The state of North Carolina currently has 37 active clinical trials seeking participants for Asthma research studies. These trials are conducted in various cities, including Durham, Winston-Salem, Charlotte and Chapel Hill.
A 12-week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS)
Recruiting
This is a 12-week study to evaluate the efficacy and safety of budesonide and formoterol fumarate metered dose inhaler relative to budesonide metered dose inhaler in adults and adolescents with inadequately controlled asthma.
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
03/06/2024
Locations: Research Site, Charlotte, North Carolina +4 locations
Conditions: Asthma
A 24-Week Efficacy and Safety Study to Assess Budesonide and Formoterol Fumarate Metered Dose Inhaler in Adult and Adolescent Participants With Inadequately Controlled Asthma (VATHOS)
Recruiting
This is a 24 week study to evaluate the efficacy and safety of budesonide and formoterol fumarate metered dose inhaler in adults and adolescents with inadequately controlled asthma.
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
03/05/2024
Locations: Research Site, Charlotte, North Carolina +5 locations
Conditions: Asthma
Phase I Assessment of Hypertonic Saline in Moderate to Severe Asthmatics
Recruiting
Purpose: To determine if inhaled hypertonic saline (HS) accelerates airway mucociliary clearance (MCC) in well-controlled moderate to severe asthmatics.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/29/2024
Locations: Center for Environmental Medicine, Asthma and Lung Biology, Chapel Hill, North Carolina
Conditions: Moderate to Severe Asthma
NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)
Recruiting
Background: - Asthma is a serious clinical and public health problem. Researchers want to collect data to better understand how bacteria and other things in the environment can affect people's asthma. Eligibility: - Nonsmoking adults age 18 - 60 who have moderate to severe asthma. Design: Participants will complete a medical history form before the first visit. Study visits will include collecting medical history, and conducting physical exam, lung and smoking tests. Participants will give... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/22/2024
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Asthma
Treating Respiratory Emergencies in Children Study
Recruiting
Over 200,000 children have a 911 Emergency Medical Services (EMS) activation for respiratory distress each year, most of whom have acute wheezing. Early treatment in the prehospital setting could more rapidly relieve respiratory distress symptoms, prevent hypoxia, reduce invasive interventions, and reduce the need to be hospitalized, thereby facilitating earlier return to normal daily activities. Preliminary data from one site found hospital admission was reduced from 30% to 21% among children w... Read More
Gender:
All
Ages:
Between 2 years and 17 years
Trial Updated:
02/22/2024
Locations: Mecklenburg County EMS, Charlotte, North Carolina
Conditions: Asthma in Children
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
Recruiting
The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without additional controller medication. Patients who complete treatment will enter 4 weeks follow-up period.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
02/14/2024
Locations: Research Site, Durham, North Carolina +2 locations
Conditions: Asthma
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS)
Recruiting
This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
02/13/2024
Locations: Research Site, Charlotte, North Carolina +6 locations
Conditions: Asthma
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Eosinophilic Asthma
Recruiting
The purpose of this study is to evaluate dexpramipexole as an add-on oral therapy in participants with inadequately controlled eosinophilic asthma to evaluate improvements in lung function, asthma control, and quality of life. In addition, the study will further evaluate the safety and tolerability of dexpramipexole in participants with eosinophilic asthma.
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
02/09/2024
Locations: Research Site 40001-039, Gastonia, North Carolina
Conditions: Eosinophilic Asthma, Asthma; Eosinophilic, Asthma Attack
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
Recruiting
This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations.
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
02/09/2024
Locations: Research Site 20001-039, Gastonia, North Carolina
Conditions: Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)
Recruiting
This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
02/01/2024
Locations: Research Site, Charlotte, North Carolina +5 locations
Conditions: Asthma
Terbutaline Sulfate in Adults With Asthma
Recruiting
The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2. The overall aim in Part 2 is to evaluate the optimal IV dosing of terbutaline sulfate based on PD response and safety data.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
01/02/2024
Locations: Duke Early Phase Research Unit (DEPRU), Durham, North Carolina
Conditions: Asthma
Oxidative Stress in Asthma
Recruiting
40% of all asthma patients in the US are obese. Obese asthmatics have more severe disease than lean asthmatics and do not respond as well to conventional anti-inflammatory therapies. This proposal will utilize 3D functional imaging with 129XeMRI and single cell RNA sequencing to study mechanisms driving regional airway remodeling and fibrosis in obese asthma subjects and in preclinical models of obese asthma.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/18/2023
Locations: Duke Asthma Allergy and Airway Center, Durham, North Carolina
Conditions: Asthma, Obesity