The state of North Carolina currently has 44 active clinical trials seeking participants for Arthritis research studies. These trials are conducted in various cities, including Durham, Charlotte, Winston-Salem and Chapel Hill.
Preventing Injured Knees From osteoArthritis: Severity Outcomes
Recruiting
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administrati... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
05/07/2024
Locations: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
Recruiting
The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). The main objectives are to compare the effects of Standard rehabilitation vs. rehabilitation that includes whole body vibration (WBV) or local muscle vibration (LMV) on: Quadriceps muscle function Gai... Read More
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
04/29/2024
Locations: MOTION Science Institute, Chapel Hill, North Carolina +1 locations
Conditions: Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
Study to Evaluate Pregnancy Outcomes in Risankizumab Exposed Pregnancies Relative to Those Non-risankizumab Exposed Pregnancies in Women With FDA Approved Indications
Recruiting
The objective of this registry is to compare outcomes of risankizumab-exposed pregnancies with those of pregnancies that were not exposed to risankizumab among women with plaque psoriasis, psoriatic arthritis (PsA), Crohn's disease (CD), or other conditions for which risankizumab is an FDA-approved treatment. The registry is designed to estimate the association between risankizumab and maternal, fetal, and infant outcomes by comparing the prevalence rates of these outcomes in the exposed and une... Read More
Gender:
Female
Ages:
All
Trial Updated:
03/05/2024
Locations: Evidera, a PPD Business Unit /ID# 238688, Morrisville, North Carolina +1 locations
Conditions: Plaque Psoriasis, Psoriatic Arthritis, Crohn Disease, Other Conditions for Which Risankizumab is an FDA-approved Treatment
Exactech Shoulder Post Market Clinical Follow-up Study
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
All
Ages:
21 years and above
Trial Updated:
02/23/2024
Locations: Southeastern Sports Medicine and Orthopedics, Asheville, North Carolina
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
Recruiting
The objectives of this study are to evaluate the performance and safety of the Vantage Total Ankle System. This study will follow subjects for a period of up to 10 years post-surgery.
Gender:
All
Ages:
21 years and above
Trial Updated:
02/23/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: West Clinical Research, Morehead City, North Carolina
Conditions: Knee Osteoarthritis
Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
Recruiting
The overall goal of this pilot randomized trial is to obtain necessary prerequisite data to conduct a randomized controlled intervention to test the effect of vitamin K supplementation on knee osteoarthritis progression and related functional decline. To address critical parameters required to design this larger RCT, we will conduct a double-blind, 2-armed, parallel-group intervention study, with a placebo run-in, in which 50 adults with mild to moderate knee OA and low baseline vitamin K status... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
11/27/2023
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: Osteo Arthritis Knee
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
Recruiting
This study is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function associated with osteoarthritis of the knee joint.
Gender:
All
Ages:
Between 35 years and 85 years
Trial Updated:
09/07/2023
Locations: OrthoCarolina Research Institute, Charlotte, North Carolina +1 locations
Conditions: Osteoarthritis, Knee