranch, San Diego, California

Local Institution - 001-840-A, San Diego, California

Local Institution - 001-850-H, San Francisco, California

Local Institution - 001-850-E, San Francisco, California

Local Institution - 001-850-F, San Jose, California

Local Institution - 001-850-A, San Leandro, California

Ridley - Tree Cancer Center - Santa Barbara, Santa Barbara, California

Local Institution - 001-850-I, Santa Clara, California

Local Institution - 001-884-A, Solvang, California

Kaiser Permanente - Vallejo Medical Center, Vallejo, California

Local Institution - 001-850-G, Walnut Creek, California

USOR - Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado

UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center, Aurora, Colorado

Local Institution - 001-872-H, Boulder, Colorado

Local Institution - 001-872-E, Colorado Springs, Colorado

Local Institution - 001-872-L, Colorado Springs, Colorado

Local Institution - 001-872-B, Denver, Colorado

Local Institution - 001-951 - A, Denver, Colorado

Local Institution - 001-951 - B, Denver, Colorado

Cancer Centers of Colorado - St. Marys Regional Hospital, Grand Junction, Colorado

SCL Health - Saint Joseph Hospital Cancer Center, Lafayette, Colorado

Local Institution - 001-872-A, Lakewood, Colorado

Local Institution - 001-872-D, Littleton, Colorado

Local Institution - 001-872-K, Lone Tree, Colorado

Local Institution - 001-872-C, Longmont, Colorado

Local Institution - 001-872-J, Parker, Colorado

Local Institution - 001-872-F, Pueblo, Colorado

Local Institution - 001-872-G, Pueblo, Colorado

Local Institution - 001-872-I, Thornton, Colorado

Yale Cancer Center, New Haven, Connecticut

USOR - Medical Oncology Hematology Consultants, Newark, Delaware

Local Institution - 001-929i, Altamonte Springs, Florida

Boca Raton Clinical Research Associates, Inc., Boca Raton, Florida

Local Institution - 001-922A, Bonita Springs, Florida

Local Institution - 001-922D, Bradenton, Florida

Local Institution - 001-929c, Brandon, Florida

Local Institution - 001-922E, Cape Coral, Florida

Local Institution - 001-929g, Clearwater, Florida

Local Institution - 001-926b, Daytona Beach, Florida

SCRI - Florida Cancer Specialists - South Region Research Office, Fort Myers, Florida

Local Institution - 001-922B, Fort Myers, Florida

Local Institution - 001-922C, Fort Myers, Florida

Local Institution - 001-929b, Gainesville, Florida

Mayo Clinic - Jacksonville, Jacksonville, Florida

Local Institution - 001-929m, Lady Lake, Florida

Local Institution - 001-929e, Largo, Florida

Local Institution - 001-929n, Lecanto, Florida

Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida

Miami Cancer Institute, Miami, Florida

Local Institution - 001-922F, Naples, Florida

Local Institution - 001-922G, Naples, Florida

Florida Cancer Affiliates - Ocala - Main, Ocala, Florida

Local Institution - 001-929p, Ocala, Florida

Local Institution - 001-929j, Orange City, Florida

Mid Florida Cancer Centers - Orange City, Orange City, Florida

Local Institution - 001-929l, Orlando, Florida

Woodlands Medical Specialists, Pensacola, Florida

Local Institution - 001-922H, Port Charlotte, Florida

Local Institution - 001-929a, Saint Petersburg, Florida

SCRI - Florida Cancer Specialists - North Region Research Office, Saint Petersburg, Florida

Local Institution - 001-922I, Sarasota, Florida

Local Institution - 001-922J, Sarasota, Florida

Local Institution - 001-929h, Spring Hill, Florida

Local Institution - 001-926d, Stuart, Florida

Local Institution - 001-929d, Tampa, Florida

Local Institution - 001-929k, Tavares, Florida

Local Institution - 001-929f, Trinity, Florida

Local Institution - 001-922K, Venice, Florida

Local Institution - 001-922L, Venice, Florida

Local Institution - 001-926c, Vero Beach, Florida

Local Institution - 001-926a, Wellington, Florida

SCRI - Florida Cancer Specialists - East Region Research Office, West Palm Beach, Florida

