The state of Illinois currently has 23 active clinical trials seeking participants for Dementia research studies. These trials are conducted in various cities, including Chicago, Peoria, Springfield and Urbana.
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Recruiting
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss. Ag... Read More
Gender:
All
Ages:
Between 60 years and 90 years
Trial Updated:
02/27/2024
Locations: Rush University Medical Center & Illinois Institute of Technology, Chicago, Illinois
Conditions: Cognitive Impairment, Dementia
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
Recruiting
To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/20/2024
Locations: Advocate Lutheran General Hospital, Park Ridge, Illinois
Conditions: Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Patient-Centered Dementia Care Practice Coaching Intervention
Recruiting
The goal of this clinical trial is to compare staff outcomes in long-term care communities who participate in the intervention versus those who do not. The main questions it aims to answer are: 1. Is employee satisfaction impacted by the intervention and 2. Is dementia care confidence impacted by the intervention. Participants will include monthly coaching visits for the intervention group and completion of surveys pre, immediately post and three-months post. Researchers will compare the interve... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
02/12/2024
Locations: Alzheimer's Association, Chicago, Illinois
Conditions: Dementia, Alzheimer Disease
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Recruiting
Our study intends to offer 'real world' evidence of a viable, sustainable means to mobilize primary care via a comprehensive strategy for detecting cognitive impairment and dementias, advancing next steps for referral, and participating in the care planning and management of affected patients and caregivers. We will conduct a clinic-randomized, pragmatic trial testing the effectiveness and fidelity of our NIH Toolbox-derived paradigm to improve early detection and management of cognitive impairm... Read More
Gender:
All
Ages:
45 years and above
Trial Updated:
02/06/2024
Locations: Oak Street Health, Chicago, Illinois
Conditions: Dementia, Cognitive Impairment, Cognitive Decline, Alzheimer Disease
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
All
Ages:
75 years and above
Trial Updated:
01/17/2024
Locations: Northwestern University, Chicago, Illinois +6 locations
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
Recruiting
There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia. MCI impacts 12-18% of people in the United States over age 60 years (Alzheimer's Association. Mild Cognitive Impairment (MCI) available at https://www.alz.org/alzheimers-dementia/what-is-dementia/related_conditions/mild-cognitive-impairment. Accessed August 16, 2022). MCI does not substantially interfere with daily activities, although complex... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
12/13/2023
Locations: Advocate Memory Center, Park Ridge, Illinois
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognitive Decline, Cognitive Impairment, Memory Impairment
Speech Accessibility Project
Recruiting
The goal of the Speech Accessibility Project at the University of Illinois Beckman Institute (https://speechaccessibilityproject.beckman.illinois.edu) is to collect, annotate, and curate a shared database of speech samples from people with atypical speech, and share this data set with researchers at other organizations. This two-year project plans to collect 1,200,000 speech samples from 2,000 people, each of whom will provide 600 samples. In Year 1, the initial focus will be people with Parkins... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: University of Illinois at Urbana-Champaign, Urbana, Illinois
Conditions: Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Dementia With Lewy Bodies
ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings
Recruiting
Our study objective is to widely implement and evaluate a user-centered, scalable, electronic health record (EHR)-linked strategy for the routine detection of cognitive decline among diverse primary care settings. This strategy, called ToolboxDetect, will provide an efficient and sensitive cognitive screen that can be easily implemented in everyday clinical settings, and is responsive to patient, family, and caregiver concerns for potential symptoms of cognitive decline (CD) and cognitive impair... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
11/14/2023
Locations: Northwestern University, Chicago, Illinois
Conditions: Cognitive Dysfunction, Dementia
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Recruiting
The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and one-fourth will receive Placebo during the 24-week treatment duration.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/16/2023
Locations: Northwestern University, Chicago, Illinois
Conditions: Semantic Dementia
Trial of Parkinson's And Zoledronic Acid
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Northwestern Medicine, Chicago, Illinois +4 locations
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/03/2021
Locations: The University of Chicago Medical Center, Chicago, Illinois
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment