The state of Minnesota currently has 16 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Minneapolis, Rochester, Saint Paul and Duluth.
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
NCT04770337
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
ALL
Ages:
9 years and above
Trial Updated:
11/14/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
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Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
NCT05493722
Recruiting
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Refractory Epilepsy, Deep Brain Stimulation
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Optimizing Brain Stimulation Parameters
NCT06617845
Recruiting
A primary purpose of this study is to better understand what stimulation parameters work best for patients. For example, for Deep Brain Stimulation (DBS) of the Anterior Nucleus of the Thalamus (ANT), it is not clear what stimulation frequency leads is most effective. This study will help assess the effectiveness of low frequency or high frequency stimulation.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
09/27/2024
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Epilepsy; Seizure
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/13/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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