The city of Chicago, Illinois, currently has 23 active clinical trials seeking participants for Parkinson's Disease research studies.
C-STAR Movement Database
NCT05471375
Recruiting
The purpose of this study is to develop a database that contains movement and rehabilitation-related data collected through the use of wearable sensors and video. This database will serve as a resource for clinicians and researchers interested in the investigation of movement or rehabilitation-related research ideas.
Gender:
All
Ages:
99 years and below
Trial Updated:
01/22/2024
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
NCT04477785
Recruiting
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.
Gender:
All
Ages:
30 years and above
Trial Updated:
12/13/2023
Locations: Northwestern University, Chicago, Illinois
Conditions: Parkinson Disease
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Evaluation of Correlation Between Oculometric Measures and Clinical Assessment in Parkinson's Disease
NCT05862649
Recruiting
This is a multicenter longitudinal study in about 300 patients with Idiopathic Parkinson's disease, who will be evaluated in several clinical centers with a clinical assessment and an oculometric examination during a time period with specific intervals. This study aims to evaluate the correlation between oculometric measures and clinical assessment over time, as well as the potential to detect early change in clinical status using an oculometric assessment.
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
11/13/2023
Locations: Rush University, Chicago, Illinois
Conditions: Parkinson Disease
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Automated Imaging Differentiation of Parkinsonism
NCT05913687
Recruiting
The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
11/13/2023
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Progressive Supranuclear Palsy
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A Novel Measurement Concept to Objectively Quantify Severity of Vocal and Speech Related Symptoms Associated With Parkinson's Disease
NCT05421832
Recruiting
The aim of this research program is to develop and validate a smartphone app-based digital measurement concept that: Objectively quantifies the severity of Parkinson's Disease (PD) related vocal and speech symptoms; Accurately and sensitively identifies vocal and speech abnormalities associated with the prodromal stage of PD.
Gender:
All
Ages:
30 years and above
Trial Updated:
11/08/2023
Locations: Northwestern University, Chicago, Illinois
Conditions: Parkinson Disease
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rTMS to Improve Cognition in Parkinson's
NCT03836950
Recruiting
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease who are experiencing mild problems with their thinking ability.
Gender:
All
Ages:
50 years and above
Trial Updated:
11/02/2023
Locations: Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois
Conditions: Parkinson's Disease, Mild Cognitive Impairment
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Sensory-specific Peripheral Stimulation for Tremor Management
NCT04501133
Recruiting
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons. For this purpose, the investigators will use transcutaneous PES, high-density electromyography (HD-EMG), transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and neuromusculoskeletal modelling. This study will be carried out in both healthy participants and patients... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/04/2023
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Parkinson's Disease, Essential Tremor
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Noninterventional Study Evaluating Parkinson's Disease Diary Use
NCT05363046
Recruiting
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide adequate control of symptoms.
Gender:
All
Ages:
Between 39 years and 70 years
Trial Updated:
09/12/2023
Locations: Parkinson's Disease and Movement Disorders Center at Northwestern University Feinberg School of Medicine, Chicago, Illinois
Conditions: Parkinson's Disease
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Trial of Parkinson's And Zoledronic Acid
NCT03924414
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Northwestern Medicine, Chicago, Illinois +3 locations
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease
NCT04991831
Recruiting
The objectives of this study are to collect the long-term safety and effectiveness data of performing thalamotomy for tremor dominant Parkinson's Disease (TDPD) using the Exablate Neuro system.
Gender:
All
Ages:
Between 30 years and 99 years
Trial Updated:
01/13/2023
Locations: Rush University, Chicago, Illinois
Conditions: Tremor Associated With Tremor Dominant Parkinson's Disease
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Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
NCT04857359
Recruiting
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on the Unified Dyskinesia Rating Scale (UDysRS). Patients who complete the 12-week blinded treatment period may have the option to roll into an open-label safety extension study for an additional 12-month treatment period.
Gender:
All
Ages:
Between 30 years and 85 years
Trial Updated:
05/18/2022
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
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