The state of Michigan currently has 17 active clinical trials seeking participants for Multiple Sclerosis research studies. These trials are conducted in various cities, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo.
A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
NCT05090371
Recruiting
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
01/21/2025
Locations: Henry Ford Hospital, Detroit, Michigan +1 locations
Conditions: Relapsing-Remitting Multiple Sclerosis
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A Pilot Randomized Controlled Trial: CoINTEGRATE
NCT05732285
Recruiting
The purpose of this study is to examine the feasibility of comprehensive multimodal individually tailored Cognitive Behavioral Therapy (CBT), Cognitive Rehabilitation Therapy (CRT), and modifiable lifestyle sessions. The study team hypothesizes that combining evidence-based cognitive and affective therapies with lifestyle modifications is feasible and will improve the community integration (CI) and Quality of life (QoL) in patients with a neurocognitive disorder compared to usual care.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
08/26/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Neurocognitive Disorders, Cognitive Dysfunction, Traumatic Brain Injury, Multiple Sclerosis, Mild Cognitive Impairment
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ETNA-MS Device Validation Study
NCT06256731
Recruiting
The overarching goal of this research protocol is to validate the effectiveness of Innodem's ETNA-MS device in informing clinicians on the disability status of Multiple Sclerosis (MS) patients. Effectiveness of the device will be assessed by the level of agreement between the EDSS estimated by the device and the actual scores measured by the neurologist in-person assessments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Michigan Institute for Neurological Disorders, Farmington Hills, Michigan +1 locations
Conditions: Multiple Sclerosis
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TRAIN-BW: Backward Walking Training in Multiple Sclerosis
NCT04091464
Recruiting
Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/11/2023
Locations: Wayne State University, Detroit, Michigan
Conditions: Multiple Sclerosis, Gait Disorders, Neurologic, Accidental Fall
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Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis
NCT04458688
Recruiting
The investigators intend to examine the effects of ocrelizumab use in African American multiple sclerosis disease course compared to Caucasian disease course utilizing imaging measures with magnetic resonance imaging (MRI) and optical coherence tomography angiography (OCT-A)..
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/03/2022
Locations: Wayne State University, Detroit, Michigan
Conditions: Multiple Sclerosis, Relapsing-Remitting
Register for Updates