There are currently 98 active clinical trials seeking participants for Schizophrenia research studies. The states with the highest number of trials for Schizophrenia participants are California, Florida, Texas and New York.
Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
NCT05030272
Recruiting
The study team will conduct a Multisite Randomized Controlled Trial to evaluate the advantages and disadvantages of two approaches for quitting smoking among people with serious mental illness (SMI). The study will compare a novel app tailored to people with SMI, Quit on the Go, to a standard of care smoking cessation intervention. We will test the effectiveness of the Quit on the Go app, an intervention that has demonstrated feasibility and acceptability in the target population, as a tool for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: University at Buffalo, Buffalo, New York +2 locations
Conditions: Tobacco Use Disorder, Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Recurring Major Depressive Disorder, Persistent Depressive Disorder
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Study of SPG302 in Adults With Schizophrenia
NCT06442462
Recruiting
This Phase 2 study described herein will evaluate the safety, efficacy, tolerability, and pharmacodynamics of SPG302 in adults with a primary diagnosis of schizophrenia.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/12/2025
Locations: CenExel CNS, Garden Grove, California +2 locations
Conditions: Schizophrenia
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Safety and Tolerability of Open-Labeled Iloperidone in Adolescents
NCT05648591
Recruiting
To evaluate the safety and tolerability of iloperidone in adolescent patients with schizophrenia or bipolar I disorder for up to 52 weeks of treatment.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
02/27/2025
Locations: Vanda Investigational Site, Little Rock, Arkansas +8 locations
Conditions: Schizophrenia, Bipolar I Disorder
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Enhancing Rehabilitation for Veterans With Serious Mental Illness
NCT06586164
Recruiting
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chronic functional disability, and impaired outcomes, causing a significant strain on support networks and the VA healthcare system. This study aims to introduce an innovative mental health therapy, Target... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/26/2025
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Schizophrenia, Psychosis, Serious Mental Illness, PTSD, Schizoaffective Disorder, Bipolar Disorder
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Accelerated Transcranial Magnetic Stimulation for People with Schizophrenia Treated with Clozapine
NCT06003036
Recruiting
In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that a... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
02/25/2025
Locations: UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder
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Remote State Representation in Early Psychosis
NCT05538832
Recruiting
The purpose of this study is to examine state representation in individuals aged 18-30 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundings. The investigators will complete some observational tests as well as a cognitive training clinical trial.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
02/25/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Psychosis, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Schizophreniform Disorders, Psychotic Disorders, Psychotic Mood Disorders, Psychoses, Affective, Psychosis Nos/Other, Schizophrenia Spectrum and Other Psychotic Disorders
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Enhanced Coordinated Specialty Care for Early Psychosis
NCT06071858
Recruiting
The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatment for first-episode psychosis? Participants will either: * Receive care as usual (CSC) or * Receive care as usual (CSC) plus five additional care elements (CSC 2.0): 1. Individual peer support... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/20/2025
Locations: McLean Hospital OnTrack Clinic, Belmont, Massachusetts +4 locations
Conditions: Psychosis, Schizophrenia, Schizoaffective Disorder, Psychosis Nos/Other, Bipolar Disorder
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Prebiotic Treatment in People With Schizophrenia
NCT05527210
Recruiting
The proposed project is based on the observation that schizophrenia is characterized by a chronic pro-inflammatory state, which contributes to the severity of a number of the clinical manifestations of the illness, including cognitive impairments, the treatment of which represents a critically important unmet therapeutic need.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/08/2025
Locations: Maryland Psyciatric Research Center, Catonsville, Maryland
Conditions: Schizophrenia, Schizoaffective Disorder
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Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: a Pilot Study
NCT05380583
Recruiting
The purpose of this study is to evaluate Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) for families experiencing early psychosis and substance use delivered exclusively or primarily via telehealth (video conferencing).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/06/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Psychosis, Substance Use, Substance Use Disorders, Family, Cannabis, Marijuana, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
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Anticholinergic Deprescription in Schizophrenia
NCT06562608
Recruiting
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be ran... Read More
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
02/05/2025
Locations: UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder
Register for Updates
Study to Evaluate Weight Gain As Assessed by Change in BMI Z-score in Pediatric Subjects with Schizophrenia or Bipolar I Disorder
NCT05303064
Recruiting
To compare changes in body mass index (BMI) Z-score following treatment with OLZ/SAM vs olanzapine
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
02/04/2025
Locations: Alkermes Investigator Site, Dothan, Alabama +42 locations
Conditions: Schizophrenia, Bipolar I Disorder
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Cognitive Training for Emotion Regulation in Psychotic Disorders
NCT04414215
Recruiting
The current study examines the efficacy of a cognitive training intervention for improving emotion regulation in psychotic disorders. it is hypothesized that the cognitive training program will enhance prefrontal activation, leading to enhanced emotion regulation.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/04/2025
Locations: University of Georgia, Athens, Georgia
Conditions: Schizophrenia, Schizo Affective Disorder
Register for Updates