GLP-1 Medications for Weight Loss Now Available!

There are currently 44 active clinical trials seeking participants for Overweight research studies. The states with the highest number of trials for Overweight participants are California, Texas, Florida and New York.
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549
Recruiting
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/17/2025
Locations: Carey Chronis MD Pediatric, Infant and Adolescent Medicine, Ventura, California +40 locations
Conditions: Obesity, Overweight
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A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939
Recruiting
The main purpose of this study, performed under Master Protocol J4M-MC-PWMP, is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will last about 18 months.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/17/2025
Locations: Carey Chronis MD Pediatric, Infant and Adolescent Medicine, Ventura, California +44 locations
Conditions: Obesity, Overweight
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A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT06603571
Recruiting
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136 for chronic weight management alone or in combination with Tirzepatide across a wide dose range in participants with Type 2 Diabetes. Participation in the study will last about 64 weeks.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/17/2025
Locations: The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona +51 locations
Conditions: Obesity, Overweight
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Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
NCT06891352
Recruiting
In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to one of three groups: (1) dietary monitoring, (2) dietary monitoring plus 10-hour daytime time-restricted eating (TRE), or (3) TRE with a low-glycemic snack during night shifts. The study includes a 2-wee... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/14/2025
Locations: University of California San Diego Altman Clinical and Translational Research Institute, La Jolla, California
Conditions: Night Shift Work, Time Restricted Eating, Overweight, Obesity
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Piloting a Reinforcement Learning Tool for Individually Tailoring Just-in-time Adaptive Interventions
NCT05751993
Recruiting
The purpose of this pilot study is to conduct a 12-week pilot feasibility study testing usability of a reinforcement learning model (AdaptRL) in a weight loss intervention (ADAPT study). Building upon a previous just-in-time adaptive intervention (JITAI), a reinforcement learning model will generate decision rules unique to each individual that are intended to improve the tailoring of brief intervention messages (e.g., what behavior to message about, what behavior change techniques to include),... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/11/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Overweight and Obesity, Overweight, Obesity
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The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
NCT04248127
Recruiting
A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with microbial derived metabolites (SCFAs, BAs, ellagitannins), metabolism and the fecal microbiome. The above suite of selected markers will capture diet-induced systemic changes in inflammation and oxidative stress, while assessing associated microbial cha... Read More
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
03/25/2025
Locations: University of California, Davis; Department of Nutrition, Davis, California
Conditions: Overweight
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Wild Blueberries for Gut, Brain, and Heart Health in Adults with High Blood Pressure
NCT06735599
Recruiting
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
03/18/2025
Locations: Georgia State University, Atlanta, Georgia
Conditions: Hypertension (without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female, Adult, Cognition, Endothelial Function (reactive Hyperemia), Oxidative Stress, Diet, Overweight, Body Composition Measurement, Gut Microbiome, Arterial Stiffness, Caucasian Whites, Inflammation, Microvascular Function
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Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
NCT06735651
Recruiting
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
03/18/2025
Locations: Georgia State University, Atlanta, Georgia
Conditions: Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (reactive Hyperemia), Arterial Stiffness, Cognition, Oxidative Stress, Gut Microbiota, Overweight, Inflammation, Microvascular Function, Body Composition
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Improving Glycemic Control with Electrical Stimulation
NCT03947697
Recruiting
Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min/day, 3x/week) and randomized into placebo/control, NMES, resistance training combined with NMES (RT +NMES), or... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: University of Texas at El Paso, El Paso, Texas
Conditions: Obesity, Overweight, Insulin Resistance
Register for Updates
Family-Based Treatment for Type 1 Diabetes
NCT05756361
Recruiting
Type 1 Diabetes carries high burden for affected youth and their families. Advances in insulin therapy and technology have been associated with increased obesity with 1/3 adolescents being overweight/obese. Since obesity runs in families and carries risk for poor outcomes psychologically and medically, the investigators are adapting our successful evidence-based Family Based Treatment for hybrid delivery to improve obesity and metabolic control in the affected youth and improve obesity and relat... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
02/14/2025
Locations: Conventus, Buffalo, New York
Conditions: Diabetes Mellitus, Type 1, Obesity, Childhood, Overweight, Comorbidities and Coexisting Conditions
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Night Owl Metabolism
NCT06507722
Recruiting
The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo tw... Read More
Gender:
ALL
Ages:
Between 18 years and 23 years
Trial Updated:
02/11/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: PreDiabetes, Overweight, Impaired Glucose Tolerance
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Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
NCT05774665
Recruiting
The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard antidepressant treatment. The main questions it seeks to answer are: 1. Do omega-3 fatty acids added to ineffective antidepressant treatment increase production of compounds that reduce inflammation? 2. Is the increase in these anti-inflammatory compounds associated with a stron... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/31/2025
Locations: Emory University School of Medicine, Atlanta, Georgia +2 locations
Conditions: Treatment Resistant Depression, Inflammation, Overweight
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