The state of Maryland currently has 17 active clinical trials seeking participants for Alzheimer's Disease research studies. These trials are conducted in various cities, including Baltimore, Bethesda, Rockville and Annapolis.
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Recruiting
This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve quality of life in those individuals.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/14/2024
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Recruiting
CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease. This single-site (Baltimore, Maryland) phase II clinical trial is a 2-week, randomized, placebo-controlled crossover study of the effects of the selective glucocorticoid receptor antagonist, CORT108297, on cognitive test performance in 26 individuals with mild cognitive impairment (MCI) due to AD and in 26 cognitively normal... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/17/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Memory Impairment
ALIGN: Aligning Medications With What Matters Most (Demonstration)
Recruiting
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/10/2024
Locations: Johns Hopkins Community Physicians, Baltimore, Maryland
Conditions: Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
Music Therapy for Patients With Alzheimer's Disease
Recruiting
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study p... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
04/09/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Mild Cognitive Impairment, Alzheimer Disease
Medicare Anti-Aβ mAb Coverage With Evidence Development (CED) Study
Recruiting
The Anti-Aβ mAb CED Study is a prospective, longitudinal coverage with evidence development (CED) study using clinical data, patient assessments, and administrative claims data of the Medicare population, conducted in accordance to the National Coverage Determination (NCD) on Monoclonal Antibodies Directed Against Amyloid for the Treatment of Alzheimer's Disease (AD).
Gender:
All
Ages:
All
Trial Updated:
09/21/2023
Locations: Centers for Medicare and Medicaid Services, Baltimore, Maryland
Conditions: Mild Alzheimer's Disease, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease