The state of Massachusetts currently has 23 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy
NCT04526418
Recruiting
The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording. The present study is a 12-week open-label, prospective study with a paired, comparative design for pivotal evaluation of the safety and effectiveness of the 24/7 EEGTM SubQ system in subjects with temporal lobe epilepsy. 2-5 sites in Europe Up to 5 sites in US, or up to 10 sites if... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/20/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Optimal Stimulation Parameters to Disrupt Epileptiform Activity
NCT06141668
Recruiting
Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.
Gender:
All
Ages:
All
Trial Updated:
11/15/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Refractory Epilepsy
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Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial
NCT03868293
Recruiting
The aim of the proposed pilot study is to investigate patient tolerability and efficacy of moderate term, repeated exposure of Pulsed Low-Intensity Focused Ultrasound (PLIFUS) in patients with drug-resistant temporal lobe epilepsy.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: Brigham and women's Hospital, Boston, Massachusetts
Conditions: Drug Resistant Epilepsy
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Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services
NCT06082999
Recruiting
Overall, this observational cohort study aims too: Implement rapid trio WGS for all children presenting to our health systems with epilepsy onset under 12 months of age. Utilize electronic healthcare records and research databases to unite phenotypic and genomic data and to create a "virtual" registry across all institutions that will promote ongoing discovery. Assess the impact of early genetic diagnosis on epilepsy, developmental, and health economic outcomes through formal longitudinal asses... Read More
Gender:
All
Ages:
12 months and below
Trial Updated:
10/11/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Human Epilepsy Genetics--Neuronal Migration Disorders Study
NCT00041600
Recruiting
The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.
Gender:
All
Ages:
All
Trial Updated:
09/20/2023
Locations: Boston Children's Hospital, Walsh Laboratory, Boston, Massachusetts
Conditions: Epilepsy, Brain Malformation, Neuronal Migration Disorder, Cognition Disorder
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
All
Ages:
Between 1 day and 6 months
Trial Updated:
08/21/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Tuberous Sclerosis Complex, Epilepsy
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Neonatal Seizure Registry - Developmental Functional EValuation
NCT04337697
Recruiting
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.
Gender:
All
Ages:
Between 2 years and 8 years
Trial Updated:
08/08/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages, Epilepsy, Cerebral Palsy, Intellectual Disability
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Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
NCT04770337
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
All
Ages:
9 years and above
Trial Updated:
07/21/2023
Locations: Boston Children's Hospital Comprehensive Epilepsy Center, Boston, Massachusetts +1 locations
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
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Sleep Spindles and Memory in Rolandic Epilepsy
NCT04569708
Recruiting
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Gender:
All
Ages:
Between 4 years and 18 years
Trial Updated:
06/01/2023
Locations: Athinoula A. Martinos Center Biomedical Imaging, Charlestown, Massachusetts
Conditions: Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy
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Neural Circuits for Action Perception
NCT05507320
Recruiting
Study the mechanisms underlying action recognition and execution
Gender:
All
Ages:
Between 14 years and 70 years
Trial Updated:
08/17/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy
NCT03857074
Recruiting
The purpose of this study is to obtain preliminary data in advance of a larger clinical trial aimed to test whether a single session of green light exposure can lead to a clinically significant reduction in epileptic spikes in patients with medically-refractory epilepsy. As this is a potentially fragile patient population, the study will test safety and tolerability as well as efficacy.
Gender:
All
Ages:
Between 6 months and 30 years
Trial Updated:
03/08/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy, Epilepsy Intractable
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