Local Institution - 001-929o, Winter Park, Florida

University Cancer & Blood Center (UCBC) - Athens, Athens, Georgia

Local Institution - 001-835-C, Austell, Georgia

Local Institution - 001-835-E, Austell, Georgia

Local Institution - 001-835-D, Carrollton, Georgia

Local Institution - 001-835-F, Carrollton, Georgia

Local Institution - 001-835-A, Cartersville, Georgia

Local Institution - 001-835-B, Douglasville, Georgia

Northwest Georgia Oncology Centers Wellstar - Marietta, Marietta, Georgia

Affiliated Oncologists, LLC, Chicago Ridge, Illinois

Local Institution - 001-828, Chicago, Illinois

USOR - Illinois Cancer Specialists - Niles, Niles, Illinois

Memorial Hospital, South Bend, Indiana

University of Iowa, Iowa City, Iowa

University of Kansas Medical Center, Westwood, Kansas

University of Kentucky, Lexington, Kentucky

SCRI - Hematology Oncology Clinic - Baton Rouge, Baton Rouge, Louisiana

MaineHealth Cancer Care - Biddeford, Biddeford, Maine

Local Institution - 001-881-B, Brandywine, Maryland

Maryland Oncology Hematology - Columbia, Columbia, Maryland

Local Institution - 001-881-A, Silver Spring, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Health System, Detroit, Michigan

Local Institution - 001-842-A, Farmington Hills, Michigan

Local Institution - 001-838-F, Coon Rapids, Minnesota

Local Institution - 001-838-E, Edina, Minnesota

Local Institution - 001-875 - D, Edina, Minnesota

Local Institution - 001-838-D, Maplewood, Minnesota

Local Institution - 001-875 - A, Maplewood, Minnesota

Local Institution - 001-838-C, Minneapolis, Minnesota

USOR - Minnesota Oncology - Minneapolis Clinic, Minneapolis, Minnesota

Local Institution - 001-838-G, Minneapolis, Minnesota

Local Institution - 001-822-A, Minneapolis, Minnesota

Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic - Rochester, Rochester, Minnesota

Metro-Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park, Minnesota

Local Institution - 001-838-B, Saint Louis Park, Minnesota

Local Institution - 001-838-A, Saint Paul, Minnesota

Local Institution - 001-875 - B, Saint Paul, Minnesota

Local Institution - 001-875 - C, Woodbury, Minnesota

Central Care Cancer Center - Bolivar, Bolivar, Missouri

Goldschmidt Cancer Center, Jefferson City, Missouri

Sisters of Charity of Leavenworth Health St. Marys, Billings, Montana

Local Institution - 001-544B, Omaha, Nebraska

Methodist Estabrook Cancer Center, Omaha, Nebraska

Local Institution - 001-544A, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Local Institution - 001-860A, Henderson, Nevada

Local Institution - 001-860C, Henderson, Nevada

Local Institution - 001-860B, Henderson, Nevada

USOR - Comprehensive Cancer Centers of Nevada - Southeast Henderson, Henderson, Nevada

Local Institution - 001-860E, Las Vegas, Nevada

Local Institution - 001-860D, Las Vegas, Nevada

Local Institution - 001-860F, Las Vegas, Nevada

New York Oncology Hematology - Albany Medical Center, Albany, New York

Roswell Park Comprehensive Cancer Center, Buffalo, New York

Local Institution - 001-832, Lake Success, New York

Perlmutter Cancer Center - 34th Street, New York, New York

Local Institution - 001-583, New York, New York

Memorial Sloan Kettering Cancer Center - New York, New York, New York

University of North Carolina Hospitals, Chapel Hill, North Carolina

FirstHealth Outpatient Cancer Center, Pinehurst, North Carolina

The Christ Hospital, Cincinnati, Ohio

University of Cincinnati Health Barrett Cancer Center, Cincinnati, Ohio

Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio

Local Institution - 001-833 - H, Columbus, Ohio

Local Institution - 001-833 - C, Columbus, Ohio

Local Institution - 001-833 - J, Columbus, Ohio

Local Institution - 001-833 - A, Columbus, Ohio

Local Institution - 001-833 - F, Columbus, Ohio

The Ohio State University College of Medicine, Columbus, Ohio

Local Institution - 001-833 - D, Columbus, Ohio

Local Institution - 001-833 - I, Columbus, Ohio

SCRI - Mark H. Zangmeister Cancer Center, Columbus, Ohio

Local Institution - 001-833 - B, Columbus, Ohio

Local Institution - 001-833 - G, Columbus, Ohio

Local Institution - 001-833 - E, Gahanna, Ohio

Kettering Health Cancer Center - Main Campus, Kettering, Ohio

Local Institution - 001-836-A, Kettering, Ohio

Cancer Centers of Southwest Oklahoma - Leah M. Fitch Cancer Center, Lawton, Oklahoma

Local Institution - 001-580, Oklahoma City, Oklahoma

Local Institution - 001-584, Tulsa, Oklahoma

Local Institution - 001-586-A, Bend, Oregon

St. Charles Health System, Bend, Oregon

Willamette Valley Cancer Institute and Research Center - Eugene, Eugene, Oregon

Lehigh Valley Physician Group Hematology Oncology, Allentown, Pennsylvania

Local Institution - 001-837-A, Bethlehem, Pennsylvania

Penn State Cancer Institute, Hershey, Pennsylvania

USOR - Alliance Cancer Specialists - Media (Cancer Center at Riddle Memorial Hospital), Media, Pennsylvania

USOR - Charleston Hematology Oncology Associates, Charleston, South Carolina

Medical University of South Carolina, Charleston, South Carolina

Local Institution - 001-801-G, Gallatin, Tennessee

Local Institution - 001-801-A, Hendersonville, Tennessee

Local Institution - 001-801-D, Hermitage, Tennessee

Local Institution - 001-801-F, Murfreesboro, Tennessee

Local Institution - 001-801-B, Nashville, Tennessee

Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology, Nashville, Tennessee

Local Institution - 001-801-E, Nashville, Tennessee

Local Institution - 001-801-C, Nashville, Tennessee

Local Institution - 001-888-B, Arlington, Texas

USOR - Texas Oncology Dallas Fort Worth West (DFWW) - Arlington South, Arlington, Texas

USOR - Texas Oncology - Austin Central, Austin, Texas

Local Institution - 001-848a, Conroe, Texas

Mary Crowley Cancer Research - Medical City Hospital, Dallas, Texas

USOR - Texas Oncology - Dallas Fort Worth (DFW) - Presbyterian Cancer Center Dallas, Dallas, Texas

USOR - Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center, Dallas, Texas

USOR - Texas Oncology Northeast Texas - Denison, Denison, Texas

Texas Oncology - Dallas Fort Worth (DFW) - Fort Worth, Fort Worth, Texas

Oncology Consultants - Texas Medical Center, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Local Institution - 001-935A, Houston, Texas

Local Institution - 001-999, Irving, Texas

Local Institution - 001-935D, Kingwood, Texas

Lumi Research, Kingwood, Texas

USOR - Texas Oncology - Midland Allison Cancer Center, Midland, Texas

START Center for Cancer Care, San Antonio, Texas

Local Institution - 001-935B, Shenandoah, Texas

Local Institution - 001-935C, Spring, Texas

Texas Oncology - Sugar Land, Sugar Land, Texas

Local Institution - 001-935E, Tomball, Texas

Texas Oncology - Northeast Texas Cancer and Research Institute - Tyler, Tyler, Texas

Texas Oncology - Waco, Waco, Texas

Local Institution - 001-919, Fairfax, Virginia

NEXT Virginia, Fairfax, Virginia

Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia

USOR - Virginia Oncology Associates - Newport News, Newport News, Virginia

Local Institution - 001-882-A, Norfolk, Virginia

Local Institution - 001-890-A, Norfolk, Virginia

Virginia Cancer Institute - West End, Richmond, Virginia

Fred Hutchinson Cancer Research Center, Seattle, Washington

USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center, Vancouver, Washington

University Wisconsin Carbone Cancer Center, Madison, Wisconsin

PanOncology Trials - Rio Piedras Medical Center, San Juan, Not set

Conditions: Advanced Cancer, Metastatic Cancer, Malignant Neoplastic Disease

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FOG-001 in Locally Advanced or Metastatic Solid Tumors

NCT05919264

Recruiting

The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/10/2025

Locations: Honor Health, Scottsdale, Arizona +10 locations

Conditions: Cancer, Colorectal Cancer, Solid Tumor, Locally Advanced Solid Tumor, Metastatic Cancer, WNT Pathway, β-catenin, Beta-catenin, Adenomatous Polyposis Coli, APC, HCC, Desmoid, Microsatellite Stable Colorectal Cancer, Metastatic Castration-resistant Prostate Cancer, FAP, Endometrial Carcinoma, Prostate Cancer, Microsatellite Instability-High Colorectal Cancer, CTNNB1, Adamantinomatous Craniopharyngioma

Learn More ›

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

NCT06896162

Recruiting

This is a hybrid decentralized, single-arm, interventional study designed to evaluate the impact of precision medicine navigation and reflexive expert review of next-generation sequencing (NGS) for patients with stage IV solid tumor malignancies (breast, lung, colorectal, and bladder cancers). The purpose of this study is to investigate whether intervention from a centralized precision oncology navigator and expert review of NGS results by the precision oncology pharmacist will increase orderin... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/10/2025

Locations: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina

Conditions: Solid Tumor Malignancies, Metastatic Cancer, Breast Cancer, Colorectal Cancer, Lung Cancer, Bladder Cancer

Learn More ›

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

NCT06058988

Recruiting

The purpose of this study is to find out how much tratuzumab deruxtecan (T-DXd) can penetrate the tumor when injected into the body, and whether T-DXd may be an effective treatment for brain cancers that express the HER2 protein.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/01/2025

Locations: Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York

Conditions: Brain Cancer, Glioblastoma, Metastatic Cancer, Leptomeningeal Metastasis, Recurrent Glioblastoma

Learn More ›

Prospective Validation of a Points Score System Predicting 30-day Survival

NCT05100342

Recruiting

This is a one-stage single-arm phase II clinical trial designed to prospectively test the survival prediction tool as developed by Lee et al on patients referred to radiation oncology for palliative treatments. Survival prediction score based on objective data including laboratory values, attendance to emergency room, and primary cancer origin will be assigned to each patient at time of enrollment.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: IU Health West, Avon, Indiana +2 locations

Conditions: Metastatic Cancer

Learn More ›

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

NCT05669482

Recruiting

This study will assess the safety and efficacy of avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxel in patients with Pancreatic Ductal Adenocarcinoma (PDAC) who have been previously untreated.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/20/2025

Locations: UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California +11 locations

Conditions: KRAS Activating Mutation, Metastatic Cancer, Pancreas Cancer, Neoplasms Pancreatic, Malignant Neoplasm of Pancreas

Learn More ›

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

NCT05267626

Recruiting

This is a first in human, open-label, multi-center Phase 1 / 2 study to evaluate the safety, tolerability, and initial efficacy of AU-007 in patients with advanced solid tumors. AU-007 will be administered either as a monotherapy, or in combination with a single loading dose of aldesleukin, or with both AU-007 and aldesleukin given every 2 weeks (Q2w). Once the recommended phase 2 dose (RP2D) of AU-007 plus aldesleukin was determined, (AU-007 Q2w plus a single loading dose of aldesleukin), AU-00... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/12/2025

Locations: START Midwest, Grand Rapids, Michigan +12 locations

Conditions: Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma, Non-Small Cell Lung Cancer

Learn More ›

A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as Monotherapy or in Combination With Pembrolizumab in Adults With Metastatic or Advanced Solid Tumors

NCT05346484

Recruiting

This is an open-label, dose-escalation, multi-center phase I study evaluating the safety of CF33-hNIS (hNIS - human sodium iodide symporter) administered via two routes of administration, intratumoral (IT) or intravenous (IV), either as a monotherapy or in combination with pembrolizumab or mFOLFOX in patients with metastatic or advanced solid tumors.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/11/2025

Locations: University of Arizona Cancer Center, Tucson, Arizona +11 locations

Conditions: Solid Tumor, Solid Carcinoma, Solid Tumor, Adult, Metastatic Cancer, Advanced Solid Tumor, Cholangiocarcinoma, Bile Duct Cancer

Learn More ›

Evaluating Disparities in Precision Oncology

NCT06081517

Recruiting

This is a non-randomized observational trial designed to collect detailed clinical, social determinant, and genomic data from patients enrolled in molecular oncology tumor boards across four comprehensive cancer centers.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/10/2025

Locations: Indiana University Health Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana

Conditions: Metastatic Cancer, Advanced Cancer

Learn More ›

A Study of the ApricityCare Program for Early Detection and Management of Treatment-Related Adverse Events in Patients With Cancer

NCT06693687

Recruiting

To evaluate the rate of therapy discontinuation due to toxicity (side effects) among participants with cancer using ApricityCare. Investigators want to learn if identification of early clinical signs of irAEs with timely treatment can prevent severity progression and reduce treatment discontinuation.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/06/2025

Locations: MD Anderson Cancer Center, Houston, Texas

Conditions: Metastatic Cancer

Learn More ›

Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION)

NCT05475171

Recruiting

To learn if MGD019 can help to control cervical cancer in patients who have yet to receive treatment.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/06/2025

Locations: M D Anderson Cancer Center, Houston, Texas

Conditions: Metastatic Cancer, Cervical Cancer

Learn More ›

13 - 24 of 57