The state of Maryland currently has 16 active clinical trials seeking participants for Dementia research studies. These trials are conducted in various cities, including Baltimore, Bethesda, Rockville and Annapolis.
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
Recruiting
The primary objective of this study is to enroll an observational cohort of approximately 60 patients with PSP over the course of 24 months using a multicenter study design and to follow each of them for 12 months. The secondary objective of this study is to develop a robust solution for multi-modal remote monitoring of motor symptoms and function in PSP that can be applied to other Frontotemporal lobar degeneration (FTLD) syndromes.
Gender:
ALL
Ages:
Between 40 years and 89 years
Trial Updated:
11/18/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: PSP, CBD, Progressive Supranuclear Palsy, FTD, Corticobasal Degeneration, Frontotemporal Dementia, Frontotemporal Lobar Degeneration
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
All
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
ALIGN: Aligning Medications With What Matters Most (Demonstration)
Recruiting
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/10/2024
Locations: Johns Hopkins Community Physicians, Baltimore, Maryland
Conditions: Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
Cognitive and Vascular Functioning Following TBI
Recruiting
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data
Gender:
All
Ages:
Between 18 years and 74 years
Trial Updated:
12/06/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Traumatic Brain Injury, Cognitive Decline, Vascular Dementia